Results 21 to 30 of about 315,576 (254)
Consequences and Utility of the Zinc-Dependent Metalloprotease Activity of Anthrax Lethal Toxin
Toxins, 2010 Anthrax is caused by the gram-positive bacterium Bacillus anthracis. The pathogenesis of this disease is dependent on the presence of two binary toxins, edema toxin (EdTx) and lethal toxin (LeTx). LeTx, the major virulence factor contributing to anthrax,
Jennifer Bromberg-White +2 more
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Crystal structure of the anthrax lethal factor [PDF]
Nature, 2001 Lethal factor (LF) is a protein (relative molecular mass 90,000) that is critical in the pathogenesis of anthrax. It is a highly specific protease that cleaves members of the mitogen-activated protein kinase kinase (MAPKK) family near to their amino termini, leading to the inhibition of one or more signalling pathways.
Pannifer, A. D. +11 more
openaire +3 more sources
Design and use of a novel substrate for simple, rapid, and specific early detection of anthrax infection. [PDF]
PLoS ONE, 2018 Bacillus anthracis is a major biological warfare threat. The inhalation form of infection can kill quickly. While antibiotic treatment is effective, if diagnosis is delayed, the rapidly produced toxin may already be present in lethal amounts. This report
Kayana Suryadi, Nancy Shine
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Toxins, 2015 The principal portal for anthrax infection in natural animal outbreaks is the digestive tract. Enteric exposure to anthrax, which is difficult to detect or prevent in a timely manner, could be exploited as an act of terror through contamination of human ...
Bruce Huang +4 more
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Family Relationship In Gabrielle Lord`s Lethal Factor
Lingua Cultura, 2007 Jenis karya sastra cerita detektif bukan hal baru dalam kesusastraan Australia. Salah satu penulis cerita detektif, Gabrielle Lord, menampilkan masalah yang tidak pernah diangkat oleh penulis lainnya, yaitu masalah hubungan keluarga.
Ruth Sri Kinanti
doaj +3 more sources
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2021 Introduction: Anthrax is a zoonotic disease and vaccine production is one way to protect people against this bacterium. This study investigates the application of copolymer nanocapsule (PEG-PLA) systems with controlled release specificity for a ...
Hossein Honari +3 more
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Capturing the transcription factor interactome in response to sub-lethal insecticide exposure
Current Research in Insect Science, 2021 The increasing levels of pesticide resistance in agricultural pests and disease vectors represents a threat to both food security and global health. As insecticide resistance intensity strengthens and spreads, the likelihood of a pest encountering a sub ...
Victoria A Ingham +3 more
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Screening inhibitors of anthrax lethal factor [PDF]
Nature, 2002 The disease anthrax is caused by lethal factor, an enzyme component of the toxin produced by the spore-forming bacterium Bacillus anthracis. Here we describe substrate molecules for this factor that offer a means for high-throughput screening of potential inhibitors for use in anthrax treatment.
TONELLO, FIORELLA +4 more
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Anthrax lethal factor cleaves mouse nlrp1b in both toxin-sensitive and toxin-resistant macrophages. [PDF]
PLoS ONE, 2012 Anthrax lethal factor (LF) is the protease component of anthrax lethal toxin (LT). LT induces pyroptosis in macrophages of certain inbred mouse and rat strains, while macrophages from other inbred strains are resistant to the toxin.
Kristina A Hellmich +8 more
doaj +1 more source