Results 71 to 80 of about 22,625 (246)

Endogenous antioxidants, clinical laboratory variables and immunosuppressants in recipients of functioning renal transplants

, 2022
Introducción: los efectos deletéreos de la uremia, de las terapias sustitutivas temporarias y de la medicación inmunosupresora y el accionar sobredimensionado del estrés oxidativo en receptores de trasplante renal acarrean ateroesclerosis acelerada ...
Cruz Abascal, Rafael Enrique, Heredia Ruiz, Danay, Fernández Caraballo, Douglas   +2 more
core   +1 more source

Molecular mechanism of ischemic postconditioning in promoting diabetic ischemic brain injury repair via the microRNA‐34a–BDNF–SIX3 signaling axis

Animal Models and Experimental Medicine, EarlyView.
Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Ling Zhao, Chunlan Zou, Junxian Li, Yang Yang, Yuanyuan Han, Tingyu Ke   +5 more
wiley   +1 more source

The Protective Effects of Atorvastatin on the Brain Injury and Neuronal Damage caused by Ischemia-reperfusion in Rats

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2015
  BACKGROUND AND OBJECTIVE: Stroke is the third main cause of mortality and the most important origin of disability in the world. Atorvastatin has been shown to have strong anti-inflammatory and antioxidant effects on various pathological ...
M Aslani, MT Mohammadi, J Raouf Sarshoori   +2 more
doaj  

Trasplante hepático experimental en el cerdo con donante a corazón parado. Efecto de diversas modificaciones de la bomba de derivación cardiopulmonar durante la recirculación sobre la viabilidad del injerto hepático. [PDF]

, 2009
[spa] Los donantes a corazón parado (DCP) tratados con recirculación normotérmica (RN) para revertir la lesión por isquemia caliente (IC) se han mostrado como una alternativa válida para paliar el déficit de órganos para el trasplante a nivel clínico y ...
Santos Cidón, Pilar
core  

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Hyperacute Interleukin‐1β Production and Neutrophil Extracellular Trap Formation in the Cerebral Circulation of Stroke Patients with Large Vessel Occlusion

Annals of Neurology, EarlyView.
Acute ischemic stroke due to large vessel occlusion is associated with rapid intravascular immune activation. Analysis of arterial blood sampled distal to the thrombus during mechanical thrombectomy revealed increased extracellular adenosine triphosphate (ATP) and interleukin‐1β (IL‐1β) levels, evidence of inflammasome priming in monocytes, and ...
Justine Münsterberg, Caspar Brekenfeld, Hanna Englert, Marius Piepke, Regine J. Dress, Martin Oertel, Tina Fischer, Romy Hackbusch, Mingming Zha, Haodi Cai, Christian Casar, Ines S. Schädlich, Leo Winter, Alina Jander, Karoline Degenhardt, Maxim Bester, Fabian Flottmann, Uta Hanning, Brigitte Holst, Anna Worthman, Johanna Hiefner, Berenike Rutz, Eckhard Schlemm, Götz Thomalla, Bettina H. Clausen, Ann M. Stowe, Immo Prinz, Thiruma V. Arumugam, Markus Glatzel, Thomas Renné, Jens Fiehler, Eva Tolosa, Tim Magnus, Mathias Gelderblom   +33 more
wiley   +1 more source

Protección de hígados patológicos frente a la lesión y al fallo en la regeneración asociado a la cirugía hepática [PDF]

Programa de Doctorat en Biotecnologia / Tesi realitzada a l'Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)[spa] El hígado es un órgano vital para el organismo por la multitud de funciones que desarrolla.
Rojano Alfonso, Carlos
core   +2 more sources

Inhibition of tPA-induced hemorrhagic transformation involves adenosine A2b receptor activation after cerebral ischemia

Neurobiology of Disease, 2017
Tissue plasminogen activator (tPA) is administered after ischemic stroke to dissolve intravascular clots, but its use can lead to hemorrhagic transformation (HT).
Qiang Li, Xiaoning Han, Xi Lan, Xiaohua Hong, Qian Li, Yufeng Gao, Tianqi Luo, Qingwu Yang, Raymond C. Koehler, Yu Zhai, Jinyuan Zhou, Jian Wang   +11 more
doaj   +1 more source

The unique role of Angiogenin in neuroprotection and neurorepair after cerebral ischemia [PDF]

, 2021
L'ictus és una de les principals causes de mort i discapacitat a tot el món amb un gran impacte socioeconòmic i costos sanitaris. Dades recents mostren que hi ha més de 13 milions de nous ictus anualment, una de cada quatre persones majors de 25 anys ...
Lei, Ting
core  

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source