Results 51 to 60 of about 22,625 (246)

Estudio de la obstrucción microvascular y el proceso de fibrosis en el infarto de miocardio reperfundido [PDF]

, 2018
El presente trabajo, que se dividió en tres partes, pretendió caracterizar dos aspectos importantes en la fisiopatología tras un infarto agudo de miocardio (IAM) como son la obstrucción microvascular (OMV) y la formación de la cicatriz fibrótica.
Hervás Lorente, Arantxa
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NET‐DNA Activates the ANXA2/TMEM215/BiP Axis to Promote Mitophagy‐Mediated Anoikis Resistance in Endometriosis

Advanced Science, EarlyView.
NET‐DNA is enriched during early endometriotic lesion establishment and drives anoikis resistance by promoting an ANXA2–TMEM215–BiP axis. This pathway strengthens ER–mitochondria contacts, enhances PINK1/Parkin‐associated mitophagy, preserves mitochondrial homeostasis, and supports ectopic stromal cell survival, thereby facilitating lesion persistence ...
Honglin Wang, Yanling Gou, Huiyan Zhang, Hongli Wang, Beidi Wang, Jinming Liu, Yingying Cao, Ruru Bai, Yuxin Zhao, Xu Han, Chao Feng, Xin Huang, Zongfeng Zhang   +12 more
wiley   +1 more source

Efectos de la inhibición de la desacetilación de las histonas en el remodelado post-infarto del sustrato arritmogénico [PDF]

, 2021
Se ha investigado, en un modelo de infarto crónico (seis semanas) en conejo, el efecto de un inhibidor de las desacetilasas de histonas, el ácido valproico, sobre la magnitud del miocardio infartado y sobre determinadas propiedades electrofisiológicas y ...
Genovés, Patricia
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Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Intérêt du Macaca fascicularis avec occlusion de l’artère cérébrale moyenne pour étudier la récupération fonctionnelle post-AVC ischémique : étude de cas

Revue de Primatologie
This case study explores early changes in cerebral perfusion after ischemic stroke induced by middle cerebral artery occlusion in a non-human primate model, in order to identify imaging markers predictive of functional recovery.
Julie Maulavé, Justine Debatisse, Océane Wateau, Omer Faruk Eker, Emmanuelle Canet-Soulas, Léon Tremblay   +5 more
doaj   +1 more source

All trans-retinoic acid protects against acute ischemic stroke by modulating neutrophil functions through STAT1 signaling

Journal of Neuroinflammation, 2019
Background and purpose Regulation of neural inflammation is considered as a vital therapeutic target in ischemic stroke. All-trans retinoic acid (atRA), a potent immune modulator, has raised interest in the field of stroke therapy.
Wei Cai, Julie Wang, Mengyan Hu, Xiao Chen, Zhengqi Lu, Joseph A. Bellanti, Song Guo Zheng   +6 more
doaj   +1 more source

PSICOICTUS: avaluació i pronòstic de les alteracions afectives i cognitives després d’un ictus minor. Abordatge translacional [PDF]

, 2023
L’ictus és una malaltia freqüent que es considera la primera causa de discapacitat i la segona causa de demència a Espanya. L’ictus minor (IM) és un tipus d’ictus isquèmic que es defineix com un episodi de simptomatologia neurològica focal que no causa ...
Pereira Priego, Cristina
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Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

Higher Blood Pressure during Endovascular Thrombectomy in Anterior Circulation Stroke Is Associated with Better Outcomes [PDF]

Journal of Stroke, 2018
Background and Purpose Reports investigating the relationship between in-procedure blood pressure (BP) and outcomes in patients undergoing endovascular thrombectomy (EVT) due to anterior circulation stroke are sparse and contradictory.
Slaven Pikija, Vladimir Trkulja, Christian Ramesmayer, Johannes S. Mutzenbach, Monika Killer-Oberpfalzer, Constantin Hecker, Nele Bubel, Michael Ulrich Füssel, Johann Sellner   +8 more
doaj   +1 more source

Influence of systemic and myocardial metabolism on post-ischemic heart recovery [PDF]

, 2015
El corazón es un órgano que por su incesante actividad contráctil requiere un elevado y continuoaporte de energía, que sólo se logra mediante el metabolismo aeróbico que ocurre en la mitocondria.Para mantener la función cardíaca y satisfacer la alta ...
Hermann, Romina, Varela, Alicia, Marina Prendes, María Gabriela   +2 more
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