Results 221 to 230 of about 988,812 (316)

<i>Bacillus cereus</i> enterotoxins change epithelial barrier function and ion transport in a Caco-2/HT29-MTX co-culture model, provoking inflammation, apoptosis and membrane damage. [PDF]

Virulence
Albahri M, Seeger B, Beineke A, Esatbeyoglu T, Plötz M, Jessberger N.   +5 more
europepmc   +1 more source

Magnetoreceptor Promotes Hepatocellular Carcinoma Development and Blunts Sorafenib‐Induced Ferroptosis by Regulating Iron Homeostasis

Advanced Science, EarlyView.
Magnetoreceptor (MagR) regulates iron homeostasis and mitochondrial function in hepatocellular carcinoma (HCC) cells. Specifically, MagR deficiency suppresses tumor cell proliferation, migration, and invasion and enhances sorafenib‐induced ferroptosis through iron accumulation.
Tao Wang, Chenghua Song, Xin He, Mengzhou Wang, Wuming Liu, Xiaolin Wang, Yuanyuan Zhang, Jia Zhang, Lin Zhang, Dan Li, Yu Zhang, Zheng Wu, Yi Lyu, Rongqian Wu   +13 more
wiley   +1 more source

Digoxin Alleviates Osteoarthritis by Inhibiting Macrophage Extracellular Trap Formation via Disruption of the LSP1‐SOD1 Interaction

Advanced Science, EarlyView.
Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan, Xinzhe Feng, Chuanju Liu, Jianfei Tong, Zhi Li, Chenxu Liu, Yutong Dong, Chen Meng, Yihong Xu, Weidong Xu   +9 more
wiley   +1 more source

Correction: Ultrapotent neutralization of Bacillus anthracis toxin by a human antibody via blockade of PA oligomerization. [PDF]

PLoS Pathog
Wang Q, Fang T, Song Z, Huang X, He S, Li T, Li J, Chi X, Fan P, Yu C.   +9 more
europepmc   +1 more source

Ultrafast Micrometric Laser Structuring of Polymer Surfaces for Highly Organized Skeletal Muscle Tissue Modeling

Advanced Science, EarlyView.
Standard cell culture supports were functionalized by laser‐structuring to generate advanced topographies tailored to skeletal muscle tissue. The physicochemical modifications of the polymeric surfaces and their interactions with cells were thoroughly investigated, confirming both safety and effectiveness in guiding muscle cell organization.
Lucas Duvert, Lorena Garcia‐Castillo, Clarissa Murru, Adrien Casanova, Daniel Ferry, Pierre Perrin, Solene Coste, Anne Bigot, Anne‐Patricia Alloncle, Frederique Magdinier, Stefano Testa   +10 more
wiley   +1 more source

Proteomic characterization of <i>Tityus championi</i> venom and recombinant expression of its major neurotoxin. [PDF]

J Venom Anim Toxins Incl Trop Dis
Muñoz-Agames MDC, Salazar MH, Clement H, Hernández-Orihuela L, Hernández-Ortiz M, Encarnación-Guevara S, Cleghorn J, Acosta H, Corzo G.   +8 more
europepmc   +1 more source

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

Advanced Science, EarlyView.
A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao, Jianzhong Cao, Wenyue Liu, Xuyun Li, Haolin Zhang, Xiaofang Zhang, Shiyang Shi, Huilong Yin, Junjie Li, Angang Yang, Rui Zhang   +10 more
wiley   +1 more source

Structure-Activity Relationship for Inflammasome Inhibition by Thiomuscimol. [PDF]

Int J Mol Sci
Anderson MJ, Loomis WP, den Hartigh AB, Frølund B, Fink SL.   +4 more
europepmc   +1 more source

Correlation between anthrax lethal toxin neutralizing antibody levels and survival in guinea pigs and nonhuman primates vaccinated with the AV7909 anthrax vaccine candidate. [PDF]

Vaccine, 2017
Savransky V, Shearer JD, Gainey MR, Sanford DC, Sivko GS, Stark GV, Li N, Ionin B, Lacy MJ, Skiadopoulos MH.   +9 more
europepmc   +1 more source

Anthrax Lethal Toxin Triggers the Formation of a Membrane-Associated Inflammasome Complex in Murine Macrophages

Infection and Immunity, 2009
Adel M. Nour, Yee-Gui-De Yeung, L. Santambrogio, Eric D. Boyden, E. Stanley, J. Brojatsch   +5 more
semanticscholar   +1 more source