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Anthrax Lethal Factor Investigated by Molecular Simulations
Journal of Chemical Theory and Computation, 2008The anthrax disease is caused by the lethal toxin secreted by the bacterium Bacillus anthracis. The toxin is a protein aggregate which contains a Zn-based hydrolase called anthrax Lethal Factor (LF). In this work, we investigate the structure of its Michaelis complex with an optimized MAPKK-like substrate using several computational methods including ...
Hong, R., Magistrato, A., Carloni, P.
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An enzymatic electrochemiluminescence assay for the lethal factor of anthrax
Analytical Biochemistry, 2003The lethal factor (LF) of anthrax toxin is the toxic component of the exotoxin (lethal toxin) secreted by toxic strains of Bacillus anthracis. The lethal factor is a zinc-dependent metalloprotease that specifically cleaves the mitogen-activated protein kinase kinase (MAPKK) family of enzymes.
Victor R, Rivera +3 more
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LETHAL FACTORS IN BILE PERITONITIS
Archives of Surgery, 1936The mechanism of death in bile peritonitis has puzzled investigators for a number of years. Although the condition is rare clinically, its theoretical implications warrant a thorough consideration. In the present paper certain findings are reported that indicate that one of the lethal factors in bile peritonitis is a disturbance of fluid balance in the
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Substrate specificity of the anthrax lethal factor
Doklady Biochemistry and Biophysics, 2008M Yu, Zakharova +5 more
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Capillary Emboli as a Lethal Factor in Burns
Science, 1942H, Kabat, M, Levine
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The Lethal Phenotype of Cancer: The Molecular Basis of Death Due to Malignancy
Ca-A Cancer Journal for Clinicians, 2007Sunita Shankar +2 more
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