Results 101 to 110 of about 4,883,974 (289)

Species and strain differences in the lethal factor of the mouse submandibular gland

, 1977
The differences in susceptibility of animals to the lethal factor extracted from the mouse submandibular gland and magnitude of its lethality were compared among various species, strains, ages, and sex of mice.
Y. T. Kim, K. Hoshino, J. C.-C. Huang, F. S. Chebib   +3 more
core   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Trim72 is a major host factor protecting against lethal Candida albicans infection.

PLoS Pathogens
Candida albicans is the most common aetiologic pathogen of fungal infections associated with high mortality in immunocompromised patients. There is an urgent need to develop new antifungal therapies owing to the poor efficacy and resistance of current ...
Wang Tan, Jiayu Liu, Renlin Yu, Ping Zhao, Yuhan Liu, Qian Lu, Ke Wang, Hao Ding, Yi Liu, Xiaofei Lai, Ju Cao   +10 more
doaj   +1 more source

Access to means of suicide, occupation and the risk of suicide: a national study over 12 years of coronial data

BMC Psychiatry, 2017
Background Availability of lethal means is a significant risk factor for suicide. This study investigated whether occupations with greater access to lethal means had higher suicide rates than those without access, and further, whether this relationship ...
A Milner, K Witt, H Maheen, AD LaMontagne   +3 more
doaj   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Anthrax lethal toxin exerts potent metabolic inhibition of the cardiovascular system

mBio
Bacillus anthracis causes anthrax through a combination of bacterial infection and toxemia. As a major virulence factor of B. anthracis, anthrax lethal toxin (LT) is a zinc-dependent metalloproteinase, exerting its cytotoxicity through proteolytic ...
Jie Liu, Zehua Zuo, Rasem Fattah, Toren Finkel, Stephen H. Leppla, Shihui Liu   +5 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

The Animal Welfare Consequences and Moral Implications of Lethal and Non-Lethal Fox Control Methods

Control methods are applied worldwide to reduce predation on livestock by European red foxes (Vulpes vulpes). Lethal methods can inflict suffering; however, moral debate about their use is lacking.
Andrew Knight, de Ridder, Nathalie, Knight, Andrew, Nathalie de Ridder   +3 more
core   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Efficient synthetic inhibitors of anthrax lethal factor

, 2005
Inhalation anthrax is a deadly disease for which there is currently no effective treatment. Bacillus anthracis lethal factor (LF) metalloproteinase is an integral component of the tripartite anthrax lethal toxin that is essential for the onset and ...
J. W. SMITH, T. Y. Wong, D. V. ROZANOV, R. FATTORUSSO, R. A. ABAGYAN, R. C. LIDDINGTON, A. Y. SAVINOV, B. BECATTINI, D. Jung, FORINO, MARTINO, A. J. ORRY, W. LI, S. JOHNSON, A. Y. STRONGIN, M. PELLECCHIA, K. Alibek   +14 more
core   +2 more sources