Results 191 to 200 of about 731,605 (329)

Bimetallic Peroxide Nanocomposites‐Driven Redox Dyshomeostasis to Activate Sequential Cuproptosis and Pyroptosis for Amplified Tumor Immunotherapy

Advanced Science, EarlyView.
Hyaluronic acid‐modified bimetallic peroxide nanocomposites (MgO2‐CuO2@HA) are designed for synergistic tumor therapy. The nanocomposites release Mg2+, H2O2, and Cu2+ in tumor cells, induce cuproptosis via Cu+‐mediated protein aggregation, and activate pyroptosis through caspase‐1/gasdermin D pathways for inducing immunogenic cell death, collectively ...
Guanting He, Haixia Zhu, Peipei Kang, Lili Feng, Chenghao Yu, Yanlin Zhu, Bin Liu, Zhengxiao Guo, Piaoping Yang   +8 more
wiley   +1 more source

Neonicotinoid-induced signature dysbiosis identified via metagenomic sequencing of the honey bee gut microbiome. [PDF]

Sci Rep
Tran L, Deckers TB, Ho J, Lansing L, Cunningham M, Morfin N, Pepinelli M, De la Mora A, Conflitti IM, Gregoris A, Wu L, Trepanier-Leroux D, Muntz L, Newman T, Vishwakarma S, Bixby M, Jabbari H, Guzman-Novoa E, Hoover SE, Currie RW, Pernal SF, Giovenazzo P, Foster LJ, Zayed A, Ortega Polo R, Guarna MM.   +25 more
europepmc   +1 more source

PERKECAMBAHAN DAN LD50 (LETHAL DOSE 50) BAWANG PUTIH KULTIVAR DOULU YANG DIRADIASI SINAR GAMMA [PDF]

, 2018
Delima Lisma Simbolon, Tumiur Gultom
openalex  

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source

Near-UVA Radiation at 405 nm: Germicidal Effect With and Without Sub-Lethal Conditions on <i>Gram</i>-Positive and <i>Gram</i>-Negative Bacteria. [PDF]

Pathogens
Amodeo D, Pedrazzoli G, Palma I, Puccio A, Trillocco G, Papale G, Cevenini G, Tani M, Messina G.   +8 more
europepmc   +1 more source

Dipiperazine‐Phenyl Derivatives Based on Convergent Molecular Platforms Can Reverse Multidrug Resistance in Gram‐Negative Bacteria by Inhibiting Efflux and Permeabilizing Cell Membranes

Advanced Science, EarlyView.
By integrating a convergent molecular platform strategy, this study designed a novel dual‐target C5 to combat multidrug‐resistant Gram‐negative bacteria. C5 synergistically enhances antibiotic efficacy by inhibiting efflux pumps and increasing bacterial membrane permeability.
Jiale Dong, Ting Guo, Yi Huang, Yangchun Ma, Weijin Chen, Jie Xue, Jun Jiang, Enhui Dong, Yue Kong, Hang Ding, Wenlong Zhang, Shutao Ma   +11 more
wiley   +1 more source

Repellent, Lethal Activity, and Synergism of <i>Cannabis sativa</i> Extracts with Terpenes Against a Laboratory Colony of <i>Triatoma infestans</i>. [PDF]

Plants (Basel)
Dadé MM, Daniele MR, Rodriguez S, Díaz P, Silvestrini MP, Schinella GR, Marin GH, Barrio D, Prieto Garcia JM.   +8 more
europepmc   +1 more source

Host‐Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules

Advanced Science, EarlyView.
Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun, Sumin Son, JinAh Lee, Minha Lee, Meehyun Ko, Songrui Zhao, Ju Hee Kim, Kannan Vaithegi, Ji Hoon Kwon, Jung Ho Lee, Sangeun Jeon, Dawon Yi, Peng Zou, Seungtaek Kim, Seung Bum Park   +14 more
wiley   +1 more source

Determination of the Lethal Concentrations of Two Phenolic Acid Derivatives Originated From the Edible Red Marine Macroalga (<i>Bangia fuscopurpurea</i>) Using the In Vivo Zebrafish Eleutheroembryo Model and Their In Silico Structure-Toxicity Relationship Study. [PDF]

Food Sci Nutr
Huang SY, Li G, Shih YJ, Hsieh CW, Lin YS, Liu J, Sun T, Feng CW.   +7 more
europepmc   +1 more source

Acute paraquat poisoning: report of a survival case following intake of a potential lethal dose.

Pediatric emergency care, 2006
R. Dinis-Oliveira, A. Sarmento, Paulo Reis, A. Amaro, F. Remião, M. Bastos, F. Carvalho   +6 more
semanticscholar   +1 more source