Results 241 to 250 of about 67,942 (278)

Hydrogel‐based drug delivery systems for intracerebral hemorrhage with therapeutic advances and emerging roles of the bone–brain axis

Interdisciplinary Medicine, EarlyView.
Hydrogel‐based drug delivery systems offer a promising approach for treating intracerebral hemorrhage (ICH) by overcoming blood‐brain barrier limitations, enabling precise, sustained release of neuroprotective and anti‐inflammatory agents. These systems enhance treatment efficacy, but challenges remain in biosafety, drug penetration, and scalability ...
Haojun Shi, Min Chen, Yisheng Chen, MengYao Li, Jiale Ma, Zuozhen Yin, Li Wu, YangBao Miao, Zemin Ou, Ke Wu, Zhijie Xu, Lizhi Li, Shaocong Zhao, Shiwei He, Bin Huang, Guanwen He, Guanghui Wu, John H. Zhang, Liang Shi   +18 more
wiley   +1 more source

Differential Thermal Inactivation Enables Simultaneous Quantitation of Ricin and Abrin. [PDF]

Toxins (Basel)
Jeong WH.
europepmc   +1 more source

Dissecting conserved molecular mechanisms of biological toxin activity through CRISPR screening. [PDF]

Biochem Soc Trans
Waller MA, D'Araujo TY, Denes CE, Neely GG.   +3 more
europepmc   +1 more source

Adeno-associated virus delivery of anti-alpha toxin monoclonal antibodies confers protection against Staphylococcus aureus infections. [PDF]

PLoS Pathog
Hommes JW, Hughes ME, Cheung D, Petri B, Orthner LM, van der Linden TJ, Bardoel BW, Deo SK, Patel DT, Flannagan RS, Heinrichs DE, Wootton SK, Surewaard BGJ.   +12 more
europepmc   +1 more source

[Thermolabile lethal toxin of pathogenic staphylococci].

Zhurnal mikrobiologii, epidemiologii i immunobiologii, 1972
openaire   +1 more source

Purification of a Lethal Toxin of Edwardsiella tarda

Purification of a Lethal Toxin of Edwardsiella tarda
openaire  

Anthrax toxin: a tripartite lethal combination.

FEBS letters, 2002
Anthrax is a severe bacterial infection that occurs when Bacillus anthracis spores gain access into the body and germinate in macrophages, causing septicemia and toxemia. Anthrax toxin is a binary A-B toxin composed of protective antigen (PA), lethal factor (LF), and edema factor (EF).
ASCENZI P, VISCA P, IPPOLITO G, SPALLAROSSA, ANDREA, BOLOGNESI M, MONTECUCCO C.   +5 more
openaire   +6 more sources

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β-Cyclodextrin derivatives that inhibit anthrax lethal toxin

Bioorganic and Medicinal Chemistry, 2006
Recently, we demonstrated that simultaneous blocking of bacterial growth by antibiotics and inhibition of anthrax toxin action with antibodies against protective antigen were beneficial for the treatment of anthrax. The present study examined the hypothesis that blocking the pore formed by protective antigen can inhibit the action of anthrax toxin. The
Vladimir A Karginov, Nour Eddine Fahmi, Sidney M Hecht   +2 more
exaly   +3 more sources

The Effect of Lethal Toxin on the Respiratory Epithelium. [PDF]

, 2008
Inhalational anthrax is an acute infectious disease caused by exposure of the lungs to B. anthracis spores. Alveolar macrophages engulf spores causing them to germinate to the vegetative form of B. anthracis, which secretes edema toxin (ET)and lethal toxin (LT). The pathogenesis of inhalational anthrax is characterized by flu-like symptoms, respiratory
Lehmann, Mandy
openaire   +2 more sources

Proteome analysis of mouse macrophages treated with anthrax lethal toxin

Biochimica Et Biophysica Acta - Proteins and Proteomics, 2005
Anthrax toxin produced by bacillus anthracis is a tripartite toxin comprising of protective antigen (PA), lethal factor (LF) and edema factor (EF). PA is the receptor-binding component, which facilitates the entry of LF or EF into the cytosol.
Pradeep K Gupta, Kirti Sharma, Abid R Mattoo   +2 more
exaly   +2 more sources