Results 101 to 110 of about 5,255,382 (240)

A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases [PDF]

, 2018
While the preponderance of morbidity and mortality in medulloblastoma patients are due to metastatic disease, most research focuses on the primary tumor due to a dearth of metastatic tissue samples and model systems.
Garancher, Alexandra, Cybulsky, Myron, Hawkins, Cynthia E, Bouffet, Eric, Kenneth Aldape, Cho, Yoon Jae, Thompson, Yuan Yao, Steven J.M. Jones, De Antonellis, Pasqualino, Fults, Daniel W., Farooq, Hamza, Richard Moore, Shih, David JH, Sumerauer, David, Angela Li, David Sumerauer, Jennifer A. Chan, Michal Zapotocky, Mitra, Siddhartha, Li, Angela, Liu, Jessica, Massimino, Maura, A. Sorana Morrissy, Woodgett, James R, Taylor, Michael D., Peter Dirks, Jones, Steven JM, Brastianos, Priscilla K., Kuzan-Fischer, Claudia, Cho, Yoon-Jae, Eric Bouffet, Tabori, Uri, Weiss, William A., Claudia Kuzan-Fischer, Clinton S. Robbins, Livia Garzia, Sherine Ensan, Poul H.B. Sorensen, Yoon-Jae Cho, Peacock, John, Nada Jabado, Alex Manno, Wechsler-Reya, Robert J., Qin, Lei, Skowron, Patryk, James R. Woodgett, Michael Parsons, Nor, Carolina, Hawkins, Cynthia E., Wechsler-Reya, Robert J, John Peacock, Michael D. Taylor, Robbins, Clinton S, Holgado, Borja L., Manno, Alex, Uri Tabori, Sorensen, Poul H.B., Fults, Daniel W, Chan, Jennifer A, Wang, Xin, Alexandra Garancher, Noriyuki Kijima, Donovan, Laura K, Aldape, Kenneth, Lei Qin, Marco A. Marra, Xin Wang, Marra, Marco A., Cynthia E. Hawkins, Siddhartha Mitra, Kun-Wei Liu, Ramaswamy, Vijay, Mansouri, Sheila, Holgado, Borja L, David J.H. Shih, Guerreiro-Stucklin, Ana, Patryk Skowron, Maura Massimino, Kijima, Noriyuki, Luu, Betty, Parsons, Michael, Garzia, Livia, Zapotocky, Michal, Brastianos, Priscilla K, Kory Zayne, Yussanne Ma, Andy Mungall, Carolina Nor, Sheila Mansouri, William A. Weiss, Jessica Liu, Yuan Yao Thompson, Hamza Farooq, Jones, Steven J.M., Priscilla K. Brastianos, Marra, Marco A, Morrissy, A. Sorana, Ensan, Sherine, Moore, Richard, Donovan, Laura K., Chan, Jennifer A., Pasqualino De Antonellis, Sorensen, Poul HB, Robbins, Clinton S., Morrissy, A Sorana, Borja L. Holgado, Daniel W. Fults, Liu, Kun-Wei, Ana Guerreiro-Stucklin, Mungall, Andy, Weiss, William A, Shih, David J.H., Zayne, Kory, Ma, Yussanne, Vijay Ramaswamy, Liu, Kun Wei, Wu, Xiaochong, Dirks, Peter, Woodgett, James R., Jabado, Nada, Xiaochong Wu, Betty Luu, Taylor, Michael D, Laura K. Donovan, Myron Cybulsky, Robert J. Wechsler-Reya   +125 more
core   +1 more source

Isolated central nervous system relapse in acute myeloid leukemia: a case report and review of therapeutic challenges

Frontiers in Oncology
Central nervous system (CNS) relapse in acute myeloid leukemia (AML) is an uncommon but clinically significant event, with isolated CNS involvement occurring in a minority of cases and often eluding standard surveillance protocols.
Colin Burns, Ian Muir, Jennifer Foster, Anthony Emanuel, Mark Kochenderfer   +4 more
doaj   +1 more source

Circumscribed Meningeal Melanocytic Neoplasms: CNS WHO Grade, Molecular Profile, and Clinical Outcomes

Brain Pathology, EarlyView.
In this study including 31 circumscribed meningeal melanocytic neoplasms (melanocytoma, intermediate‐grade melanocytic tumor [IMT], and melanoma), overall survival (OS) differed significantly among the groups, with melanoma showing significantly worse OS than melanocytoma and IMT showing intermediate OS between melanocytoma and melanoma.
Yi Zhu, Nishika Karbhari, Timothy J. Kaufmann, Aditya Raghunathan, Cristiane M. Ida, Cinthya J. Zepeda‐Mendoza, Ian J. Dryden, Shahriar Salamat, Chathu Atherton, Sarah M. Jenkins, Svetomir N. Markovic, Ugur T. Sener, Caterina Giannini   +12 more
wiley   +1 more source

Lung Cancer Brain Metastasis: Brain Microenvironmental Adaptation, Therapeutic Resistance and Translational Strategies

