Results 61 to 70 of about 23,892 (247)

Molecular mechanism of ischemic postconditioning in promoting diabetic ischemic brain injury repair via the microRNA‐34a–BDNF–SIX3 signaling axis

Animal Models and Experimental Medicine, EarlyView.
Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Ling Zhao, Chunlan Zou, Junxian Li, Yang Yang, Yuanyuan Han, Tingyu Ke   +5 more
wiley   +1 more source

EHI neonatal: LEM, o el premio a la supervivencia [PDF]

, 2005
Aún en un marco molecular y bioquímico actual muy complejo, y en un contexto de isquemia, la principal causa de lesión del sistema nervioso central en el feto y el recién nacido continúa siendo la falta de aporte de oxígeno a los tejidos.La etiopatogenia
Jones, Marta
core  

DNase1 RS1053874 Polymorphism is Associated with Early Neurological Recovery through NET Modulation and with Long‐Term Survival in Ischemic Stroke: A Prospective Cohort Study

Annals of Neurology, EarlyView.
Objective Immunothrombosis contributes to ischemic stroke pathophysiology through neutrophil extracellular trap (NET) formation, which promotes thrombus stabilization and microvascular dysfunction. DNase1 is the principal endonuclease responsible for NET degradation.
B. Díaz‐Benito, P. Calleja, L. Alzamora, A. Ruiz‐García, A. Martínez‐Salio, M. Muñoz‐García, F. Ostos, A. García‐Culebras, A. Moraga, M.A. Moro, I. Lizasoain   +10 more
wiley   +1 more source

Individualized Treatment in Distal and Medium Vessel Occlusion Stroke Using a Validated Explainable Counterfactual Treatment Estimation Model

Annals of Neurology, EarlyView.
Objective The optimal treatment for distal medium vessel occlusion (DMVO) stroke remains uncertain, and evidence comparing endovascular therapy (EVT) with medical management (MM) is limited. We aimed to develop and validate a predictive modeling tool to assess individual treatment benefit in DMVO stroke using explainable counterfactual treatment ...
Mohamed F. Doheim, Mahmoud H. Mohammaden, Hend Abdelhamid, Marta Olive‐Gadea, Marc Rodrigo‐Gisbert, Manuel Requena, Johanna T. Fifi, James E. Siegler, Santiago Ortega‐Gutierrez, Mohamad Abdalkader, Ali Alaraj, Wei Hu, Thanh N. Nguyen, Diogo C. Haussen, Raul G. Nogueira   +14 more
wiley   +1 more source

Ca2+ oscillation in vascular smooth muscle cells control myogenic spontaneous vasomotion and counteract post-ischemic no-reflow

Communications Biology
Ischemic stroke produces the highest adult disability. Despite successful recanalization, no-reflow, or the futile restoration of the cerebral perfusion after ischemia, is a major cause of brain lesion expansion.
Jinze Li, Yiyi Zhang, Dongdong Zhang, Wentao Wang, Huiqi Xie, Jiayu Ruan, Yuxiao Jin, Tingbo Li, Xuzhao Li, Bingrui Zhao, Xiaoxuan Zhang, Jiayi Lin, Hongjun Shi, Jie-Min Jia   +13 more
doaj   +1 more source

Efecto del dimetilsulfóxido en un modelo de nefrotoxicidad inducida por gentamicina en conejos [PDF]

, 2012
Teniendo en consideración las múltiples teorías fisiopatológicas que sugieren una posible naturaleza multifactorial que pueda explicar en gran medida la nefrotoxicidad inducida por aminoglicósidos y las limitadas evidencias que hasta ahora revelan los ...
Amaya Amaya, Paola Marcela, Anaya Noubleau, Axa Maria Yosmar, López Nuñez, Oscar Francisco   +2 more
core  

Nanomaterial‐Mediated Near‐Infrared Photothermal Neuromodulation for Neurologic Disorders

Advanced NanoBiomed Research, EarlyView.
This review summarizes how near‐infrared light activates photothermal nanomaterials to enable noninvasive neuromodulation with high spatiotemporal precision. It elucidates the underlying mechanisms, explores targeted therapeutic applications for neurological disorders, discusses integration with optogenetics and biosensors, and addresses future ...
Ting‐Ting Zeng, Yu‐Ge Wang, Ya‐Bing Zhang, Yuan‐Xin Bai, Si‐Tong Lin, Ting‐Ting Zhu, Yan‐Bo Zhou, Wei‐Tong Pan, Pan‐Miao Liu, Jian‐Jun Yang   +9 more
wiley   +1 more source

EJVES vol 34, issue 2 (August 2007) - Spanish Translated Abstracts [PDF]

, 2007
Chronic exposure to arsenic (As) through the consumption of contaminated groundwaters is a major threat to public health in South and Southeast Asia. The source of As-affected groundwaters is important to the fundamental understanding of the controls on ...
Ballentine, Christopher J., Boyce, Adrian J., Casanueva-Marenco, Maria J., Magnone, Daniel, Polya, David A., Richards, Laura A., van Dongen, Bart E.   +6 more
core   +2 more sources

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

The Protective Effects of Atorvastatin on the Brain Injury and Neuronal Damage caused by Ischemia-reperfusion in Rats

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2015
  BACKGROUND AND OBJECTIVE: Stroke is the third main cause of mortality and the most important origin of disability in the world. Atorvastatin has been shown to have strong anti-inflammatory and antioxidant effects on various pathological ...
M Aslani, MT Mohammadi, J Raouf Sarshoori   +2 more
doaj