Results 61 to 70 of about 5,255,382 (240)

Fatal subarachnoid hemorrhage after ventriculoperitoneal shunt placement to manage communicating hydrocephalus due to melanoma leptomeningeal disease

, 2023
Leptomeningeal disease (LMD) is a rare, late complication of malignant cancers. In addition to causing significant neurosurgical morbidity, LMD can cause communicating hydrocephalus by disrupting the cerebrospinal fluid (CSF) outflow.
Adam Alayli, Jonah Gordon, Nam D. Tran, Gavin Lockard   +3 more
core   +1 more source

Leptomeningeal metastases in solid tumors [PDF]

, 2014
Background: Leptomeningeal metastases are diagnosed in 1% to 8% of patients with cancer. The most common histology is leukaemia, lymphoma, breast carcinoma, lung carcinoma and melanoma.
Dimitrovska Ivanova, Marija, Karakolevska Ilova, Marija, Simeonovska Joveva, Elena   +2 more
core   +2 more sources

Case report: Concurrent intrathecal and intravenous pembrolizumab for metastatic melanoma with leptomeningeal disease

Frontiers in Oncology
Leptomeningeal disease (LMD) is a serious cancer complication associated with poor prognosis. Approximately 5%–25% of patients with melanoma develop LMD. Currently, no standard treatment protocol exists and very few cases have been reported.
Xiang Dan, Mengxi Huang, Zhaochen Sun, Zhaochen Sun, Xiaoyuan Chu, Xin Shi, Yitian Chen   +6 more
doaj   +1 more source

Implications of Intrathecal Chemotherapy for Anaesthesiologists: A Brief Review

Scientifica, 2016
Intrathecal chemotherapy is routinely prescribed in medical oncology practice, either for prophylaxis or for treatment of leptomeningeal disease due to a primary haematological disease or a metastatic disease due to any other malignancy.
Abhijit Nair
doaj   +1 more source

Centrum Semiovale Perivascular Spaces Predict First Hemorrhagic Lesion in Asymptomatic Amyloid‐Positive Individuals

Annals of Neurology, EarlyView.
Objective Identification of cerebral amyloid angiopathy (CAA) before its hemorrhagic manifestations remains limited. We aimed to determine whether severe enlarged perivascular spaces in the centrum semiovale (EPVS‐CSO) identify a prehemorrhagic stage of sporadic CAA by predicting the first appearance of CAA‐related hemorrhagic lesions or incident ...
Baris Alten, Elif Gokcal, Reisa A. Sperling, Zahra Shirzadi, Jasmeer P. Chhatwal, M. Edip Gurol, Scott E. Kasner, Steven M. Greenberg, Brett L. Cucchiara   +8 more
wiley   +1 more source

Observing Huntington's disease: the European Huntington's Disease Network's REGISTRY. [PDF]

, 2010
The unparalleled collection of clinical data and biomaterials within the EHDN's REGISTRY can expedite the search for disease modifiers (genetic and environmental) of age at onset and disease progression that could be harnessed for the development of ...
Handley, Olivia J, Landwehrmeyer, G Bernhard, Aileen K Ho, Bisson, Jonathan Ian, Schwenke C, David Craufurd, Dunnett, Stephen B., Handley, Olivia, Investigators of the European Huntington's Disease Network, The, DI MARIA, EMILIO, Craufurd D, Dunnett, SB, Carsten Schwenke, the investigators of the European Huntington's Disease Network, Craufurd, David, Edward Wild, Landwehrmeyer, GB, Busse, Monica, Rosser, Anne Elizabeth, Olivia J Handley, Romano Silvia., Tabrizi SJ, Ho, Aileen K., Wild, E, Landwehrmeyer GB, Craufurd, D, Tabrizi, SJ, Tabrizi, Sarah J., Handley, OJ, Rickards, Hugh, Dunnett, Stephen, Ho, Aileen K, Orth, Michael, Ho, AK, Wild, Edward, Stephen B. Dunnett, Sarah J Tabrizi, Wild, EJ, Landwehrmeyer, G. Bernhard, Naji, Jenny, Landwehrmeyer, G. Bernhard, Wild E, Investigators of the European Huntington's Disease Network, Handley, Olivia J., Orth, M, Ellison-Rose, Lynda, Tabrizi, Sarah J, Price, Kathleen, Ho AK, ABBRUZZESE, GIOVANNI, Schwenke, C, Ho, A, Orth M, Handley OJ, Schwenke, Carsten, Dunnett SB, Dunnett, Stephen B, Michael Orth, G. Bernhard Landwehrmeyer   +59 more
core   +1 more source

Radiotherapy in Leptomeningeal Disease: A Systematic Review of Randomized and Non-randomized Trials

Frontiers in Oncology, 2019
Background: Leptomeningeal disease (LMD), also known as neoplastic meningitis, leptomeningeal carcinomatosis, or carcinomatous meningitis, is a rare cancer complication occurring in ~5% of cases and ultimately leads to significant morbidity and mortality.
Samantha M. Buszek, Caroline Chung
doaj   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Intra-operative cerebrospinal fluid sampling versus post-operative lumbar puncture for detection of leptomeningeal disease in malignant paediatric brain tumours - Fig 1

, 2018
(A) Post-contrast T1-weighted MRI cervico-thoracic spine demonstrating extensive leptomeningeal enhancement along vertical axis of spinal dura. Red and yellow arrows depict leptomeningeal disease consistent with metastasis. (B) Yellow arrow correlates to
Kenneth T. E. Chang (625645), Chan Yiong Huak (5172299), Sharon Y. Y. Low (5172290), Seow Wan Tew (5172293), David C. Y. Low (5172302), Chen Min Wei (5172287), Ng Lee Ping (5172296)   +6 more
core   +1 more source

Leptomeningeal carcinomatosis in sinonasal NUT carcinoma: a case report and review of intracranial involvement

Frontiers in Oncology
BackgroundSinonasal NUT carcinoma is a rare and highly aggressive malignancy, frequently diagnosed at advanced stages with poor prognosis. Intracranial spread is uncommon and, to our knowledge, leptomeningeal carcinomatosis has not been previously ...
Francisco Manuel Rodríguez-Santiago, Francisco Manuel Rodríguez-Santiago, Francisco Manuel Rodríguez-Santiago, Silvia Sequero López, Silvia Sequero López, Antonio Jesús Láinez-Ramos-Bossini, Antonio Jesús Láinez-Ramos-Bossini, Antonio Jesús Láinez-Ramos-Bossini   +7 more
doaj   +1 more source