Results 221 to 230 of about 94,541 (354)

Development and Application of Organic Sonosensitizers in Cancer Therapy

Aggregate, EarlyView.
This review provides a comprehensive overview of organic sonosensitizers employed in cancer treatment, describing their underlying mechanisms and structure‐activity relationship in terms of sonodynamic therapy. The significance of nanotechnology and combination therapy with other oncological modalities (photothermal therapy, photodynamic therapy, etc.)
Yuhan Ding, Yuchen Yang, Omer Aras, Feifei An, Mengjiao Zhou, Yichao Chai   +5 more
wiley   +1 more source

Protection against Anthrax Lethal Toxin Challenge by Genetic Immunization with a Plasmid Encoding the Lethal Factor Protein

, 2001
Brian M. Price, Adriane L. Liner, Sukjoon Park, Stephen H. Leppla, Alfred Mateczun, Darrell R. Galloway   +5 more
openalex   +1 more source

Dachshund Homolog 1: Unveiling Its Potential Role in Megakaryopoiesis and Bacillus anthracis Lethal Toxin-Induced Thrombocytopenia. [PDF]

Int J Mol Sci
Lin GL, Chang HH, Lin WT, Liou YS, Lai YL, Hsieh MH, Chen PK, Liao CY, Tsai CC, Wang TF, Chu SC, Kau JH, Huang HH, Hsu HL, Sun DS.   +14 more
europepmc   +1 more source

Multifunctional Framework Nucleic Acid Vehicle for Antibiotic Sensitization and Treatment of Methicillin‐Resistant Staphylococcus aureus

Aggregate, EarlyView.
A self‐assembling, aggregation‐enhanced tetrahedral DNA nanostructure (tFNA), termed TACs, enables localized accumulation and sustained release of ceftriaxone while co‐delivering antisense oligonucleotides that silence mecA, reduce PBP2a expression, and restore β‐lactam susceptibility in MRSA.
Yicheng Zhao, Jingyi Si, Shisong Jing, Bingmei Wang, Yueshan Xu, Jiyu Guan, Quan Liu, Jianlei Shen, Min Lv, Li Wang, Changfeng Zhu   +10 more
wiley   +1 more source

Macrophage-Derived Cell Lines Do Not Express Proinflammatory Cytokines after Exposure to Bacillus anthracis Lethal Toxin

, 2001
James L. Erwin, Luis M. DaSilva, Sina Bavari, Stephen F. Little, Arthur M. Friedlander, Tran C. Chanh   +5 more
openalex   +1 more source

Blocking anthrax lethal toxin at the protective antigen channel by using structure-inspired drug design [PDF]

, 2005
Vladimir A. Karginov, Ekaterina M. Nestorovich, Mahtab Moayeri, Stephen H. Leppla, Sergey M. Bezrukov   +4 more
openalex   +1 more source

Saarvienin A—A Novel Glycopeptide with Potent Activity against Drug‐Resistant Bacteria

Angewandte Chemie, EarlyView.
A structurally distinct glycopeptide, saarvienin A, represents a new family of glycopeptide antibiotics consisting of five sugar/aminosugar units connected to a halogenated peptide core. Saarvienin A overcomes vancomycin resistance and shows strong activity against drug‐resistant Gram‐positive bacteria, in particular, high‐priority pathogens such as ...
Amninder Kaur, Jaime Felipe Guerrero‐Garzón, Sari Rasheed, Martin Zehl, Franziska Fries, Bernd Morgenstern, Sergey B. Zotchev, Rolf Müller   +7 more
wiley   +2 more sources

Anthrax lethal toxin and tumor necrosis factor-α synergize on intestinal epithelia to induce mouse death. [PDF]

Protein Cell
Gao X, Teng T, Liu Y, Ai T, Zhao R, Fu Y, Zhang P, Han J, Zhang Y.   +8 more
europepmc   +1 more source

Intradermal immunization with botulinum neurotoxin serotype E DNA vaccine induces humoral and cellular immunity and protects against lethal toxin challenge. [PDF]

Hum Vaccin Immunother, 2019
Kim NY, Ahn HB, Yu CH, Song DH, Hur GH, Shin YK, Shin S.   +6 more
europepmc   +1 more source

Hierarchical Superposition Framework Reveals the Complex Effects of Natural Medicine Formulas

Advanced Intelligent Systems, EarlyView.
A novel hierarchical superposition pharmacological model incorporates the principle of hierarchical structures from physics to simulate the spatiotemporal dynamics of drug combinations, to elucidate the universal law underlying drug combination effects. By modeling cross‐level causal transmission and attenuation, it advances beyond traditional additive
Weifeng Liang, Dingsi Xiang, Shengli Mi, Jiajun Huang   +3 more
wiley   +1 more source