Results 11 to 20 of about 3,523 (219)

Reversion of Val(Ganciclovir)-Resistance-Associated Mutations in Two SOT Patients with Mismatched Serostatus for CMV (D+/R-) [PDF]

Viruses
The emergence of drug-resistant cytomegalovirus (CMV) complicates viral response to therapy. We present two cases of solid organ transplant (SOT) recipients, highlighting the reversion of UL97 mutations associated with val(ganciclovir) resistance ...
Elena Seminari, Alessandra Tebaldi, Aurelia Sangani, Paola Giordani, Daniele Lilleri, Stefania Paolucci, Giulia Campanini, Elizabeth Iskandar, Fausto Baldanti, Raffaele Bruno   +9 more
doaj   +2 more sources

Human cytomegalovirus control in allogeneic stem cell transplant recipients in the letermovir era – emerging humoral and cellular players

Haematologica
Allogeneic hematopoietic stem cell transplant (alloSCT) recipients frequently experience late-onset human cytomegalovirus (HCMV) reactivations following termination of letermovir prophylaxis.
Chris D. Lauruschkat, Hannah Görge, Kerstin Knies, Benedikt Weißbrich, Lars Dölken, Carolin Köchel, Nina Imhof, Magdalena Huber, Hartmut Hengel, Hermann Einsele, Sebastian Wurster, Sabrina Kraus   +11 more
doaj   +2 more sources

Impact of CMV-specific immune reconstitution at the end of letermovir prophylaxis on the development of late cytomegalovirus infection in haematopoietic stem cell transplant recipients (INMUNOEND): a protocol for a prospective, observational, multicentre study. [PDF]

BMJ Open
Introduction: Cytomegalovirus (CMV) infection is a common complication in patients undergoing haematopoietic stem cell transplantation (SCT). Letermovir (LTV) prophylaxis during the first 100 days post-SCT is effective and safe in preventing this ...
Castón JJ, Aparicio C, Paez-Vega A, Pozo López L, García E, Martín C, Ruiz-Arabi E, Cuesta-Casas MÁ, Bermúdez-Rodriguez MA, Cerezo-Martín JM, González-Sierra PA, Machuca I, Martín Domínguez FM, Saldaña-Moreno R, Herrera C, Torre-Cisneros J.   +15 more
europepmc   +3 more sources

Letermovir Prophylaxis for Cytomegalovirus Infection in Allogeneic Stem Cell Transplantation: A Real-World Experience [PDF]

, 2021
Attolico, I., Bruno, B., Busca, A., Canale, F. A., Carella, A. M., Carluccio, P., Cerchione, C., Cimminiello, M., Colasante, F., Crescimanno, A., Di Renzo, N., Federico, V., Ferreri, A., Giaccone, L., Gori, M., Ingrosso, C., Leotta, S., Loteta, B., Marotta, S., Martinelli, G., Martino, M., Mazza, P., Merla, E., Mordini, N., Musso, M., Musto, P., Musuraca, G., Pastore, D., Paviglianiti, A., Picardi, A., Pitino, A., Porto, G., Prezioso, L., Pugliese, M., Scalone, R., Selleri, C., Serio, B., Storti, G., Tringali, S., Tripepi, G., Vacca, A.   +40 more
core   +2 more sources

Identification of a binding pocket of letermovir in the terminase subunit pUL56 of human cytomegalovirus [PDF]

Scientific Reports
A key step in replication of human cytomegalovirus (HCMV) is the generation and packaging of unit-length genomes into preformed capsids. The enzymes involved in this process are viral terminases.
Lukas M. Kmetsch, Hans Tietze, Elke Bogner   +2 more
doaj   +2 more sources

Optimizing CMV therapy: Population pharmacokinetics and Monte Carlo simulations for letermovir and maribavir dosage. [PDF]

PLoS ONE
PurposeThis study seeks to reassess and enhance the dosing strategies of letermovir and maribavir for treating cytomegalovirus (CMV) infection, aiming to propose adjustments that could improve therapeutic effectiveness.MethodsPre-existing population ...
Yeleen Fromage, Hamza Sayadi, Sophie Alain, Pierre Marquet, Gilles Peytavin, Jean-Baptiste Woillard   +5 more
doaj   +2 more sources

A novel strategy for the management of cytomegalovirus retinitis in immunocompromised patients using new anti-cytomegalovirus drugs [PDF]

Frontiers in Medicine
ObjectivesThis study presents four cases of cytomegalovirus retinitis (CMVR) managed using a novel antiviral strategy, aiming to preliminarily assess its efficacy and safety profile.MethodsA retrospective chart review was conducted on four patients ...
Yuou Yao, Qiaozhu Zeng, Yaoyao Sun, Enzhong Jin, Jiyang Tang, Yi Cai, Jing Hou, Heng Miao   +7 more
doaj   +2 more sources

Integrated Life Cycle Assessment Guides Sustainability in Synthesis: Antiviral Letermovir as a Case Study. [PDF]

J Am Chem Soc
Folkerts S, Hoepfner MG, Guillén-Gosálbez G, Pérez-Ramírez J, Carreira EM.   +4 more
europepmc   +3 more sources

POSSIBILITIES OF PREVENTION AND TREATMENT OF HUMAN CYTOMEGALOVIRUS INFECTIONS INCLUDING NEW DRUGS AND COMPOUNDS WITH POTENTIAL APPLICATION [PDF]

Postępy Mikrobiologii, 2019
Anna Majewska, Beata Młynarczyk-Bonikowska, Magdalena Malejczyk, Sławomir Majewski, Grażyna Młynarczyk   +4 more
doaj   +4 more sources

P-2108. Clinical Outcome differences in Kidney Transplant Patients Receiving Letermovir Versus Valganciclovir for CMV Prophylaxis [PDF]

Open Forum Infect Dis
YoungYoon Ham, Ali Olyaei, Ismael Aguirre   +2 more
europepmc   +3 more sources