Results 41 to 50 of about 23,892 (247)

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, EarlyView.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source

Recovery Potential after Acute Stroke

Frontiers in Neurology, 2015
In acute stroke the major factor for recovery is the early use of thrombolysis aimed at arterial recanalization and reperfusion of ischemic brain tissue.
Rüdiger Jürgen Seitz, Rüdiger Jürgen Seitz, Geoffrey Allan Donnan   +2 more
doaj   +1 more source

Neuroprotective efficacy of methylene blue in ischemic stroke: an MRI study. [PDF]

PLoS ONE, 2013
Methylene blue (MB) has unique energy-enhancing and antioxidant properties and is FDA-approved drug to treat methemoglobinemia and cyanide poisoning.
Qiang Shen, Fang Du, Shiliang Huang, Pavel Rodriguez, Lora Talley Watts, Timothy Q Duong   +5 more
doaj   +1 more source

Inmunosupresión en donantes renales [PDF]

, 2012
La lesión por isquemia y reperfusión (IRI) es uno de los principales problemas en el trasplante. Nuestro objetivo fue evaluar el efecto del pre - acondicionamiento al donante con rapamicina y tacrolimus para prevenir la lesión por IRI.
Cicora, Federico, Gonzalez, Pedro Horacio, Guerrieri, Diego, Lausada, Natalia, Raimondi, Clemente, Roberti, Javier, Stringa, Pablo   +6 more
core  

Nature‐Inspired Surface Modification Strategy Reverses the Autophagic Flux Impairment of Mitochondrial Transplantation for Attenuating Ischemic Strokes

Advanced Science, EarlyView.
The functionalized starch modifies the mitochondrial surface and encapsulates resveratrol into the cavity of helices, facilitating a novel mitochondrial transplantation platform (MLSR). Upon internalization in recipient cells, MLSR triggers mitophagy and maintains positive autophagic flux through RIP1/RIP3 pathway inhibition.
Nisha Wang, Qiyang Ding, Lei Shi, Ji Xia, Shuyue Zhang, Chenxin Jian, Yixiao Yan, Xiuhua Luo, Jiarui Wang, Ming Cheng, Yiqiong Jia, Hao Tian, Wei Gao   +12 more
wiley   +1 more source

El papel del estrés oxidativo en la disfunción endotelial de la aterosclerosis [PDF]

, 2010
La enfermedad cardiovascular es una causa importante de morbilidad y mortalidad en el mundo. Resulta de la oclusión trombótica de las arterias como consecuencia de la rotura de una placa de ateroma, misma que se genera por disfunción endotelial e ...
AMAYA CHAVEZ, ARACELI, AMAYA CHAVEZ, ARACELI, DOMINGUEZ GARCIA, MA. VICTORIA, DOMINGUEZ GARCIA, MA. VICTORIA, JIMENEZ ROSALES, ANGELICA, JIMENEZ ROSALES, ANGELICA   +5 more
core  

Decoding the Cardiac Immune Microenvironment and Fibroblast Crosstalk in Radiotherapy Combined with Immunotherapy‐Induced Cardiac Fibrosis Based on Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
This study highlights that radioimmunotherapy drives crosstalk between fibroblasts and immune cells (especially macrophages) in the cardiac microenvironment, with IL‐6 as the key mediator, and tocilizumab alleviates cardiac fibrosis by targeting this interplay.
Yuxi Luo, Ying Yu, Zhimin Zeng, Yanxin Chen, Yali Yi, Zhiqin Lu, Fujuan Zeng, Peng Xu, Daya Luo, Leifeng Chen, Anwen Liu   +10 more
wiley   +1 more source

Lesion Volume as a Predictor of Return to Work After Stroke

Cerebral Circulation - Cognition and Behavior
Introduction: Facilitating a successful return to work plays a pivotal role in reintegrating stroke survivors into the community. This study aims to explore the significance of lesion volume in the acute phase of stroke as a predictor for returning to ...
Gisle Berg Helland, Mona Beyer, Brian Enriquez, Hege Ihle-Hansen, Håkon Ihle-Hansen, Stein Andersson, Helle Stangeland, Bettina Ujhelyi, Guri Hagberg, Hanne Harbo, Anne Hege Aamodt, Einar August Høgestøl   +11 more
doaj   +1 more source

INFARTO AGUDO DE MIOCARDIO EN LOS CENTROS MÉDICOS DE DIAGNÓSTICO INTEGRAL DEL ESTADO TRUJILLO / Acute myocardial infarction at the comprehensive Diagnostic Medical Centers of Trujillo state [PDF]

, 2012
ResumenIntroducción y objetivos: Las enfermedades cardiovasculares constituyen la primera causa de muerte en los países desarrollados, y el infarto agudo de miocardio, es su expresión fundamental.
Humberto L. Ramos González, Virginia Concepción González   +1 more
core  

Integrative Approaches to Treating Cellular Senescence in Kidney Disease

Advanced Science, EarlyView.
ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa, Amruta A, LaTonya J. Hickson, Joy Wolfram   +3 more
wiley   +1 more source