Results 81 to 90 of about 5,255,382 (240)

Intrathecal trastuzumab in the management of HER2+ breast leptomeningeal disease: a single institution experience

, 2018
PURPOSE: Leptomeningeal disease is a rare and devastating presentation of advanced stage metastatic breast cancer with historically poor overall survival.
Nicholas B. Figura, Wendy Long, Roberto Diaz, Figura, Nicholas B, Diaz, Roberto, Nam D. Tran, Kamran A. Ahmed, Robinson, Timothy J, Sahebjam, Solmaz, Yu, Michael, Sepideh Mokhtari, Ahmed, Kamran A, Peter A. Forsyth, Etame, Arnold B, Long, Wendy, Solmaz Sahebjam, Han, Heather S, Heather S. Han, Mokhtari, Sepideh, Tran, Nam D, Forsyth, Peter A, Timothy J. Robinson, Soliman, Hatem, Hatem Soliman, Arnold B. Etame, Michael Yu   +25 more
core   +1 more source

Triphasic waves in leptomeningeal metastases and cycling alternating pattern of encephalopathy during sleep

Epileptic Disorders, EarlyView.
Abstract Background Triphasic waves (TWs), now termed generalized periodic discharges with triphasic morphology, may be mistaken for nonconvulsive status epilepticus (NCSE), particularly in critically ill patients. Changes in vigilance over time can help distinguish encephalopathic patterns from ictal activity.
Philippe Gélisse, Arielle Crespel
wiley   +1 more source

A pilot study of bevacizumab combined with etoposide and cisplatin in breast cancer patients with leptomeningeal carcinomatosis

, 2017
Background: Elevated vascular endothelial growth factor (VEGF) was associated with poor prognosis in leptomeningeal carcinomatosis and anti-angiogenic therapy was found to prolong the survival of mice in preclinical studies.
Wu, Pei-Fang;Lin, Ching-Hung;Kuo, Ching-Hua;Chen, Wei-Wu;Yeh, Dah-Cherng;Liao, Hsiao-Wei;Huang, Shu-Min;Cheng, Ann-Lii;Lu, Yen-Shen, 陳偉武;盧彥伸;林璟宏;郭錦樺;吳佩芳;鄭安理;林季宏   +1 more
core   +1 more source

PRIMARY DIFFUSE LEPTOMENINGEAL GLIOMATOSIS IN TWO DOGS.

, 2013
Clinical, neuroimaging and neuropathological findings of two cases of canine primary diffuse leptomeningeal gliomatosis are described. Magnetic resonance imaging and histopathological examination of the brain revealed diffuse leptomeningeal alterations ...
PAVONE, SILVIA, MANDARA, Maria Teresa, M. Bernardini, S. Canal   +3 more
core   +1 more source

Craniofacial Resection for Advanced Cutaneous Squamous Cell Carcinoma: Results From the 2nd International Collaborative Case‐Series

Head &Neck, EarlyView.
ABSTRACT Background Robust outcome data for anterior skull base cutaneous squamous cell carcinoma (cSCC) are limited, particularly as emerging therapies reshape management. We evaluated survival and prognostic factors following craniofacial resection. Methods Retrospective multi‐institutional case‐series (1995–2015) of patients who underwent skull base
Michael J. C. Schachtel, Benedict J. Panizza, James J. Bowman, Catherine Barnett, Cristina Valero, Ian Ganly, Snehal G. Patel, Helena Levyn, Dauren Adilbay, Alana Eagan, Marc A. Cohen, Lillian A. Boe, Junting Zheng, Mithat Gonen, Prathamesh Pai, Paolo Castelnuovo, Fang Ju Gao, Cesare Piazza, Piero Nicolai, Luiz P. Kowalski, Ronaldo N. Toledo, Claudio Cernea, Sergio Goncalves, Dan M. Fliss, John R. de Almeida, Ian Witterick, Philippe Herman, Walter Fontanella, Gregorio Sanchez Aniceto, Alvaro Rivero Calle, Sefik Hosal, Serdar Ozer, Subramania Iyer, Richard J. Harvey, C. Rene Leemans, Jan‐Jaap Hendrickx, Marcelo Figari, Luis Boccalatte, Ken Ichi Nibu, Peter Clarke, Catherine Rennie, Yiming Zhu, Rodney J. Schlosser, Fernando L. Dias, Zoukaa Sargi, Shahzada Ahmed, Wojciech Golusinski, Se Heon Kim, Shirley Y. Su, Shaan M. Raza, Franco DeMonte, Ehab Hanna, Jatin P. Shah   +52 more
wiley   +1 more source

Experimental Treatments for Leptomeningeal Metastases from Solid Malignancies

, 2017
Background: Leptomeningeal metastasis is a consequence of advanced solid malignancies and has limited treatment options. It is possible that it is becoming more common as the leptomeninges act as a sanctuary site for recurrence from systemic cancer ...
Keiran S. Smalley, Smalley, Keiran S., Tran, Nam D., Nam D. Tran, Solmaz Sahebjam, Sahebjam, Solmaz, Forsyth, Peter A., Peter A. Forsyth   +7 more
core   +1 more source

Neoplastic leptomeningitis presenting in a melanoma patient treated with dabrafenib (a ^V600EBRAF inhibitor): a case report

Journal of Medical Case Reports, 2012
Introduction Leptomeningeal metastases are occurring at higher frequency in cancer patients. The prognosis of leptomeningeal metastases is poor and standard treatment, which includes radiotherapy and chemotherapy, is mostly ineffective.
Simeone Ester, De Maio Eleonora, Sandomenico Fabio, Fulciniti Franco, Lastoria Secondo, Aprea Pasquale, Staibano Stefania, Montesarchio Vincenzo, Palmieri Giuseppe, Mozzillo Nicola, Ascierto Paolo A   +10 more
doaj   +1 more source

Leptomeningeal Disease: Current Approaches and Future Directions. [PDF]

Curr Neurol Neurosci Rep
Abstract Purpose of Review Leptomeningeal disease (LMD), or spread of cancer cells into the pia and arachnoid membranes encasing the brain and spinal cord, is associated with high symptom burden and poor survival at 2 to 5 months. Conventional treatments including photon-based radiation therapy, systemic chemotherapy,
Sener U, Wilcox JA, Boire AA.
europepmc   +3 more sources

Long‐Term Clinical Response After Low‐Dose and Short‐Duration Cemiplimab Therapy in a Patient With Xeroderma Pigmentosum in Nepal

JEADV Clinical Practice, EarlyView.
Capsule Summary Xeroderma pigmentosum (XP) is associated with a high risk of multiple and aggressive cutaneous squamous cell carcinomas (CSCCs). The immune checkpoint inhibitor cemiplimab has been approved in advanced, unresectable, and/or metastatic CSCCs.
Sudip Parajuli, Arnab Panta, Sabina Bhandari, Anne Grange, Florent Grange, Upama Paudel   +5 more
wiley   +1 more source

Mass Spectrometry Imaging–Guided Proteomics, an Emerging Frontier in Spatial Biology

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Spatial heterogeneity is a defining feature of tissue organization, yet conventional proteomic analysis provides limited information about the spatial origins of identified proteins. Spatially guided proteomics addresses this limitation by using tissue imaging techniques to select regions of interest (ROIs) for localized analysis by liquid ...
Kenneth Weke, Julian J. Lum, David R. Goodlett, Helena Pětrošová, Irena Dapic   +4 more
wiley   +1 more source