Results 31 to 40 of about 2,984 (199)

CMV Preventive and Treatment Studies in Children Undergoing Haematopoietic Stem Cell Transplant: A Systematic Review. [PDF]

Rev Med Virol
ABSTRACT Cytomegalovirus (CMV) is one of the most important infectious causes of morbidity and mortality in children undergoing haematopoietic stem cell transplant (HSCT). However, the evidence for preventing and treating CMV disease in children in this context remains limited. We sought to review the current available evidence regarding the prevention
Fusani L, Fusco E, Fonseca M, Breuer J, Rao K, Galli L, Bamford A, Kadambari S.   +7 more
europepmc   +2 more sources

No Evidence of a Drug-Drug Interaction Between Letermovir (MK-8228) and Mycophenolate Mofetil [PDF]

, 2015
Introduction: Letermovir (MK-8228) is a potent, oncedaily inhibitor of the cytomegalovirus (CMV) terminase complex that is being developed for the prophylaxis of CMV infection in transplant patients. This study evaluated the pharmacokinetic interactions,
Badshah, C., Butterton, JR, Cho, CR., Colon-Gonzalez, F., Hulskotte, E., Kraft, MD, Walter K., Liu, F., Marcantonio, EE, Marshall, WL, Schanke, A. van   +9 more
core   +2 more sources

Estimation of the worldwide seroprevalence of cytomegalovirus : a systematic review and meta-analysis [PDF]

, 2019
Cytomegalovirus (CMV) infection does not usually produce symptoms when it causes primary infection, reinfection, or reactivation because these three types of infection are all controlled by the normal immune system.
Anderholm, Arvin, Bate, Boeckh, Buerkner, Cannon, Cannon, Deayton, Emery, Gkrania-Klotsas, Griffiths, Griffiths, Guerra, Hyde, Institute of Medicine Committee to Study Priorities for Vaccine Development, Kempen, Kenneson, Kharfan-Dabaja, Lilleri, Marty, Moher, Pass, Pembrey, Plotkin, Revello, Richardson, Rubin, Sabbaj, Simanek, Slyker, Vries, Wimperis   +31 more
core   +2 more sources

Changes in subcellular localization reveal interactions between human cytomegalovirus terminase subunits [PDF]

, 2012
BACKGROUND: During herpesvirus replication, terminase packages viral DNA into capsids. The subunits of herpes simplex virus terminase, UL15, UL28, and UL33, assemble in the cytoplasm prior to nuclear import of the complex.
McVoy, Michael A., Parris, Deborah S., Wang, Jian Ben, Zhu, Yali   +3 more
core   +2 more sources

Letermovir prophylaxis for cytomegalovirus reactivation in children who underwent hematopoietic stem cell transplantation: A single-institute experience in Taiwan

Journal of Microbiology, Immunology and Infection, 2022
From January 2019 to May 2021, 11 children underwent allogeneic stem cell transplantation at our institute. Four of them received letermovir for cytomegalovirus prophylaxis.
Chao-Neng Cheng, Sin-Syue Li, Yun-Hsuan Yeh, Ching-Fen Shen, Jiann-Shiuh Chen   +4 more
doaj   +1 more source

Autologous adoptive T-cell therapy for recurrent or drug-resistant cytomegalovirus complications in solid organ transplant patients: a single-arm open-label phase I clinical trial [PDF]

, 2018
BACKGROUND: Opportunistic infections including cytomegalovirus (CMV) are a major cause of morbidity and mortality in solid organ transplant (SOT) recipients.
Beagley, Leone, Campbell, Scott, Chambers, Daniel, Crooks, Pauline, Francis, Ross, Holmes, Mark, Holmes-Liew, Chien-Li, Hopkins, Peter, Khanna, Rajiv, McKenzie, Scott, Neller, Michelle A., Rehan, Sweera, Smith, Corey, Solomon, Matthew   +13 more
core   +1 more source

Population pharmacokinetics of letermovir following oral and intravenous administration in healthy participants and allogeneic hematopoietic cell transplantation recipients

CPT: Pharmacometrics & Systems Pharmacology, 2021
Letermovir is indicated for prophylaxis of cytomegalovirus infection and disease in allogeneic hematopoietic stem cell transplant (HSCT) recipients. Two‐stage population pharmacokinetic (PK) modeling of letermovir was conducted to support dose rationale ...
Marita Prohn, Anders Viberg, Da Zhang, Kevin Dykstra, Casey Davis, Sreeraj Macha, Philip Sabato, Dinesh deAlwis, Marian Iwamoto, Craig Fancourt, Carolyn R. Cho   +10 more
doaj   +1 more source

Enantioselective aza-Michael Cyclization Reaction Catalyzed by Quinine-Derived Monoquaternary Ammonium Salts: an Effective Route to Synthesize Letermovir

Pharmaceutical Fronts, 2021
A series of mono- or bis-quaternary ammonium salts derived from cinchonidine or quinine was synthesized and screened as potent phase-transfer catalysts for the reaction of aza-Michael cyclization, the key step in the synthesis of letermovir.
Liang Chen, Wei-Yuan Liu, Si-Ju Bi, Ting Zhou, Jing Pan, Xun-Lei Lv, Kuai-Le Lin, Wei-Cheng Zhou   +7 more
doaj   +1 more source

Large-scale screening of HCMV-seropositive blood donors indicates that HCMV effectively escapes from antibodies by cell-associated spread [PDF]

, 2018
Immunoglobulins are only moderately effective for the treatment of human cytomegalovirus (HCMV) infections, possibly due to ineffectiveness against cell-associated virus spread.
Alt, Mira, Falk, Jessica, Krawczyk, Adalbert, Laib Sampaio, Kerstin, Lotfi, Ramin, Paal, Caroline, Schrezenmeier, Hubert, Sinzger, Christian, Stanton, Richard, Winkelmann, Martina   +9 more
core   +2 more sources

Cost-effectiveness of letermovir as cytomegalovirus prophylaxis in adult recipients of allogeneic hematopoietic stem cell transplantation in Hong Kong [PDF]

, 2020
Background: The cost-effectiveness of letermovir as cytomegalovirus (CMV) prophylaxis in adult seropositive patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT), compared with the conventional strategy of preemptive treatment ...
Alsumalli, A, Chan, TSY, Chau, RWY, Chen, WT, Cheng, SSY, Hsu, DC, Kang, SH, Kwong, YL   +7 more
core   +1 more source