Results 191 to 200 of about 321,306 (256)

DIXDC1 Promotes Lymphatic Metastasis and Resistance to Cuproptosis in Bladder Cancer Through Mediating DLAT

Advanced Science, EarlyView.
DIXDC1 drives bladder cancer progression by binding and stabilizing DLAT. This axis enhances NEK7 and CCNE2 mRNA stability to promote proliferation and lymphatic metastasis, while limiting copper‐induced DLAT oligomerization to reduce cuproptosis sensitivity, identifying DIXDC1 as a potential target linking metastasis with cuproptosis resistance ...
Hongqiong Li, Liang Cheng, Xiaole Lu, Haonan Dong, Shi Fu, Hongjin Shi, Mingsheng Liu, Chenwei Yang, Yuhang Huang, Zehua Chen, Yawei Zhang, Kaiwen Jie, Xiaoyue Zhang, Xiang Kui, Xinni Ye, Siting Chen, Xu Chen, Haifeng Wang   +17 more
wiley   +1 more source

High-Risk Rhabdomyosarcomas Feature a Convergent Cell State. [PDF]

Cancer Res
Whitfield HJ, Anderson ND, Burke C, Groot Koerkamp MJ, Parks C, Ogbonnah T, Wood Y, Piapi A, Robertson E, Watt E, White A, De Noon S, Kennedy J, Nagrecha R, Meister MT, Aladowicz E, Man YKS, Laspidea V, Trinh MK, Hodder A, Porter T, Lawrence JE, Tuck E, Nguyen T, Kelsey A, Flanagan AM, Hewitt R, Smeulders N, Slater O, Hutchinson JC, Sebire N, Shipley JM, Drost J, Straathof K, Behjati S.   +34 more
europepmc   +1 more source

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

Molecular basis and therapeutic potential of sortase A inhibitors as new antibiotics against MDR pathogens. [PDF]

Open Biol
Dash A, LaRock C.
europepmc   +1 more source

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Inhibitors of anthrax lethal factor

Bioorganic & Medicinal Chemistry Letters, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Brandon D, Gaddis, Larisa V, Avramova, Jean, Chmielewski   +2 more
openaire   +2 more sources

Factor Structure of a Lethal Behaviors Scale

Psychological Reports, 1987
Factor analysis of a lethal behaviors scale that had been completed by 399 adolescents and adults indicates that lethality as a construct is multidimensional. Principal factors include a general orientation toward danger and violence, an orientation toward bravery and adventure, thrill-seeking and fast driving, and safe or unsafe habits.
J A, Thorson, F C, Powell
openaire   +2 more sources

Various factors affecting the lethality of cyclohexylamine

Toxicology and Applied Pharmacology, 1972
Abstract Cyclohexylamine (CHA) is a metabolite of the artificial sweetening agent cyclamate and has been shown to possess sympathomimetic actions like those of tyramine and/or amphetamine. Acute toxicity studies using male albino Swiss Webster mice indicated that CHA lethality is both temperature and aggregation dependent. Toxic doses of CHA produced
I P, Lee, R L, Dixon
openaire   +2 more sources

CONSIDERATION OF THE LETHAL FACTORS IN ACUTE PANCREATITIS

Archives of Surgery, 1951
IN THE 10-year period 1941-1950 inclusive, there were 164 cases of admission for acute pancreatitis to the Cincinnati General Hospital. In each case the diagnosis was based on at least one of the following criteria: (1) a consistent clinical history in conjunction with increased serum amylase; (2) surgical observation, and (3) postmortem examination ...
V E, SILER, J H, WULSIN
openaire   +2 more sources