Screening inhibitors of anthrax lethal factor [PDF]
Nature, 2002 The disease anthrax is caused by lethal factor, an enzyme component of the toxin produced by the spore-forming bacterium Bacillus anthracis. Here we describe substrate molecules for this factor that offer a means for high-throughput screening of potential inhibitors for use in anthrax treatment.
TONELLO, FIORELLA +4 more
openaire +6 more sources
CD4+ T cells targeting dominant and cryptic epitopes from Bacillus anthracis Lethal Factor [PDF]
Frontiers in Microbiology, 2016 Anthrax is an endemic infection in many countries, particularly in the developing world. The causative agent, Bacillus anthracis, mediates disease through the secretion of binary exotoxins.
Stephanie eAscough +11 more
doaj +2 more sources
Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome. [PDF]
PLoS Pathogens, 2012 NOD-like receptor (NLR) proteins (Nlrps) are cytosolic sensors responsible for detection of pathogen and danger-associated molecular patterns through unknown mechanisms.
Jonathan L Levinsohn +8 more
doaj +2 more sources
Lethal Factor and Anti-Protective Antigen IgG Levels Associated with Inhalation Anthrax, Minnesota, USA [PDF]
Emerging Infectious Diseases, 2014 Bacillus anthracis was identified in a 61-year-old man hospitalized in Minnesota, USA. Cooperation between the hospital and the state health agency enhanced prompt identification of the pathogen.
Mark D. Sprenkle +9 more
doaj +2 more sources
An immune-adrenergic pathway induces lethal levels of platelet-activating factor in mice [PDF]
Communications BiologyAcute immune responses with excess production of cytokines, lipid/chemical mediators, or coagulation factors, often result in lethal damage. In addition, the innate immune system utilizes multiple types of receptors that recognize neurotransmitters as ...
Shuto Tanaka +14 more
doaj +3 more sources
Prospects for the use of Bacillus anthracis toxin in cancer therapy
Ветеринария сегодня, 2022 Cancer is one of the major causes of death in pet animals and humans worldwide. The contraindications and side effects associated with conventional cancer therapies heighten the importance of research aimed at finding new ways to combat cancer.
A. P. Rodionov +3 more
doaj +1 more source
Anthrax Toxin Detection: From In Vivo Studies to Diagnostic Applications
Microorganisms, 2020 Anthrax toxins are produced by Bacillus anthracis throughout infection and shape the physiopathogenesis of the disease. They are produced in low quantities but are highly efficient.
Jean-Nicolas Tournier +1 more
doaj +1 more source
Anthrax lethal factor inhibition [PDF]
Proceedings of the National Academy of Sciences, 2005 The primary virulence factor of Bacillus anthracis is a secreted zinc-dependent metalloprotease toxin known as lethal factor (LF) that is lethal to the host through disruption of signaling pathways, cell destruction, and circulatory shock. Inhibition of this proteolytic-based LF toxemia could
W L, Shoop +23 more
openaire +2 more sources
Pathogens, 2020 : Prompt and accurate detection of Bacillus anthracis spores is crucial in the event of intentional spore dissemination in order to reduce the number of expected casualties.
Efi Makdasi +5 more
doaj +1 more source
Antidotes to anthrax lethal factor intoxication. Part 1: Discovery of potent lethal factor inhibitors with in vivo efficacy [PDF]
Bioorganic and Medicinal Chemistry Letters, 2010 Stephen Leppla, Mahtab Moayeri
exaly +2 more sources