Results 311 to 320 of about 94,541 (354)

Successful Organ Donation After Yew Intoxication. [PDF]

Transpl Int
Appelt P, Stuerzebecher A, Weidhase L, Ziganshyna S.   +3 more
europepmc   +1 more source

Update on preclinical models of cancer therapy‐related cardiac dysfunction: Challenges and perspectives. A scientific statement of the Heart Failure Association (HFA) of the ESC, the ESC Council of Cardio‐Oncology, and the ESC Working Group on Cellular Biology of the Heart

European Journal of Heart Failure, EarlyView.
New anticancer therapies with potential cardiovascular side effects are continuously being introduced into clinical practice, with new and often unexpected toxicities becoming apparent only after clinical introduction. These unknown toxicities should be identified and understood beforehand to better prepare patients and physicians, enabling the ...
Alessandra Ghigo, Pietro Ameri, Aarti Asnani, Edoardo Bertero, Rudolf A. de Boer, Dimitrios Farmakis, