Results 221 to 230 of about 731,605 (329)

A multivalent nanobody-drug conjugate to prevent and treat influenza virus infections. [PDF]

Proc Natl Acad Sci U S A
Harmand TJ, Pietrok L, Rich H, Deshycka R, Flanagan L, Accardo A, Pishesha N, Ploegh HL.   +7 more
europepmc   +1 more source

Nap1L4a Cooperates with Scl/Klf1 to Recruit H2A.Z in Mediating Interactions Among Cis‐Regulatory Elements and Transcription Required for Primitive Erythropoiesis in Zebrafish

Advanced Science, EarlyView.
Nap1l4a is required in erythropoiesis and hypoxia responses via physical interaction with Klf1 and Scl to recruit the histone variant H2A.Z. This facilitates its associated cis‐regulatory element (CRE) remodeling and the consequent chromatin assembly, and activates the transcription of erythroid lineage‐specific genes.
JiaHao Shi, FuMing Lai, Zheng Shen, XiaoYan Zhang, HanFei Wang, WenYe Liu, YunLong Wang, KuanYu Li, GuoLiang Li, YaPing Fang, Jing‐Xia Liu   +10 more
wiley   +1 more source

Fast-acting single-dose vesicular stomatitis virus-Sudan virus vaccine: a challenge study in macaques. [PDF]

Lancet Microbe
Fletcher P, O'Donnell KL, Feldmann F, Rhoderick JF, Clancy CS, Haase JA, Prator CA, Smith BJ, Gunn BM, Feldmann H, Marzi A.   +10 more
europepmc   +1 more source

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

ATP burst is the dominant driver of antibiotic lethality in <i>Mycobacterium smegmatis</i>. [PDF]

Elife
Lodhiya T, Palande A, Veeram A, Larrouy-Maumus GJ, Beste DJV, Mukherjee R.   +5 more
europepmc   +1 more source

PDIA3 Inhibition Facilitates Sensitivity of IKE‐Induced Ferroptosis via STAT3/LCN2 Axis to Improve Glioblastoma Therapy

Advanced Science, EarlyView.
In this manuscript, protein disulfide isomerase A3 (PDIA3) is identified as a key factor mediating the susceptibility of ferroptosis in GBM. Inhibition of PDIA3 enhances IKE or cystine starvation‐induced ferroptosis in GBM cells by resulting in the accumulation of lipid peroxidation and a reduction in GSH level.
Jie Zhang, Wei Wang, Xin Liu, Peifen Lu, Xinjing Liu, Qiucheng Nie, Siyuan Xin, Hong Li, Donglin Yu, Xinyue Zhang, Kailong Li, Xiaomin Han, Shuping Zhang, Wei Chong, Lili Sun, Wei Li, Tao Xin, Jin Jiao, Qiang Ma, Yiju Wei   +19 more
wiley   +1 more source

A single-cycle recombinant VSV vaccine displaying the Hendra virus glycoprotein uniformly protects against Hendra and Nipah virus challenge. [PDF]

NPJ Vaccines
Pigeaud DD, Borisevich V, Agans KN, Harrison MB, O'Toole R, Martinez J, Dobias NS, Woolsey C, Fenton KA, Geisbert TW, Cross RW.   +10 more
europepmc   +1 more source

Killing Them Softly: Mediations on a Painful Punishment of Death [PDF]

, 2008
Blecker, Robert
core   +1 more source

Uncoupling Metastasis and Epithelial‐to‐Mesenchymal Transition in sgP19/kRAS‐Driven Spontaneous Metastatic Liver Tumor Model

Advanced Science, EarlyView.
The article first reported that a murine mixed typical intrahepatic cholangiocarcinoma (iCCA)/sarcomatoid iCCA liver tumor model with 100% incidence of spontaneous extrahepatic metastasis and confirmed the occurrence of in mouse iCCA. Most importantly, EMT induced by the TGF‐β/ZEB1 axis does not influence tumor development or distant metastasis in this
Jingwen Wang, Zijing Xu, Lei Xu, Lishan Wang, Jiahao Geng, Xue Wang, Meng Xu, Daphne Superville, Melissa Reeves, Matthias Evert, Diego F. Calvisi, Xin Chen, Xinhua Song   +12 more
wiley   +1 more source

Assessing the oral toxicity of acetamiprid, spinosad, cypermethrin, and pyrethrins in the invasive hornet Vespa velutina nigrithorax. [PDF]

Sci Rep
Malaquias Souto P, Santos SS, Sarmento A, de Liz Ronsani A, Tomaz AL, Azevedo-Pereira HMVS, Leston S, Ramos F, Sousa JP, Capela N.   +9 more
europepmc   +1 more source