Results 221 to 230 of about 4,564,003 (287)

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

Tissue‐Agnostic Cellular Morphometric Biomarkers for Risk‐Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers

Advanced Science, EarlyView.
An interpretable, unsupervised artificial intelligence framework identifies a 13‐cellular morphometric biomarker (CMB) signature from routine H&E whole‐slide images. Validated across 2,602 patients, the fixed signature generalizes across colorectal, gastric, and esophageal tissues without retraining, stratifies prognosis and precancerous lesion risk ...
Pin Wang, Chengfei Jiang, April W. Mao, Qi Sun, Yijun Lu, Jingjing Wei, Jamie L. Inman, Susan E. Celniker, Antoine M. Snijders, David W. Threadgill, Allan Balmain, Bo Hang, Hang Chang, Lei Wang, Jian‐Hua Mao   +14 more
wiley   +1 more source

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

Advanced Science, EarlyView.
Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song, Can Zhao, Qiaoling Wang, Hongjiao Zhang, Xiao Liu, Linqi Wang, Michael Bromley, Wen‐Bing Yin   +7 more
wiley   +1 more source

Synthetic lethality in TP53-mutant acute myeloid leukemia. [PDF]

Blood Adv
Patel SA.
europepmc   +1 more source

Dual regulation of autophagy: paradoxical effects on tumor angiogenesis. [PDF]

Front Cell Dev Biol
Xiang S, Gong X, Zhou J, Qiu T, Lan Y, Zhang Z, Ji Y.   +6 more
europepmc   +1 more source

Understanding Rurality and Associated Suicide Risks: Perspectives of Adolescents and Caregivers. [PDF]

Acad Pediatr
Allen SE, Gasper G, Leavitt HB, Pogue JA, Helmling AC, Hernandez NG, Jacobs E, Vanderwiel SL, Cantwell HM, Velmineti V, Sierpe A, Westlund Scheiner M, Hughes JL, Finn CT, Kapadia A, Rutman MS, Leyenaar JK.   +16 more
europepmc   +1 more source

Factor Structure of a Lethal Behaviors Scale

Psychological Reports, 1987
Factor analysis of a lethal behaviors scale that had been completed by 399 adolescents and adults indicates that lethality as a construct is multidimensional. Principal factors include a general orientation toward danger and violence, an orientation toward bravery and adventure, thrill-seeking and fast driving, and safe or unsafe habits.
J A, Thorson, F C, Powell
openaire   +3 more sources

Hyperactivity as a Lethal Factor in Fish

Journal of the Fisheries Research Board of Canada, 1958
Death occurs in fishes under certain circumstances following severe muscular activity. The precise cause of death is not yet known. However, it is possible that the severe disturbance to acid-base relationships following the large increase of lactic acid liberated from muscle glycogen may be the principal cause of death.
Edgar C. Black
openaire   +2 more sources

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Inhibitors of anthrax lethal factor

Bioorganic & Medicinal Chemistry Letters, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Brandon D, Gaddis, Larisa V, Avramova, Jean, Chmielewski   +2 more
openaire   +2 more sources