Results 131 to 140 of about 5,585,699 (313)

Protective efficacy of an inactivated vaccine against Rabbit hemorrhagic disease virus 2 prepared from a local isolate in Egypt

VacciMonitor, 2020
Rabbit hemorrhagic disease is a contagious viral disease of rabbits controlled by vaccination. The present study was aimed to diagnose rabbit hemorrhagic disease from 11 infected farms from Qalubia governorate during 2019 and to prepare homologous ...
Ola Y. Abido, Mahmoud M. Abotaleb, Nahed Yehia, Ayman H. El-Deeb, Aziza M. Amer, Ahmed A. El-Sanousi   +5 more
doaj  

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Hormetic growth of Pinus pseudostrobus seedlings exposed to low-dose gamma and X-ray irradiation

Journal of Forest Science
Mexico ranks among the countries with the highest deforestation rates, increasing the demand for high-quality forest seedlings of valuable species such as Pinus pseudostrobus Lindl., which face germination limitations due to seed dormancy and low ...
Laura Yasmin Flores López, César Valenzuela Encinas, Eulogio De la Cruz Torres, María de Lourdes Palafox Chávez, Ivar Diego Aceves Sánchez, Lourdes Georgina Iglesias Andreu   +5 more
doaj  

Establishing In Vitro Screening Protocols Based on Phenotypic Plasticity of Amaranthus dubius and Galinsoga parviflora Seeds for Drought, Salinity, and Heat Tolerance

International Journal of Plant Biology
The vulnerability of commercial crops under a changing climate has led scientists to consider wild crop species as alternative food sources. The aim of this study was to identify plastic physiological and morphological traits that could be used to in ...
Candyce Ann Areington, Martha M. O’Kennedy, Sershen   +2 more
doaj   +1 more source

Acute toxicity effects of ethylene glycol on lethal dose 50 (LD50), urine production, and histopathology change renal tubule cell in mice.

Open veterinary journal
The LD50 (lethal dose causing 50% mortality) of ethylene glycol (EG) and its associated toxicity in mice (Mus musculus) were assessed by evaluating kidney function.This study aimed to determine the acute toxicity of an oral lethal dose of 50% (LD50) of EG, also degeneration, necrosis, and inflammatory cell invasion in kidney tubules of male rats ...
Dewa Ketut Meles, Imam Mustofa, Wurlina Wurlina, Clarissa Audreylea Donova, Essi Rayareswari Hidayanti, Niluh Suwasanti, Zulfi Nur Amrina Rosyada, Aswin Rafif Khairullah, Adeyinka Oye Akintunde, Rheza Imawan Mustofa, Satriawan Wedniyanto Putra, Riza Zainuddin Ahmad, Wasito Wasito, Ricadonna Raissa   +13 more
openaire   +3 more sources

Immediate Growth Control in Response to Boiling Histotripsy is Prognostic for Intratumoral Immune Activation

Advanced Science, EarlyView.
Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger, Matthew R. DeWitt, Carly M. Van Wagoner, Claire A. Conarroe, Charles C. Funk, Aaron B. Streit, AeRyon Kim, Richard J. Price, Timothy N. J. Bullock   +8 more
wiley   +1 more source

Median lethal dose (1x GPIMLD₅₀ listed in MIPLD₅₀ units) for male guinea pigs 400-500g.

, 2019
Median lethal dose (1x GPIMLD50 listed in MIPLD50 units) for male guinea pigs 400-500g.
Shantha Kodihalli (630152), Karen Gillum (6199490), Andrew Emanuel (4610887), Teresa Takla (4610884), Nancy Neimuth (6199493), Hongyu Qiu (317690), Douglas Barker (6199487)   +6 more
core   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source