Results 21 to 30 of about 4,473,042 (255)
Two Genetically Defined Tram-Acting Loci Coordinately Regulate Overlapping Sets of Liver-Specific Genes [PDF]
, 1990 Mice homozygous for deletions around the albino locus fail to activate expression of a set of neonatal liver functions and die shortly after birth. This phenotype is thought to result from the loss of a positive trans-acting factor, denoted alf, in ...
Boshart, Michael +5 more
core +1 more source
Inhibitors of the Metalloproteinase Anthrax Lethal Factor [PDF]
Current Topics in Medicinal Chemistry, 2016 Bacillus anthracis, a rod shaped, spore forming, gram positive bacteria, is the etiological agent of anthrax. B. anthracis virulence is partly attributable to two secreted bipartite protein toxins, which act inside host cells to disrupt signaling pathways important for host defense against infection.
Allison B, Goldberg, Benjamin E, Turk
openaire +2 more sources
Toxins, 2017 The anthrax lethal toxin consists of protective antigen (PA) and lethal factor (LF). Understanding both the PA pore formation and LF translocation through the PA pore is crucial to mitigating and perhaps preventing anthrax disease.
Alexandra J. Machen +10 more
doaj +1 more source
Anthrax lethal factor cleaves mouse nlrp1b in both toxin-sensitive and toxin-resistant macrophages. [PDF]
PLoS ONE, 2012 Anthrax lethal factor (LF) is the protease component of anthrax lethal toxin (LT). LT induces pyroptosis in macrophages of certain inbred mouse and rat strains, while macrophages from other inbred strains are resistant to the toxin.
Kristina A Hellmich +8 more
doaj +1 more source
Membranes, 2016 Tethered lipid bilayer membranes (tBLMs) have been used in many applications, including biosensing and membrane protein structure studies. This report describes a biosensor for anthrax toxins that was fabricated through the self-assembly of a tBLM with B.
Vitalii Silin +5 more
doaj +1 more source
Role of N-terminal amino acids in the potency of anthrax lethal factor. [PDF]
PLoS ONE, 2008 Anthrax lethal factor (LF) is a Zn(+2)-dependent metalloprotease that cleaves several MAPK kinases and is responsible for the lethality of anthrax lethal toxin (LT). We observed that a recombinant LF (LF-HMA) which differs from wild type LF (LF-A) by the
Pradeep K Gupta +4 more
doaj +1 more source
Phage Display Analysis of Monoclonal Antibody Binding to Anthrax Toxin Lethal Factor
Toxins, 2017 AVR1674 and AVR1675 are monoclonal antibodies (mAbs) that bind with high specificity to anthrax toxin lethal factor (LF) and lethal toxin (LTx).
Jason M. Goldstein +6 more
doaj +1 more source
Biosensors, 2021 Anthrax lethal factor (LF) is one of the enzymatic components of the anthrax toxin responsible for the pathogenic responses of the anthrax disease. The ability to screen multiplexed ligands against LF and subsequently estimate the effective kinetic rates
Allison M. Marn +3 more
doaj +1 more source
Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF). Potential role in asthma [PDF]
, 1998 Macrophage migration inhibitory factor (MIF) is a potent proinflammatory mediator that has been shown to potentiate lethal endotoxemia and to play a potentially important regulatory role in human acute respiratory distress syndrome (ARDS).
N Hirani +15 more
core +1 more source
Participation of endogenous tumour necrosis factor α in host resistance to cytomegalovirus infection [PDF]
, 1993 Interferon gamma (IFN) represents an essential cytokine involved in murine cytomegalovirus (MCMV) clearance from the salivary gland and the control of horizontal transmission.
Crnkovic, Irena +5 more
core +1 more source