Results 71 to 80 of about 1,344,206 (319)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Impact of Storage Lesion on Post-transfusion Rise in Hemoglobin

, 2018
Background: The storage lesion is defined as the set of changes that occur in red blood cells (RBCs) during storage. Studies have shown that a prolonged storage period of RBCs is associated with increased destruction after transfusion.
Anwer, Faiz, Eng, Margaret Hh, Sardar, Muhammad, Khan, Wahab J, Shaikh, Nasreen, Jacob, Aasems, Kelly, David B, Yada, Srujana, Ansell, Jack, Doraiswamy, Mohankumar   +9 more
core   +1 more source

A Circulating miRNA-Based Scoring System Established by WGCNA to Predict Colon Cancer

Analytical Cellular Pathology, 2019
Introduction. Circulation microRNAs (miRNAs) perform as potential diagnostic biomarkers of many kinds of cancers. This study is aimed at identifying circulation miRNAs as diagnostic biomarkers in colon cancer. Methods.
Da Qin, Rui Wei, Si Liu, Shengtao Zhu, Shutian Zhang, Li Min   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Osteonecrosis of the Femoral Head with Collapsed Medial Lesion

, 2014
A 60-year-old female experienced the gradual onset of left hip pain without any triggering event. Radiographs showed vertical sclerosis in the center of the femoral head and the lesion inside the boundary demonstrated diffuse bony sclerosis.
Yukihide Iwamoto, Goro Motomura, Yasuharu Nakashima, Akio Sakamoto, Ryosuke Yamaguchi, Takuaki Yamamoto, Kazuyuki Karasuyama   +6 more
core   +1 more source

Healing of endodontic periodontal lesion after non-surgical treatment

, 2020
Introduction, aim: An endo-perio lesion is one of the common problems associated with the tooth. The simultaneous presence of pulp-related condition and inflammatory periodontal disease can complicate diagnosis and treatment planning.
W. Batbout, E. Hidoussi, H. Sarraj, L. Bhouri, N. Zokkar, N. Douki   +5 more
core   +1 more source

Functional MRI preprocessing in lesioned brains: manual versus automated region of interest analysis

Frontiers in Neurology, 2015
Functional magnetic resonance imaging has significant potential in the study and treatment of neurological disorders and stroke. Region of interest (ROI) analysis in such studies allows for testing of strong a priori clinical hypotheses with improved ...
Kathleen A Garrison, Kathleen A Garrison, Kathleen A Garrison, Corianne eRogalsky, Corianne eRogalsky, Tong eSheng, Brent eLiu, Hanna eDamasio, Carolee J Winstein, Lisa S Aziz-zadeh, Lisa S Aziz-zadeh, Lisa S Aziz-zadeh   +11 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

White Spot Lesion and fixed orthodontics: Evidence on operating protocols before, during, after treatment.

, 2023
noneWhite Spot Lesion e Ortodonzia fissa. Alcuni protocolli clinici come la prevenzione ,remineralizzazione domiciliare e professionale , sbiancamento , infiltrazione resinose
GUMENI, ALTEJA
core  

Analysis of the contour structural irregularity of skin lesions using wavelet decomposition [PDF]

, 2013
The boundary irregularity of skin lesions is of clinical significance for the early detection of malignant melanomas and to distinguish them from other lesions such as benign moles. The structural components of the contour are of particular importance.
Ma, Li, Staunton, Richard C.
core   +1 more source