Results 41 to 50 of about 3,844,636 (291)
Two Genetically Defined Tram-Acting Loci Coordinately Regulate Overlapping Sets of Liver-Specific Genes [PDF]
, 1990 Mice homozygous for deletions around the albino locus fail to activate expression of a set of neonatal liver functions and die shortly after birth. This phenotype is thought to result from the loss of a positive trans-acting factor, denoted alf, in ...
Boshart, Michael +5 more
core +1 more source
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2021 Introduction: Anthrax is a zoonotic disease and vaccine production is one way to protect people against this bacterium. This study investigates the application of copolymer nanocapsule (PEG-PLA) systems with controlled release specificity for a ...
Hossein Honari +3 more
doaj
Anthrax lethal factor cleaves mouse nlrp1b in both toxin-sensitive and toxin-resistant macrophages. [PDF]
PLoS ONE, 2012 Anthrax lethal factor (LF) is the protease component of anthrax lethal toxin (LT). LT induces pyroptosis in macrophages of certain inbred mouse and rat strains, while macrophages from other inbred strains are resistant to the toxin.
Kristina A Hellmich +8 more
doaj +1 more source
Capturing the transcription factor interactome in response to sub-lethal insecticide exposure
Current Research in Insect Science, 2021 The increasing levels of pesticide resistance in agricultural pests and disease vectors represents a threat to both food security and global health. As insecticide resistance intensity strengthens and spreads, the likelihood of a pest encountering a sub ...
Victoria A Ingham +3 more
doaj +1 more source
The Relationship Between a Person's Criminal History, Immediate Situational Factors, and Lethal Versus Non-Lethal Events [PDF]
, 2015 When investigating serious violence, studies tend to look primarily at offenders and their background. This study investigates the influence of offenders' and victims' criminal history and immediate situational factors on the likelihood that violent ...
Nieuwbeerta, P. +7 more
core +2 more sources
Participation of endogenous tumour necrosis factor α in host resistance to cytomegalovirus infection [PDF]
, 1993 Interferon gamma (IFN) represents an essential cytokine involved in murine cytomegalovirus (MCMV) clearance from the salivary gland and the control of horizontal transmission.
Crnkovic, Irena +5 more
core +1 more source
Role of N-terminal amino acids in the potency of anthrax lethal factor. [PDF]
PLoS ONE, 2008 Anthrax lethal factor (LF) is a Zn(+2)-dependent metalloprotease that cleaves several MAPK kinases and is responsible for the lethality of anthrax lethal toxin (LT). We observed that a recombinant LF (LF-HMA) which differs from wild type LF (LF-A) by the
Pradeep K Gupta +4 more
doaj +1 more source
Biosensors, 2021 Anthrax lethal factor (LF) is one of the enzymatic components of the anthrax toxin responsible for the pathogenic responses of the anthrax disease. The ability to screen multiplexed ligands against LF and subsequently estimate the effective kinetic rates
Allison M. Marn +3 more
doaj +1 more source
Toxins, 2012 Anthrax Lethal Toxin consists of Protective Antigen (PA) and Lethal Factor (LF), and current vaccination strategies focus on eliciting antibodies to PA. In human vaccination, the response to PA can vary greatly, and the response is often directed toward ...
Judith A. James +8 more
doaj +1 more source
Anthrax Lethal Toxin and the Induction of CD4 T Cell Immunity
Toxins, 2012 Bacillus anthracis secretes exotoxins which act through several mechanisms including those that can subvert adaptive immunity with respect both to antigen presenting cell and T cell function.
Daniel M. Altmann +2 more
doaj +1 more source