Results 91 to 100 of about 3,523 (219)

NUDT15 Genetic Polymorphism as a Risk Factor for Early Neutropenia During Valganciclovir Prophylaxis in Lung Transplant Patients

Transplant Infectious Disease, Volume 27, Issue 6, November/December 2025.
ABSTRACT Background Valganciclovir (VGCV) prophylaxis effectively prevents cytomegalovirus infection in lung transplant patients. However, VGCV‐induced neutropenia causes early cessation. Nucleoside diphosphate‐linked moiety X‐type motif (NUDT) 15 degrades the ganciclovir (GCV) triphosphate, an active metabolite.
Yurie Katsube, Keisuke Umemura, Yuzuki Urabe, Miori Ono, Yoshiki Katada, Daiki Hira, Akihiro Ohsumi, Daisuke Nakajima, Masahiro Tsuda, Shunsaku Nakagawa, Tomoyuki Mizuno, Miki Nagao, Hiroshi Date, Tomohiro Terada   +13 more
wiley   +1 more source

Current and Emerging Antiviral Agents in the Prevention and Treatment of Cytomegalovirus in Pediatric Transplant Recipients [PDF]

Despite current prophylaxis regimens, cytomegalovirus (CMV) is common in hematopoietic cell transplantation (HCT) and solid organ transplantation (SOT) and remains a significant cause of morbidity and mortality.
Danziger-Isakov, Lara A, Downes, Kevin J, Valencia Deray, Kristen G   +2 more
core   +2 more sources

Reduced incidence of relapse after checkpoint inhibitors relative to brentuximab vedotin as salvage therapy before allogeneic stem cell transplantation for refractory/relapsed Hodgkin lymphoma: A retrospective analysis

British Journal of Haematology, Volume 207, Issue 4, Page 1684-1689, October 2025.
Eighty‐two patients were eligible for allogeneic transplantation (Allo‐SCT) at our Institution between April 2014 and August 2022. Of these, 72 actually received Allo‐SCT, n = 44 after checkpoint inhibitor (CPI) containing salvage therapy (CPI cohort) and n = 28 with brentuximab‐vedotin (BV) containing therapy without CPI (BV cohort).
Jacopo Mariotti, Chiara Pinton, Laura Giordano, Daniela Taurino, Barbara Sarina, Chiara De Philippis, Daniele Mannina, Cristina Tentori, Armando Santoro, Stefania Bramanti   +9 more
wiley   +1 more source

Usage of Antivirals and the Occurrence of Antiviral Resistance in Norway 2019. RAVN [PDF]

, 2020
The usage of antivirals According to The Norwegian Drug Wholesales statistics database, the sales of antiviral drugs measured in defined daily doses (DDDs) continued to increase in 2018.
Bragstad, Karoline, Kran, Anne-Marte Bakken, Kro, Grete Anette Birkeland, Litleskare, Irene, Rykkvin, Rikard, Stene-Johansen, Kathrine   +5 more
core  

Current Progress in Targeting Human Cytomegalovirus Infection

iLABMED, Volume 3, Issue 3, Page 303-311, September 2025.
This review highlights recent advances in the mechanisms by which human cytomegalovirus (HCMV) maintains its genome in infected cells, as well as the cellular factors and viral antigens that modulate viral reactivation, which reveal potential targets for addressing HCMV infection.
Yonggang Pei, Jun Chen
wiley   +1 more source

Letermovir for the prevention of cytomegalovirus infection and disease in transplant recipients: an evidence-based review

Infection and Drug Resistance, 2019
Guy El Helou,1,2 Raymund R Razonable1,21Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA; 2William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN, USAAbstract ...
El Helou G, Razonable RR
doaj  

Discovery and Characterization of Cytomegalovirus Inhibitors using Reporter-based Antiviral Assays [PDF]

, 2017
DISCOVERY AND CHARACTERIZATION OF CYTOMEGALOVIRUS INHIBITORS USING REPORTER-BASED ANTIVIRAL ASSAYS By Amine Ourahmane, MS A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth ...
ourahmane, amine
core   +1 more source

Defining a CMV viral load threshold for pre‐emptive therapy in paediatric haematopoietic stem cell transplant recipients

British Journal of Haematology, Volume 207, Issue 3, Page 911-919, September 2025.
Cytomegalovirus (CMV) infection and disease are frequent complications following haematopoietic stem cell transplantation (HSCT) in children. A common prevention strategy involves regular monitoring of CMV viral load and initiating antiviral therapy once a predefined threshold is exceeded.
Amedine Duret, Oscar Charles, Ben K. Margetts, John Booth, Julianne R. Brown, Timothy Best, Sneha Fernandes, Persis Amrolia, Robert Chiesa, Juliana Silva, Austen Worth, Joseph F. Standing, Kanchan Rao, Elizabeth Whittaker, Eliza Gil, Judith Breuer   +15 more
wiley   +1 more source

Utility of Serial Microbial Cell-free DNA Sequencing for Inpatient and Outpatient Pathogen Surveillance Among Allogeneic Hematopoietic Stem Cell Transplant Recipients. [PDF]

BACKGROUND: This study characterizes the clinical utility and validity of the Karius test (KT), a plasma microbial cell-free DNA sequencing platform, as an infection surveillance tool among hematopoietic stem cell transplant (HCT) recipients, including ...
Chin-Hong, Peter, DeVoe, Catherine, Dwivedi, Aditya, Fung, Monica, McAdams, Staci, Pamula, Meenakshi, Patel, Nimish, Perkins, Bradley, Ryan, Caitlin, Sam, Srey, Smollin, Matthew, Teraoka, Justin   +11 more
core   +1 more source

Efficacy and safety of letermovir prophylaxis for cytomegalovirus infection after hematopoietic stem cell transplantation

Blood Science
Letermovir is a specific inhibitor of cytomegalovirus (CMV) terminase complex. Several studies have reported that letermovir can effectively prevent CMV activation after allogeneic hematopoietic stem cell transplantation (allo-HSCT). We aimed to identify
Wen-Wen Li, Yong-Mei Zhang, Meng-Zhu Shen, Xiao-Dong Mo   +3 more
doaj   +1 more source