Results 21 to 30 of about 326,608 (291)

Anthrax lethal factor inhibition [PDF]

Proceedings of the National Academy of Sciences, 2005
The primary virulence factor of Bacillus anthracis is a secreted zinc-dependent metalloprotease toxin known as lethal factor (LF) that is lethal to the host through disruption of signaling pathways, cell destruction, and circulatory shock.
W L, Shoop, Y, Xiong, J, Wiltsie, A, Woods, J, Guo, J V, Pivnichny, T, Felcetto, B F, Michael, A, Bansal, R T, Cummings, B R, Cunningham, A M, Friedlander, C M, Douglas, S B, Patel, D, Wisniewski, G, Scapin, S P, Salowe, D M, Zaller, K T, Chapman, E M, Scolnick, D M, Schmatz, K, Bartizal, M, MacCoss, J D, Hermes   +23 more
openaire   +2 more sources

Rapid and Sensitive Multiplex Assay for the Detection of B. anthracis Spores from Environmental Samples

Pathogens, 2020
: Prompt and accurate detection of Bacillus anthracis spores is crucial in the event of intentional spore dissemination in order to reduce the number of expected casualties.
Efi Makdasi, Orly Laskar, Itai Glinert, Ron Alcalay, Adva Mechaly, Haim Levy   +5 more
doaj   +1 more source

Current understanding of Bacillus anthracis toxin molecules organization and approaches for blocking their cytotoxic action

Инфекция и иммунитет, 2020
Here, we review the data on mechanisms inhibiting cytotoxic effect of anthrax toxin on the immune system cells. Various disease forms, immunopathogenesis and contemporary methods for anthrax treatment are discussed.
V. V. Firstova, I. G. Shemyakin, I. A. Dyatlov   +2 more
doaj   +1 more source

Designed Azolopyridinium Salts Block Protective Antigen Pores In Vitro and Protect Cells from Anthrax Toxin [PDF]

, 2013
Background:Several intracellular acting bacterial protein toxins of the AB-type, which are known to enter cells by endocytosis, are shown to produce channels.
Barth, Holger, Anika Bronnhuber, Benz, Roland, Hajós György, Markus Huber-Lang, Hajós, György, Kerstin Duscha, Riedl Zsuzsanna, Beitzinger, Christoph, Riedl, Zsuzsanna, Duscha Kerstin, György Hajós, Huber-Lang Markus, Beitzinger Christoph, Barth Holger, Duscha, Kerstin, Bronnhuber, Annika, Benz Roland, Christoph Beitzinger, Roland Benz, Holger Barth, Bronnhuber Anika, Bronnhuber, Anika, Huber-Lang, Markus, Zsuzsanna Riedl   +24 more
core   +1 more source

The Power of Genomic in situ Hybridization (GISH) in Interspecific Breeding of Bulb Onion (Allium cepa L.) Resistant to Downy Mildew (Peronospora destructor [Berk.] Casp.)

Plants, 2019
We exploited the advantages of genomic in situ hybridization (GISH) to monitor the introgression process at the chromosome level using a simple and robust molecular marker in the interspecific breeding of bulb onion (Allium cepa L.) that is resistant to ...
Ludmila Khrustaleva, Majd Mardini, Natalia Kudryavtseva, Rada Alizhanova, Dmitry Romanov, Pavel Sokolov, Grigory Monakhos   +6 more
doaj   +1 more source

Consequences and Utility of the Zinc-Dependent Metalloprotease Activity of Anthrax Lethal Toxin

Toxins, 2010
Anthrax is caused by the gram-positive bacterium Bacillus anthracis. The pathogenesis of this disease is dependent on the presence of two binary toxins, edema toxin (EdTx) and lethal toxin (LeTx). LeTx, the major virulence factor contributing to anthrax,
Jennifer Bromberg-White, Chih-Shia Lee, Nicholas Duesbery   +2 more
doaj   +1 more source

Crystal structure of the anthrax lethal factor [PDF]

Nature, 2001
Lethal factor (LF) is a protein (relative molecular mass 90,000) that is critical in the pathogenesis of anthrax. It is a highly specific protease that cleaves members of the mitogen-activated protein kinase kinase (MAPKK) family near to their amino termini, leading to the inhibition of one or more signalling pathways.
Pannifer, A. D., Wong, Thiang Yian, Schwarzenbacher, R., Renatus, M., Petosa, C., Bienkowska, J., Lacy, D. B., Collier, R. John, Park, Sukjoon, Leppla, S. H., Hanna, Philip C., Liddington, R. C.   +11 more
openaire   +3 more sources

Design and use of a novel substrate for simple, rapid, and specific early detection of anthrax infection. [PDF]

PLoS ONE, 2018
Bacillus anthracis is a major biological warfare threat. The inhalation form of infection can kill quickly. While antibiotic treatment is effective, if diagnosis is delayed, the rapidly produced toxin may already be present in lethal amounts. This report
Kayana Suryadi, Nancy Shine
doaj   +1 more source

Two Genetically Defined Tram-Acting Loci Coordinately Regulate Overlapping Sets of Liver-Specific Genes [PDF]

, 1990
Mice homozygous for deletions around the albino locus fail to activate expression of a set of neonatal liver functions and die shortly after birth. This phenotype is thought to result from the loss of a positive trans-acting factor, denoted alf, in ...
Boshart, Michael, Bosch, Franz X., Ruppert, Siegfried, Schmidt, Walter, Schlitz, Günther, Fournier, R. E. Keith   +5 more
core   +1 more source

Passive Immunotherapy Protects against Enteric Invasion and Lethal Sepsis in a Murine Model of Gastrointestinal Anthrax

Toxins, 2015
The principal portal for anthrax infection in natural animal outbreaks is the digestive tract. Enteric exposure to anthrax, which is difficult to detect or prevent in a timely manner, could be exploited as an act of terror through contamination of human ...
Bruce Huang, Tao Xie, David Rotstein, Hui Fang, David M. Frucht   +4 more
doaj   +1 more source