Results 201 to 210 of about 731,605 (329)

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

Comparison of Adjuvant Potency of Alum, AddaVax, and ISA 71 VG on the Seasonal Split Influenza Vaccine in Mice. [PDF]

Microorganisms
Wu L, Yang R, Wu H, Yang B, Zhang X, Tao Y, Wu X, Li S, Shu J, He Y, Feng H.   +10 more
europepmc   +1 more source

Metabolic Reprogramming of T Cells by Dual UCP2 and IL‐17 Blockade Enhances Immunity Against Pancreatic Cancer

Advanced Science, EarlyView.
This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu, Chun‐Chieh Yeh, Tsai‐Chen Wu, Chia‐Hsin Lin, Yi‐Ting Kuo, Yoichiro Iwakura, Yuan‐Ji Day, Charles Drake, Vedran Radojcic, Ying‐Chyi Song, Heng‐Hsiung Wu, Hung‐Rong Yen   +11 more
wiley   +1 more source

DHerbKB for CKD: knowledge base of diet and toxic herbal medicines for clinical support of chronic kidney disease. [PDF]

J Transl Med
Wang HY, Yuan C, Zhao YH, Yi Y, Chen YN, Li Y, Chang D, Lin X, Wang J, Tang SCW, Wang Q, Chen M.   +11 more
europepmc   +1 more source

Lung carcinomas in Sprague-Dawley rats after exposure to low doses of radon daughters, fission neutrons, or γ-rays [PDF]

, 1989
Chameaud, J., Chmelevsky, D., Kellerer, Albrecht M., Lafuma, J., Masse, R., Morin, M.   +5 more
core   +1 more source

WDR5‐H3K4me3 Epigenetic Axis Promotes TRMT6‐Dependent tRNA M1A Modification to Facilitate Triple‐Negative Breast Cancer Progression by Suppressing Ferroptosis

Advanced Science, EarlyView.
Upregulated TRMT6 forms aberrant hypermethylation of a specific tRNA pool and serves as a predictor of poor prognosis in TNBC. This m1A modification in tRNAs enhances translation of FTH1 and FTL, reducing the pool of bioavailable Fe2⁺. Reduced Fe2+ availability impairs RSL3‐induced lipid peroxidation and tumor progression.
Yuqing Lei, Xue Wang, Jiahe Liu, Zixu Niu, Jiaqi Hua, Qian Guo, Dan Du, Yuanchang Zhu, Fucheng He, Mingxia Zhou, Hongle Li, Jing He, Jun Li   +12 more
wiley   +1 more source

The deletion of the EP402R and MGF505/360 genes attenuates a genotype I/II recombinant ASFV but fails to confer complete protection against homologous or genotype II challenge in pigs. [PDF]

Emerg Microbes Infect
Li Y, Liu Y, Sun Z, Xie Z, Tian C, Wang R, Gao J, Wang M, Liu J, Wang H, Zhang G, Li J, Di D, Gong L, Chen H.   +14 more
europepmc   +1 more source

Lethal dose 50 percent ld 50 to staphylococcus aureus nctc 8530 in mice bearing ehrlich's tumor

, 1990
A. O. C. Jorge, Sandra Vieira, JF Höfling, O. P. De-Almeida   +3 more
openalex   +1 more source

USE OF LETHAL DOSE TEMPERATURE ESTIMATES AS INDICES OF FROST TOLERANCE FOR WHEAT COLD ACCLIMATED UNDER NATURAL AND CONTROLLED ENVIRONMENTS

, 1973
M. Pomeroy, D. Fowler
semanticscholar   +1 more source

Temporal changes in tissue repair permit survival of diet-restricted rats from an acute lethal dose of thioacetamide.

Toxicological Sciences, 1998
Shashi K. Ramaiah, Thomas J. Bucci, Alan A Warbritton, Madhusudan G. Soni, H. Mehendale   +4 more
semanticscholar   +1 more source