Results 171 to 180 of about 22,625 (246)

Research Progress on Anti‐Inflammatory Adipokine SFRP5‐Mediated Lipid Metabolism and Its Potential Role in Neural Development

Immunity, Inflammation and Disease, Volume 14, Issue 6, June 2026.
ABSTRACT Objective To systematically review the structural features of secreted frizzled‑related protein 5 (SFRP5) and its dual regulation of canonical/non‑canonical Wnt signaling, analyze its association with metabolic disorders, and specifically explore the role and mechanisms of the SFRP5–lipid metabolism axis in neural and optic nerve development ...
Qianfang Jia, Zihan Li, Tianyi Yang, Weihua Yang, Wei Chi   +4 more
wiley   +1 more source

Tissue clock-guided prediction and intervention of futile recanalization: towards precision therapy in mechanical thrombectomy. [PDF]

Front Neurol
Wu Y, Liu B, Ma J, Zhao X.
europepmc   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

Cardiovascular exercise mitigates reperfusion failure and persistent hypoperfusion in the thrombin model of stroke and thrombolysis. [PDF]

J Cereb Blood Flow Metab
Middleham W, Binder NF, Deseö J, Weber R, Zolotko K, Droux J, Yoshihara H, Wyss MT, Luft AR, Weber B, Razansky D, El Amki M, Wegener S.   +12 more
europepmc   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, Volume 2, Issue 2, June 2026.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

Early Post-Thrombectomy MRI Markers: Temporal Evolution and Association With Reperfusion and Clinical Outcome. [PDF]

Neurology
Luby ML, Hsia AW, Somani S, Lomahan CA, Kim Y, Burton SP, Craft V, Thomas LC, Uche V, Dhawan A, Hildreth M, Pajunar M, Sowers B, Cabatbat R, Kline M, De Vis JB, Merino JG, Wright CB, Lynch JK, Gottesman RF, Latour LL.   +20 more
europepmc   +1 more source

Therapeutic Effect of Zingerone on Reproductive Damage in Diabetic Male Rats: Potential Role of Sirt1/Nrf2/HO‐1 and Bax/Bcl‐2 Signaling Pathways

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
Diabetes mellitus causes significant damage to the male reproductive system. Sirt1/Nrf2/HO‐1 signaling pathway acts as a line of defense against ROS in reproductive organs. In STZ‐induced diabetic rats, the proapoptotic Bax protein expression was found to be elevated, whereas the antiapoptotic Bcl‐2 protein expression was reduced.
Edanur Güler Ekmen, Mehmet Çay, İbrahim Halil Güngör, Ali Osman Çeribaşı   +3 more
wiley   +1 more source

Clinical benefit of tenecteplase despite failed recanalization in late-window ischemic stroke: a post hoc analysis of the TRACE-3 trial. [PDF]

BMC Med
Lu Z, Wang Z, Jin A, Che F, Wang L, Zhou L, Dai H, Liu X, Cao Z, Wang L, Hao M, Ye W, Xiong Y, Wang Y.   +13 more
europepmc   +1 more source

Successful Emergent Surgical Repair of Post-Myocardial Infarction Ventricular Septal Rupture With Cardiogenic Shock. [PDF]

JACC Case Rep
Braga Lima MM, Maia da Silva W, Aguiar JF, Poppi NT, Vilela de Salis LV, Zoé de Medeiros Brito J, Veronese ET, Diniz Freire AF, Soares PR, Scudeler TL.   +9 more
europepmc   +1 more source