Results 271 to 280 of about 988,812 (316)

BPTES inhibits anthrax lethal toxin-induced inflammatory response.

open access: yesInternational Immunopharmacology, 2020
Bacillus anthracis is a lethal agent of anthrax disease and the toxins are required in anthrax pathogenesis. The anthrax lethal toxin can trigger NLRP1b inflammasome activation and pyroptosis.
Jinling Wang   +8 more
semanticscholar   +2 more sources

Lethal toxin of Clostridium sordellii is associated with fatal equine atypical myopathy.

open access: yesVeterinary Microbiology, 2010
The lethal toxin of Clostridium sordellii (TcsL) evokes severe, mostly fatal disease patterns like toxic shock syndrome in humans and animals. Since this large clostridial toxin-induced severe muscle damaging when injected intramuscularly into mice, we ...
Lucia Unger-Torroledo   +8 more
semanticscholar   +2 more sources

Identification and characterization of the key lethal toxin from jellyfish Cyanea nozakii.

International Journal of Biological Macromolecules, 2023
Jellyfish Cyanea nozakii venom is a complex mixture of various toxins, most of which are proteinous biological macromolecules and are considered to be responsible for clinical symptoms or even death after a severe sting.
Rong-Feng Li   +4 more
semanticscholar   +1 more source

Anthrax lethal and edema toxins in anthrax pathogenesis [PDF]

open access: yesTrends in Microbiology, 2014
The pathophysiological effects resulting from many bacterial diseases are caused by exotoxins released by the bacteria. Bacillus anthracis, a spore-forming bacterium, is such a pathogen, causing anthrax through a combination of bacterial infection and toxemia. B.
Stephen H. Leppla   +2 more
exaly   +3 more sources

Validation of the anthrax lethal toxin neutralization assay

Biologicals, 2004
A validation of the performance characteristics of a toxin neutralization assay is presented. This in vitro assay measures the functional ability of antisera, containing antibodies to anthrax lethal toxin, to specifically protect J774A.1 cells against Bacillus anthracis lethal toxin cytotoxicity.
Donna, Hering   +5 more
openaire   +2 more sources

Disulfide Bonds of Purothionin, a Lethal Toxin for Yeasts

The Journal of Biochemistry, 1978
Purothionin isolated from commercial wheat flour contained several components and two of them (A-I and A-II) were isolated in pure form by CM-52 column chromatography. Each component contained 45 amino acid residues with a 4 disulfide bonds. Purothionin A-II was digested with trypsin and thermolysin to isolate cystine peptides. These were separated and
T, Hase, H, Matsubara, H, Yoshizumi
openaire   +2 more sources

Purification of a lethal toxin produced by Shigella dysenteriae

Toxicon, 1982
A lethal toxin was purified from the culture supernatant of Shigella dysenteriae 1. The purification procedure utilized ammonium sulfate fractionation, column chromatography on DEAE-cellulose, CM-cellulose, hydroxylapatite and gel filtration on Sephadex G-200. About a 4760-fold purification was achieved, with a yield of 2.7%.
K, Okamoto, Y, Takeda, T, Miwatani
openaire   +2 more sources

Anthrax lethal toxin: a weapon of multisystem destruction

Cellular and Molecular Life Sciences, 2004
Lethal toxin (LT) is a major virulence factor secreted by anthrax bacteria. It is composed of two proteins, PA (protective antigen) and LF (lethal factor). PA transports the LF inside the cell, where LF, a zinc-dependent metalloprotease cleaves the mitogen activated protein kinase kinase (MAPKK) enzymes of the mitogen activated protein kinase (MAPK ...
A, Agrawal, B, Pulendran
openaire   +2 more sources

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