Results 61 to 70 of about 22,625 (246)

Targeting Dnmt3a/m5C/RelA Axis Attenuates Microglia Inflammatory Response and Improves Postoperative Recovery in Chronic Compressive Cervical Spinal Cord Injury

Advanced Science, EarlyView.
A pro‐inflammatory microglial subset persists after decompression in chronic compressive cervical spinal cord injury and shows enhanced Dnmt3a‐driven m5C signaling. By stabilizing RelA mRNA, this axis sustains NF‐κB activation and postoperative neuroinflammation.
Tianyu Qin, Yuan Jiang, Yongheng Xie, Huanwei Qu, Wenbin Yan, Jingle Chen, Yining Chen, Huayi Li, Naibo Feng, Jiajun Wu, Chao Zhang, Zhengqi Huang, Ming Shi, Zhihuai Deng, Guozhi Xiao, Houqing Long   +15 more
wiley   +1 more source

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Proteção miocárdica pelo pré- e pós-condicionamento anestésico Protección miocárdica por el pre y el poscondicionamiento anestésico Myocardial protection by pre- and post-anesthetic conditioning

, 2008
JUSTIFICATIVA E OBJETIVO: A isquemia miocárdica perioperatória é um evento comumente observado no período perioperatório podendo aumentar significativamente a morbimortalidade pós-cirúrgica. As propriedades cardioprotetoras dos anestésicos voláteis e dos
AULER JR., José Otávio Costa, PASQUALIN, Rubens Campana, Rubens Campana Pasqualin, José Otávio Costa Auler Jr.   +3 more
core   +1 more source

Hipotermia terapéutica en pacientes adultos tras parada cardiorrespiratoria extrahospitalaria. Revisión bibliográfica [PDF]

, 2020
[Resumen] Introducción: En los pacientes que sufren una parada cardiorrespiratoria (PCR) recuperada, se produce una lesión por isquemia-reperfusión denominada síndrome postparada cardíaca (SPP), que puede ocasionar daño neurológico severo e incluso ...
Rojo Corral, Alba
core  

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Mecanismos de señalización en el trasplante hepático de donantes con criterio extendido [PDF]

Programa de Doctorat en Biotecnologia[spa] En la práctica clínica, el trasplante de hígado supone una de las pocas soluciones a enfermedades hepáticas en estado terminal.
Micó Carnero, Marc
core   +2 more sources

Ca2+ oscillation in vascular smooth muscle cells control myogenic spontaneous vasomotion and counteract post-ischemic no-reflow

Communications Biology
Ischemic stroke produces the highest adult disability. Despite successful recanalization, no-reflow, or the futile restoration of the cerebral perfusion after ischemia, is a major cause of brain lesion expansion.
Jinze Li, Yiyi Zhang, Dongdong Zhang, Wentao Wang, Huiqi Xie, Jiayu Ruan, Yuxiao Jin, Tingbo Li, Xuzhao Li, Bingrui Zhao, Xiaoxuan Zhang, Jiayi Lin, Hongjun Shi, Jie-Min Jia   +13 more
doaj   +1 more source

Subacute edema progression after acute ischemic stroke: impact of intravenous alteplase administration and reperfusion degree

Frontiers in Neurology
IntroductionAlteplase is known to increase the risk of blood-brain barrier integrity disruption, potentiating hemorrhage and edema. Evolving edema reduces chances of good functional outcomes.
Wiktor Olszewski, Wiktor Olszewski, Fabiano Cavalcante, Laura van Poppel, Laura van Poppel, Ludo Beenen, Bart J. Emmer, Ido van den Wijngaard, Ido van den Wijngaard, Robin Lemmens, Robin Lemmens, Yvo Roos, Henk Marquering, Henk Marquering, Praneeta Konduri, Praneeta Konduri, Praneeta Konduri, Charles Majoie   +17 more
doaj   +1 more source

Uso de un compuesto para la elaboración de un medicamento destinado al tratamiento de una lesión producida por una reperfusión post-isquémica

, 2009
Uso de un compuesto para la elaboración de un medicamento destinado al tratamiento de una lesión producida por una reperfusión post-isquémica. La presente invención se refiere al uso del compuesto CR-6 (3,4-dihidro-6-hidroxi-7-metoxi-2,2-dimetil-1(2H)
Messeguer Peypoch, Ángel, Planas, Anna M.   +1 more
core  

“Intrapericardial Approach” for Venous Outflow Reconstruction in Living‐Donor Liver Transplantation for Budd‐Chiari Syndrome: Surgical Techniques and LongTerm Outcomes

Annals of Gastroenterological Surgery, EarlyView.
Unlike deceased‐donor liver transplantation, living‐donor liver transplantation (LDLT) for Budd‐Chiari Syndrome (BCS) presents distinctive challenges in hepatic venous (HV)‐outflow reconstruction because diseased HV–inferior vena cava (IVC) cannot be entirely replaced with healthy donor vessels.
Koichiro Hata, Tetsuya Tajima, Satoshi Ogiso, Shinji Uemoto, Etsuro Hatano   +4 more
wiley   +1 more source