Cancer Science, EarlyView.
Lung cancer brain metastasis is shaped by dynamic crosstalk among tumor cells, the blood–brain barrier, glial and immune cells, neurons, and metabolic niches. This review integrates these mechanisms with therapeutic resistance, translational models, CNS delivery, and multidisciplinary treatment strategies.
Jun Yang, Junyi Xiong, Li Ying, Yanyang Zeng, Ziqiang Ouyang, Mei Liu, Meihua Li   +6 more
wiley   +1 more source

Targeted Therapy After Brain Radiotherapy for BRAF-Mutated Melanoma With Extensive Ependymal Disease With Prolonged Survival: Case Report and Review of the Literature

Frontiers in Oncology, 2019
Melanoma brain metastasis with ependymal spread/metastases is uncommon. These cases are frequently classified together with leptomeningeal disease. However, the commonalities and differences in the underlying pathophysiology and clinical outcomes between
Ibrahim Abu-Gheida, Samuel Chao, Erin Murphy, John Suh, Glen H. Stevens, Alireza M. Mohammadi, Michael McNamara, Jennifer S. Yu, Jennifer S. Yu   +8 more
doaj   +1 more source

Proton Craniospinal Irradiation with Immunotherapy in Two Patients with Leptomeningeal Disease from Melanoma [PDF]

Journal of Immunotherapy and Precision Oncology
Introduction Proton craniospinal irradiation (pCSI) is a treatment option for leptomeningeal disease (LMD), which permits whole neuroaxis treatment while minimizing toxicity. Despite this, patients inevitably experience progression.
Ugur Sener, Mason Webb, William G. Breen, Bryan J. Neth, Nadia N. Laack, David Routman, Paul D. Brown, Anita Mahajan, Kelsey Frechette, Arkadiusz Z. Dudek, Svetomir N. Markovic, Matthew S. Block, Robert R. McWilliams, Anastasios Dimou, Lisa A. Kottschade, Heather N. Montane, Sani H. Kizilbash, Jian L. Campian   +17 more
doaj   +1 more source

Inborn errors of immunity in children with neuroinflammation

Developmental Medicine &Child Neurology, EarlyView.
Abstract Inborn errors of immunity (IEIs), an expanding group of monogenic disorders with diverse clinical manifestations, are increasingly recognized to include neuroinflammatory disease. Examples of diseases included under this umbrella are Aicardi–Goutières syndrome, deficiency of adenosine deaminase 2, familial haemophagocytic lymphohistiocytosis ...
Eppie M Yiu, Dilan Dissanayake, Jessie Cunningham, Helen Branson, Ori Scott, E Ann Yeh   +5 more
wiley   +1 more source

Amyloid and tau in the brain in sporadic Alzheimer’s disease: defining the chicken and the egg [PDF]

, 2014
In the October 2013 issue of Acta Neuropathologica there were three very interesting articles on: Amyloid or tau: the chicken or the egg? In the first article, David Mann and John Hardy argued that the deposition of aggregated amyloid β (Aβ) protein in ...
Cheryl A. Hawkes, Roy O. Weller, Roxana O. Carare, Hawkes, Cheryl A., Carare, Roxana O., Weller, Roy O.   +5 more
core   +1 more source

Beyond the Typical Atypical Imaging Features of Leptomeningeal Enhancement: A Case Series

Brain Sciences
Background and Purpose: Contrast-enhanced MRI findings of leptomeningeal enhancement (LME) indicate dysfunction of the blood–brain barrier and can be seen in various neoplastic, infectious, and inflammatory conditions.
Mohammad Hani, Mohammad Alkhaldi, Hafiz Talha Javed, Vansh Patel, Mohamad Assker, Rucha Bahekar, Parissa Feizi, Ashley E. Catseel, Teryn Lane, Shitiz Sriwastava   +9 more
doaj   +1 more source

Human cerebral arterial morphogenesis explored by 3D microscopic imaging of cleared embryos: Bridging the gap between embryonic and adult anatomy

Journal of Anatomy, EarlyView.
We provide a description of human embryonic cerebral arterial development based on whole‐mount immunostaining, tissue clearing, three‐dimensional (3D) light‐sheet microscopy imaging, and anatomically informed virtual segmentation of human embryos. Findings are compared with adult radiological anatomy. We provide a detailed account of the development of
Eimad Shotar, Raphaël Blain, Aymeric Nadjem, Nermine Saidi, Megumi Inoue, Daniel Smith‐Paredes, Miccaella Vergara, Armelle Lesaunier, Quentin Rappeneau, Joséphine Blevinal, Gérard Couly, Julien Burel, Julien Allard, Kevin Premat, Stéphanie Lenck, Pierre‐Marie Chiaroni, Erwah Kalsoum, Maryne Toupin, Séverine Mazaud‐Guittot, Diane Rebourcet, Paolo Giacobini, Olivier Naggara, Hugo Gortais, Grégoire Boulouis, Alexis Guédon, Philippe Gailloud, Frédéric Glicenstein, Anaïs Favre, Frédéric Clarençon, Yorick Gitton, Alain Chédotal   +30 more
wiley   +1 more source