Results 81 to 90 of about 1,232,023 (188)

PAK1 inhibitor NVS‐PAK1‐1 preserves dendritic spines in amyloid/tau exposed neurons and 5xFAD mice

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract INTRODUCTION Synaptic spine loss in Alzheimer's disease (AD) contributes to cognitive decline. p21‐activated kinase 1 (PAK1), a regulator of spine integrity, is aberrantly activated in AD. We investigated whether PAK1 inhibition might preserve dendritic spines in vitro and in vivo.
Tao Yang, Hasi Huhe, Sean‐Paul Williams, Sukhneet Kaur, Yeonglong Albert Ay, Zachary W. Davis‐Gilbert, Gregory A. Cary, Carolyn Paisie, Robert R. Butler III, Jesse Wiley, Ranjita Betarbet, Haian Fu, Duc Duong, Nicholas T. Seyfried, Karina Leal, Gregory W. Carter, Aled Edwards, Allan I. Levey, Jacob L. Capener, David H. Drewry, Mohammad A. Hossain, Hans J. Oh, Alison D. Axtman, Stacey J. Sukoff Rizzo, Frank M. Longo, The Emory‐Sage‐SGC‐Jax TREAT‐AD Center   +25 more
wiley   +1 more source

CRISPR/Cas9-mediated generation of human embryonic stem cell sub-lines with HPRT1 gene knockout to model Lesch Nyhan disease

, 2023
Lesch-Nyhan disease (LND) is a X-linked genetic disease affecting boys characterized by complex neurological and neuropsychiatric symptoms. LND is caused by loss of function mutations in the HPRT1 gene leading to decrease activity of hypoxanthine-guanine
Chatrousse, Laure, El-Kassar, Lina, Boissart, Claire, Claire Boissart, Thifaine Poullion, Poullion, Thifaine, Alexandra Benchoua, Laure Chatrousse, Karine Giraud-Triboult, Giraud-Triboult, Karine, Benchoua, Alexandra, Lina El-Kassar   +11 more
core   +1 more source

Lesch-Nyhan syndrome: A case report

Journal of Indian Society of Pedodontics and Preventive Dentistry, 2008
Lesch-Nyhan syndrome, a rare inborn error of metabolism, is characterized by mental retardation and self-destructive behavior resulting in self-mutilation through biting and scratching.
Kale A, Shah K, Hallikerimath S
doaj  

Bipolar affective disorder: A review of novel forms of therapy

Current Issues in Pharmacy and Medical Sciences, 2015
Normothymic, antidepressant and antipsychotic pharmaceutics are, in accordance with international guidelines, employed both in the therapy and the prevention of bipolar disorder (BD).
Dziwota Ewelina, Drapala Barbara, Gaj Magdalena, Skoczen Nikodem, Olajossy Marcin   +4 more
doaj   +1 more source

Lingual Dyskinesia as the Presenting Feature of Acquired Demyelinating Syndrome: A Case Report and Review of Differential Diagnoses

Journal of Paediatrics and Child Health, Volume 62, Issue 6, Page 1060-1065, June 2026.
Briana Davis, Ahmed Kaki, Eppie M. Yiu, Emma Macdonald‐Laurs   +3 more
wiley   +1 more source

Angelman syndrome: The blurred lines of interpretation in cognitive defects

Journal of Pediatric Neurosciences, 2015
Angelman syndrome is a neuro-developmental disorder with a genetic basis in maternal genomic imprinting that presents with cognitive and behavioral impairment.
Sushant Mane, Rudrarpan Chatterjee
doaj   +1 more source

Lesch-Nyhan syndrome: a case report. [PDF]

J Korean Assoc Oral Maxillofac Surg, 2023
Park HI, Kim GH, Ahn KM.
europepmc   +1 more source

A case of attempted bilateral self-enucleation in a patient with bipolar disorder

Mental Illness, 2017
Attempted and completed self-enucleation, or removal of one’s own eyes, is a rare but devastating form of self-mutilation behavior. It is often associated with psychiatric disorders, particularly schizophrenia, substance induced psychosis, and bipolar ...
Hannah Muniz Castro, John Alvarez, Robert G. Bota, Marc Yonkers, Jeremiah Tao   +4 more
doaj   +1 more source

The Role of Video-EEG Monitoring in Lesch-Nyhan Syndrome. [PDF]

Maedica (Bucur), 2023
Roza E, Baloi AD, Plaiasu V, Teleanu RI.
europepmc   +1 more source

Oral Self-Mutilation in Lesch-Nyhan Syndrome: A Case Report. [PDF]

Cureus, 2022
Ferrão J, Rodrigues Barros C, Figueiredo L, Fernandes A.   +3 more
europepmc   +1 more source