Results 11 to 20 of about 316,000 (254)

Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome. [PDF]

PLoS Pathogens, 2012
NOD-like receptor (NLR) proteins (Nlrps) are cytosolic sensors responsible for detection of pathogen and danger-associated molecular patterns through unknown mechanisms.
Jonathan L Levinsohn, Zachary L Newman, Kristina A Hellmich, Rasem Fattah, Matthew A Getz, Shihui Liu, Inka Sastalla, Stephen H Leppla, Mahtab Moayeri   +8 more
doaj   +2 more sources

Lethal Factor and Anti-Protective Antigen IgG Levels Associated with Inhalation Anthrax, Minnesota, USA [PDF]

Emerging Infectious Diseases, 2014
Bacillus anthracis was identified in a 61-year-old man hospitalized in Minnesota, USA. Cooperation between the hospital and the state health agency enhanced prompt identification of the pathogen.
Mark D. Sprenkle, Jayne Griffith, William Marinelli, Anne E. Boyer, Conrad P. Quinn, Nicki T. Pesik, Alex Hoffmaster, Joseph Keenan, Billie A. Juni, David D. Blaney   +9 more
doaj   +2 more sources

Chimeric Antibody Engineering Against Bacillus anthracis Lethal Toxin: Neutralization Efficacy and Mechanism of Action [PDF]

Toxins
Bacillus anthracis has three main virulence factors: an extracellular capsule and two binary toxins (lethal toxin—consists of a lethal factor and a protective antigen, and edema toxin—consists of an edema factor and a protective antigen).
Olga V. Kalmantaeva, Maksim A. Marin, Anastasia A. Ershova, Alena K. Ryabko, Yana O. Romanenko, Tatyana I. Kombarova, Ivan A. Dyatlov, Victoria V. Firstova   +7 more
doaj   +2 more sources

Prospects for the use of Bacillus anthracis toxin in cancer therapy

Ветеринария сегодня, 2022
Cancer is one of the major causes of death in pet animals and humans worldwide. The contraindications and side effects associated with conventional cancer therapies heighten the importance of research aimed at finding new ways to combat cancer.
A. P. Rodionov, S. V. Ivanova, E. A. Artemeva, L. A. Melnikova   +3 more
doaj   +1 more source

Anthrax Toxin Detection: From In Vivo Studies to Diagnostic Applications

Microorganisms, 2020
Anthrax toxins are produced by Bacillus anthracis throughout infection and shape the physiopathogenesis of the disease. They are produced in low quantities but are highly efficient.
Jean-Nicolas Tournier, Clémence Rougeaux   +1 more
doaj   +1 more source

Anthrax lethal factor inhibition [PDF]

Proceedings of the National Academy of Sciences, 2005
The primary virulence factor of Bacillus anthracis is a secreted zinc-dependent metalloprotease toxin known as lethal factor (LF) that is lethal to the host through disruption of signaling pathways, cell destruction, and circulatory shock. Inhibition of this proteolytic-based LF toxemia could
W L, Shoop, Y, Xiong, J, Wiltsie, A, Woods, J, Guo, J V, Pivnichny, T, Felcetto, B F, Michael, A, Bansal, R T, Cummings, B R, Cunningham, A M, Friedlander, C M, Douglas, S B, Patel, D, Wisniewski, G, Scapin, S P, Salowe, D M, Zaller, K T, Chapman, E M, Scolnick, D M, Schmatz, K, Bartizal, M, MacCoss, J D, Hermes   +23 more
openaire   +2 more sources

Rapid and Sensitive Multiplex Assay for the Detection of B. anthracis Spores from Environmental Samples

Pathogens, 2020
: Prompt and accurate detection of Bacillus anthracis spores is crucial in the event of intentional spore dissemination in order to reduce the number of expected casualties.
Efi Makdasi, Orly Laskar, Itai Glinert, Ron Alcalay, Adva Mechaly, Haim Levy   +5 more
doaj   +1 more source

Antidotes to anthrax lethal factor intoxication. Part 1: Discovery of potent lethal factor inhibitors with in vivo efficacy [PDF]

Bioorganic and Medicinal Chemistry Letters, 2010
Stephen Leppla, Mahtab Moayeri
exaly   +2 more sources

Current understanding of Bacillus anthracis toxin molecules organization and approaches for blocking their cytotoxic action

Инфекция и иммунитет, 2020
Here, we review the data on mechanisms inhibiting cytotoxic effect of anthrax toxin on the immune system cells. Various disease forms, immunopathogenesis and contemporary methods for anthrax treatment are discussed.
V. V. Firstova, I. G. Shemyakin, I. A. Dyatlov   +2 more
doaj   +1 more source

The Power of Genomic in situ Hybridization (GISH) in Interspecific Breeding of Bulb Onion (Allium cepa L.) Resistant to Downy Mildew (Peronospora destructor [Berk.] Casp.)

Plants, 2019
We exploited the advantages of genomic in situ hybridization (GISH) to monitor the introgression process at the chromosome level using a simple and robust molecular marker in the interspecific breeding of bulb onion (Allium cepa L.) that is resistant to ...
Ludmila Khrustaleva, Majd Mardini, Natalia Kudryavtseva, Rada Alizhanova, Dmitry Romanov, Pavel Sokolov, Grigory Monakhos   +6 more
doaj   +1 more source