Results 101 to 110 of about 1,344,206 (319)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

CORRELATION ANALYSIS BETWEEN DEPRESSIVE MANIFESTATIONS AND MORPHOLOGICAL LESION CHARACTERISTICS IN PATIENTS WITH STROKE [PDF]

Sanamed, 2014
Introduction: Knowledge of etiopathogenesis of post-stroke depressive phenomena contributes to early diagnostics which shortens recovery to a great extent and suits the social and professional rehabilitation of patients, if followed by proper psycho ...
Stojanovic Zlatan, Vukadinovic Stojanovic Sanja   +1 more
doaj  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

The prognosis of allocentric and egocentric neglect : evidence from clinical scans [PDF]

, 2012
We contrasted the neuroanatomical substrates of sub-acute and chronic visuospatial deficits associated with different aspects of unilateral neglect using computed tomography scans acquired as part of routine clinical diagnosis.
Chechlacz, Magdalena, Lau Johnny K. L., Pia Rotshtein (122796), Chechlacz, Magdalena; id_orcid, Humphreys, Glyn W., Bickerton, Wai-Ling, Roberts, Katherine L, Chechlacz, M, Rotshtein, P, Wai-Ling Bickerton, Bickerton, WL, Lau, JKL, Lau, JK, Humphreys, Glyn W, Humphreys Glyn W., Baron, Jean-Claude, Pia Rotshtein, Johnny K L Lau, Bickerton, W-L, Humphreys, GW, Bickerton Wai-Ling, Roberts, KL, Magdalena Chechlacz (122794), Katherine L. Roberts (122798), Glyn W Humphreys, Lau, Johnny K L, Roberts Katherine L., Rotshtein, Pia, Glyn W. Humphreys (122804), Johnny K. L. Lau (122802), Roberts, Katherine L., Magdalena Chechlacz, Humphreys, Glyn, Chechlacz Magdalena, Lau, Johnny K. L., Katherine L Roberts, Rotshtein Pia, Wai-Ling Bickerton (122800)   +37 more
core   +1 more source

Role of direct vs indirect pathways from the motor cortex to spinal motoneurons in the control of hand dexterity

Frontiers in Neurology, 2013
Evolutionally, development of the direct connection from the motor cortex to spinal motoneurons (corticomotoneuronal (CM) pathway) parallels the ability of hand dexterity.
Tadashi eIsa, Tadashi eIsa, Masaharu eKinoshita, Yukio eNishimura, Yukio eNishimura, Yukio eNishimura   +5 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

A nod to paratuberculosis: NOD1 and NOD2 expression in the pathological spectrum of Mycobacterium avium subsp. paratuberculosis infection in cattle

Frontiers in Veterinary Science
Mycobacterium avium subsp. paratuberculosis causes various types of granulomatous lesions in cattle, ranging from focal lesions associated with latency to diffuse lesions observed in animals with clinical disease.
David Zapico, David Zapico, José Espinosa, José Espinosa, Pedro Mendívil, Pedro Mendívil, Miguel Criado, Miguel Criado, Julio Benavides, Miguel Fernández   +9 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Skin lesion classification enhancement using border-line features – The melanoma vs nevus problem

, 2020
Machine learning algorithms are progressively assuming an important role as a computational tool to support clinical diagnosis, namely in the classification of pigmented skin lesions.
Faria, Sergio M. M., Tavora, Luis M. N., Assuncao, Pedro A. A., Paiva, Rui Pedro, Thomaz, Lucas A., Fonseca-Pinto, Rui, Pereira, Pedro M. M.   +6 more
core   +1 more source

Association between various insulin resistance surrogates and gallstone disease based on national health and nutrition examination survey

Scientific Reports
Previous studies have reported potential associations between insulin resistance (IR) and the occurrence of gallstone disease (GSD). Recently, some novel indexes have been developed and applied for the assessment of IR.
Rui Gong, Yuchen Ding, Kaiqi Yang, Xiaodie Meng, Xiujing Sun   +4 more
doaj   +1 more source