Results 81 to 90 of about 1,344,206 (319)

Protonation of the (6-4) lesion by histidine in DNA repair revisited

, 2023
The harmful pyrimidine-pyrimidone (6-4) lesions in DNA are repaired by a specific photoenzyme DNA 6-4 photolyase (64PL). The repair process combines photoexcitation of the FADH− cofactor with electron transfer (ET) and proton transfer (PT) reactions ...
Tatiana, Domratcheva, Konstantin, Odintsov   +1 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

ХИРУРГИЧЕСКОЕ ЛЕЧЕНИЕ МЕТАСТАТИЧЕСКОГО ПОРАЖЕНИЯ КЛЮЧИЦЫ ПРИ СЕМИНОМЕ (клиническое наблюдение)

, 2017
Clavicle is a very rare localization for primary tumor process as well as for metastatic lesion thereby there are few papers in medical literature dedicated to the surgical treatment of a clavicle tumor lesion.
Dubrovskaya M.V., Zasulsky P.Y., Grigoriev P.V., Mikailov I.M.   +3 more
core   +1 more source

Post-stroke depression and lesion location: a systematic review [PDF]

, 2015
Post-stroke depression (PSD) is a frequent problem in stroke rehabilitation. Several studies have evaluated association between the lesion location and the risk of depression. Different conclusions and contradictory findings have been published.
Yong, Wu, Zhou, Yafan, Wei, Na, Deng, Manfei, Li, Xinyan, Huijuan Jin, Zhu, Houze, Jin, Huijuan   +7 more
core   +1 more source

Endoscopic submucosal dissection (ESD) for gastritis cystica profunda (GCP) with early gastric cancer: A propensity score matching analysis

Heliyon
Background and aim: Cystic dilatation of the gastric glands within the mucosal layer is the hallmark of the rare condition known as gastritis cystica profunda (GCP).
Wei Jiang, Liyi Bai, Shutian Zhang, Rui Cheng   +3 more
doaj   +1 more source

Aphthous lesions

Oral Surgery, Oral Medicine, Oral Pathology, 1972
Oral Surgery, Oral Medicine, Oral Pathology 33 (1972) 407-416. doi:10.1016/0030-4220(72)90470-7 ; Received by publisher: 0000-01-01 ; Harvest Date: 2016-01-04 12:20:32 ; DOI:10.1016/0030-4220(72)90470-7 ; Page Range: 407 ...
College of Dentistry, University of Florida Gainesville, Fla., USA ( host institution ), Stanley, Harold R. ( author )   +1 more
openaire   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The Role of Endoscopic Tattooing in Colorectal Surgery

The intraoperative finding of a lesion, which has already been located previously by endoscopy, can sometimes be a challenge, especially during laparoscopy. Failure to locate the exact place of the lesion can cause the resection of a wrong bowel segment.
Boyanov, Nikola; Medical University of Plovdiv, Madzharova, Katerina; Department of Gastroenterology, Pulmed University Hospital, Plovdiv, Kirkov, Luben; Department of Gastroenterology, Pulmed University Hospital, Plovdiv, Balabanski, Aleksandar; Department of Gastroenterology, Pulmed University Hospital, Plovdiv, Shopov, Neno; Department of Surgery, Pulmed University Hospital, Plovdiv, Yotovski, Asen; Department of Gastroenterology, Pulmed University Hospital, Plovdiv, Shtereva, Katina; Department of Gastroenterology, Pulmed University Hospital, Plovdiv   +6 more
core   +1 more source

Antidepressant fluoxetine alleviates colitis by reshaping intestinal microenvironment

Cell Communication and Signaling
Background The impact of antidepressants on Inflammatory bowel diseases (IBD) has been extensively studied. However, the biological effects and molecular mechanisms of antidepressants in alleviating colitis remain unclear.
Shuo Teng, Yi Yang, Wanru Zhang, Xiangji Li, Wenkun Li, Zilu Cui, Li Min, Jing Wu   +7 more
doaj   +1 more source