Results 301 to 310 of about 120,091 (334)

BPTES inhibits anthrax lethal toxin-induced inflammatory response

International Immunopharmacology, 2020
Bacillus anthracis is a lethal agent of anthrax disease and the toxins are required in anthrax pathogenesis. The anthrax lethal toxin can trigger NLRP1b inflammasome activation and pyroptosis. Although the underlying mechanism is well understood, the medications targeting the NLRP1b inflammasome are not available in the clinic. Herein, we describe that
Wang, Jinling, Yang, Daowei, Shen, Xizi, Wang, Junsheng, Liu, Xiaomei, Lin, Jinzhou, Zhong, Jiaying, Zhao, Yilin, Qi, Zhongquan   +8 more
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Anthrax lethal toxin (Bacillus anthracis)

1997
Abstract Anthrax lethal toxin (LeTx) induces shock and sudden death in test animals, mimicking the symptoms of systemic anthrax infections (eppla 1991; Hanna et al. 1993). Bacterial strains lacking either of the two LeTx components are highly attenuated, and immunization against the toxin protects animals from 8.
P C Hanna, R J Collier
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Validation of the anthrax lethal toxin neutralization assay

Biologicals, 2004
A validation of the performance characteristics of a toxin neutralization assay is presented. This in vitro assay measures the functional ability of antisera, containing antibodies to anthrax lethal toxin, to specifically protect J774A.1 cells against Bacillus anthracis lethal toxin cytotoxicity.
Donna, Hering, William, Thompson, John, Hewetson, Stephen, Little, Sarah, Norris, Judith, Pace-Templeton   +5 more
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Anthrax toxin: a tripartite lethal combination.

FEBS letters, 2002
Anthrax is a severe bacterial infection that occurs when Bacillus anthracis spores gain access into the body and germinate in macrophages, causing septicemia and toxemia. Anthrax toxin is a binary A-B toxin composed of protective antigen (PA), lethal factor (LF), and edema factor (EF).
ASCENZI P, VISCA P, IPPOLITO G, SPALLAROSSA, ANDREA, BOLOGNESI M, MONTECUCCO C.   +5 more
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β-Cyclodextrin derivatives that inhibit anthrax lethal toxin

Bioorganic & Medicinal Chemistry, 2006
Recently, we demonstrated that simultaneous blocking of bacterial growth by antibiotics and inhibition of anthrax toxin action with antibodies against protective antigen were beneficial for the treatment of anthrax. The present study examined the hypothesis that blocking the pore formed by protective antigen can inhibit the action of anthrax toxin. The
Vladimir A, Karginov, Adiamseged, Yohannes, Tanisha M, Robinson, Nour Eddine, Fahmi, Kenneth, Alibek, Sidney M, Hecht   +5 more
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Anthrax lethal toxin: a weapon of multisystem destruction

Cellular and Molecular Life Sciences, 2004
Lethal toxin (LT) is a major virulence factor secreted by anthrax bacteria. It is composed of two proteins, PA (protective antigen) and LF (lethal factor). PA transports the LF inside the cell, where LF, a zinc-dependent metalloprotease cleaves the mitogen activated protein kinase kinase (MAPKK) enzymes of the mitogen activated protein kinase (MAPK ...
A, Agrawal, B, Pulendran
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Antibodies Against Recombinant Catalytic Domain of Lethal Toxin of Clostridium sordellii Neutralize Lethal Toxin Toxicity in HeLa Cells

Protein and Peptide Letters, 2012
Lethal toxin of Clostridium sordellii (MLD 150 ng/kg) is one of the most potent Clostridial toxins and is responsible for most of the diseases including sudden death syndrome in cattle, sheep and toxic shock syndrome, necrotizing faciitis, neonatal omphalitis and gangrene in humans. Lethal toxin (TcsL) is a single chain protein of about 270 kDa. In the
Preetika, Arya, S, Ponmariappan, Lokendra, Singh, G B K S, Prasad   +3 more
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Crystallographic studies of the anthrax lethal toxin

Journal of Applied Microbiology, 1999
Anthrax lethal toxin comprises two proteins: protective antigen (PA; MW 83 kDa) and lethal factor (LF; MW 87 kDa). We have recently determined the crystal structure of the 735-residue PA in its monomeric and heptameric forms (Petosa et al. 1997). It bears no resemblance to other bacterial toxins of known three-dimensional structure, and defines a new ...
, Liddington, , Pannifer, , Hanna, , Leppla, , Collier   +4 more
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Novel Functions of Anthrax Lethal Toxin

2009
Bacillus anthracis is a gram positive spore-forming bacterium that can cause cutaneous, gastrointestinal or inhalational anthrax in many animals and humans. Vegetative B. anthracis generates two essential virulence factors: the anthrax lethal toxin and the poly-γ-D glutamic acid capsule.
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Proteomics study of anthrax lethal toxin‐treated murine macrophages

ELECTROPHORESIS, 2006
AbstractThe anthrax lethal toxin (LeTx) is composed of two proteins, protective antigen and lethal factor, which bind and enter the cell through a host receptor termed the anthrax toxin receptor (ATR). In the cell, LeTx targets p38, part of the MAP kinase signaling pathway.
Jeffrey F, Kuhn, Patric, Hoerth, Silvia T, Hoehn, Tobias, Preckel, Kenneth B, Tomer   +4 more
openaire   +2 more sources