Results 281 to 290 of about 988,812 (316)
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The Pathogenesis of the Lethal Effect of Anthrax Toxin in the Rat
Journal of Infectious Diseases, 1966ditions previously described (Beall et al, 1962). After 24 hours growth the bulk of the bacteria was removed by centrifugation, and the crude or unfractionated toxin used in these experiments was prepared in 1 of 2 ways: (a) the culture was sterilized by filtration through Millipore filters in stainless steel funnels, frozen, and stored at ?20 C; or (b)
F A, Beall, F G, Dalldorf
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Molecular Microbiology, 1994
SummaryComparison of the anthrax toxin lethal factor (LF) amino acid sequence with sequences in the Swiss protein database revealed short regions of similarity with the consensus zinc‐binding site, HEXXH, that is characteristic of metalloproteases. Several protease inhibitors, including bestatin and captopril, prevented intoxication of macrophages by ...
K R, Klimpel, N, Arora, S H, Leppla
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SummaryComparison of the anthrax toxin lethal factor (LF) amino acid sequence with sequences in the Swiss protein database revealed short regions of similarity with the consensus zinc‐binding site, HEXXH, that is characteristic of metalloproteases. Several protease inhibitors, including bestatin and captopril, prevented intoxication of macrophages by ...
K R, Klimpel, N, Arora, S H, Leppla
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Crystallographic studies of the anthrax lethal toxin
Journal of Applied Microbiology, 1999Anthrax lethal toxin comprises two proteins: protective antigen (PA; MW 83 kDa) and lethal factor (LF; MW 87 kDa). We have recently determined the crystal structure of the 735-residue PA in its monomeric and heptameric forms (Petosa et al. 1997). It bears no resemblance to other bacterial toxins of known three-dimensional structure, and defines a new ...
, Liddington +4 more
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Protein and Peptide Letters, 2012
Lethal toxin of Clostridium sordellii (MLD 150 ng/kg) is one of the most potent Clostridial toxins and is responsible for most of the diseases including sudden death syndrome in cattle, sheep and toxic shock syndrome, necrotizing faciitis, neonatal omphalitis and gangrene in humans. Lethal toxin (TcsL) is a single chain protein of about 270 kDa. In the
Preetika, Arya +3 more
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Lethal toxin of Clostridium sordellii (MLD 150 ng/kg) is one of the most potent Clostridial toxins and is responsible for most of the diseases including sudden death syndrome in cattle, sheep and toxic shock syndrome, necrotizing faciitis, neonatal omphalitis and gangrene in humans. Lethal toxin (TcsL) is a single chain protein of about 270 kDa. In the
Preetika, Arya +3 more
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Anthrax lethal toxin (Bacillus anthracis)
1997Abstract Anthrax lethal toxin (LeTx) induces shock and sudden death in test animals, mimicking the symptoms of systemic anthrax infections (eppla 1991; Hanna et al. 1993). Bacterial strains lacking either of the two LeTx components are highly attenuated, and immunization against the toxin protects animals from 8.
P C Hanna, R J Collier
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Isolation of the major lethal toxin in the venom of Bungarus flaviceps
Toxicon, 2002The major lethal toxin in the venom of Bungarus flaviceps has been isolated by ion-exchange chromatography, absorption chromatography and RP-HPLC with a 14-fold purification and an overall yield of 16.5% of the lethal toxicity contained in crude venom. Its sublethal dose (LD(50)) determined in mice weighing 18-20 g was 0.25 (0.19-0.32) microg per mouse.
O, Khow +3 more
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Novel Repression of the Glucocorticoid Receptor by Anthrax Lethal Toxin
Annals of the New York Academy of Sciences, 2004Abstract: Death from anthrax has been reported to occur from systemic shock. The lethal toxin (LeTx) is the major effector of anthrax mortality. Although the mechanism of entry of this toxin into cells is well understood, its actions once inside the cell are not as well understood. LeTx is known to cleave and inactivate MAPKKs.
Jeanette I, Webster +2 more
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Binding and cell intoxication studies of anthrax lethal toxin
Molecular Biology Reports, 2012Anthrax lethal toxin (LT) is a major virulence factor of Bacillus anthracis. The vast majority of the anthrax toxin-related literature describes the assembly of LT as a cell-dependent process. However, some reports have provided evidence for the existence of a fully assembled LT, either in vitro or in the bloodstream of anthrax-infected animals.
Momchilo, Vuyisich +2 more
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Novel Functions of Anthrax Lethal Toxin
2009Bacillus anthracis is a gram positive spore-forming bacterium that can cause cutaneous, gastrointestinal or inhalational anthrax in many animals and humans. Vegetative B. anthracis generates two essential virulence factors: the anthrax lethal toxin and the poly-γ-D glutamic acid capsule.
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The Effect of Lethal Toxin on the Respiratory Epithelium.
2008Inhalational anthrax is an acute infectious disease caused by exposure of the lungs to B. anthracis spores. Alveolar macrophages engulf spores causing them to germinate to the vegetative form of B. anthracis, which secretes edema toxin (ET)and lethal toxin (LT). The pathogenesis of inhalational anthrax is characterized by flu-like symptoms, respiratory
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