Results 191 to 200 of about 315,576 (254)

Targeting NRF2 addiction in cancer: synthetic lethal strategies beyond direct inhibition. [PDF]

Front Cell Dev Biol
Gebru MT, Stokoe D.
europepmc   +1 more source

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

TRIM47: molecular characteristics, disease-related mechanisms, and clinical translational value. [PDF]

Front Immunol
Wang Q, Zhuo X, Wang X, Luo T, Yin J.
europepmc   +1 more source

ARGLU1 in Glioma: A Novel Potential Regulator of Splicing, DNA Repair, and Therapeutic Resistance. [PDF]

Cells
Wu X, Yi D, Tie D, Du M, Wang M, Yu Z, Xu Y.   +6 more
europepmc   +1 more source

Is access to euthanasia drugs and moral stress linked to suicide rates in veterinarians? A cross-sectional national survey and network analysis. [PDF]

Front Psychiatry
Rymaszewska J, Fila-Pawłowska K, Szcześniak D, Hildebrand W, Pawłowska E, Magdziarz M.   +5 more
europepmc   +1 more source

Fatty Acid Profiling of Fish Fin Tissues: Implications for Non-Lethal Sampling Methods. [PDF]

Ecol Evol
Comeau L, Rehman A, Phillips B, Hay J, Swanson A, Samways KM.   +5 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Inhibitors of anthrax lethal factor

Bioorganic & Medicinal Chemistry Letters, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Brandon D, Gaddis, Larisa V, Avramova, Jean, Chmielewski   +2 more
openaire   +2 more sources

Various factors affecting the lethality of cyclohexylamine

Toxicology and Applied Pharmacology, 1972
Abstract Cyclohexylamine (CHA) is a metabolite of the artificial sweetening agent cyclamate and has been shown to possess sympathomimetic actions like those of tyramine and/or amphetamine. Acute toxicity studies using male albino Swiss Webster mice indicated that CHA lethality is both temperature and aggregation dependent. Toxic doses of CHA produced
I P, Lee, R L, Dixon
openaire   +2 more sources

CONSIDERATION OF THE LETHAL FACTORS IN ACUTE PANCREATITIS

Archives of Surgery, 1951
IN THE 10-year period 1941-1950 inclusive, there were 164 cases of admission for acute pancreatitis to the Cincinnati General Hospital. In each case the diagnosis was based on at least one of the following criteria: (1) a consistent clinical history in conjunction with increased serum amylase; (2) surgical observation, and (3) postmortem examination ...
V E, SILER, J H, WULSIN
openaire   +2 more sources