Results 101 to 110 of about 2,984 (199)

The direct and indirect consequences of cytomegalovirus infection and potential benefits of vaccination [PDF]

, 2020
Active infection with cytomegalovirus (CMV) occurs in patients who are immunocompromised and may produce the high viral loads required to cause end-organ disease.
Griffiths, P
core  

Letermovir [PDF]

Reactions Weekly, 2020
openaire   +2 more sources

Safety and efficacy of G-CSF after allogeneic hematopoietic cell transplantation using post-transplant cyclophosphamide: clinical and in vitro examination of endothelial activation [PDF]

Since 2021 the use of G-CSF was implemented in allo-HCT with PTCY-based prophylaxis with the aim of shortening the aplastic phase and reducing infectious complications. This study investigates the effectiveness of this change in protocol performed at our
Carcelero San Martin, Esther, Carreras Pons, Enrique, Charry, Paola, Cid Vidal, Joan, de Moner Rafel, Blanca, Díaz Ricart, Maribel, Escribano-Serrat, Silvia, Fernández-Avilés, Francesc, Garcia Cruz, Eduardo, Gomez Perez, Pilar Begona, Guardia, Laia, Lozano Molero, Miguel, MARTIN, Lidia, Martínez Muñoz, Carmen, Martínez Sánchez, Júlia, Monge-Escartín, Inés, Moreno Guarnido, Cristina, Pedraza, Alexandra, Ramos López, Alex, Riu Viladoms, Gisela, Rovira Tarrats, Montserrat, Salas Gay, María Queralt, Suarez-Lledó Grande, María, Ventosa Capell, Helena   +23 more
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Letermovir and inhibitors of the terminase complex: a promising new class of investigational antiviral drugs against human cytomegalovirus

Infection and Drug Resistance, 2015
Dante P Melendez,1,2 Raymund R Razonable1,2 1Division of Infectious Diseases, 2William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN, USA Abstract: Infection with cytomegalovirus is prevalent in ...
Melendez DP, Razonable RR
doaj  

Optimizing CMV therapy: Population pharmacokinetics and Monte Carlo simulations for letermovir and maribavir dosage.

PLoS ONE
PurposeThis study seeks to reassess and enhance the dosing strategies of letermovir and maribavir for treating cytomegalovirus (CMV) infection, aiming to propose adjustments that could improve therapeutic effectiveness.MethodsPre-existing population ...
Yeleen Fromage, Hamza Sayadi, Sophie Alain, Pierre Marquet, Gilles Peytavin, Jean-Baptiste Woillard   +5 more
doaj   +1 more source

Cost-effectiveness analysis of the use of letermovir for the prophylaxis of cytomegalovirus in adult cytomegalovirus seropositive recipients undergoing allogenic hematopoietic stem cell transplantation in Italy

Infection and Drug Resistance, 2019
Umberto Restelli,1,2 Davide Croce,1,2 Valeria Pacelli,1 Fabio Ciceri,3,4 Corrado Girmenia51Center for Health Economics, Social and Health Care Management, LIUC - Università Cattaneo, Castellanza, VA, Italy; 2School of Public Health, Faculty of ...
Restelli U, Croce D, Pacelli V, Ciceri F, Girmenia C   +4 more
doaj  

CMV-RNAemia as new marker of active viral replication in transplant recipients [PDF]

N
Bonifazi F., Borgatti E. C., Cantiani A., Franceschiello M., Gabrielli L., Giannella M., Gibertoni D., Lanna F., Lazzarotto T., Leone M., Motta V., Pascale R., Pavoni M., Piccirilli G.   +13 more
core   +1 more source

Real-Life Data on the Efficacy and Safety of Letermovir for Primary Prophylaxis of Cytomegalovirus in Allogeneic Hematopoietic Stem Cell Recipients: A Single-Center Analysis

Turkish Journal of Hematology
Objective: Cytomegalovirus (CMV) reactivation is a life-threatening complication after allogeneic hematopoietic stem cell transplantation (HSCT).
Martyna Wlodarczyk, Agata Wieczorkiewicz-Kabut, Krzysztof Białas, Anna Koclęga, Izabela Noster, Patrycja Zielińska, Grzegorz Helbig   +6 more
doaj   +1 more source

Human neural progenitor cell models to study the antiviral effects and neuroprotective potential of approved and investigational human cytomegalovirus inhibitors [PDF]

Human cytomegalovirus (HCMV) is the viral leading cause of congenital defects in newborns worldwide. Many aspects of congenital CMV (cCMV) infection, which currently lacks a specific treatment, as well as the main determinants of neuropathogenesis in the
Apolloni L., Arav-Boger R., Loregian A., Mercorelli B., Onorati M., Palu G., Pianezzola A., Pistello M., Trevisan M.   +8 more
core   +1 more source

Challenges for the improvement of valganciclovir prophylaxis in solid organ transplantation and the possible role of therapeutic drug monitoring in adults [PDF]

Cytomegalovirus (CMV) infection frequently occurs after solid organ transplantation and is associated with an increased morbidity and mortality. Fortunately, the development of valganciclovir prophylaxis has lowered the incidence of CMV infection and its
de Winter, Brenda C.M., Hesselink, Dennis A., van Vugt, Lukas K.   +2 more
core   +1 more source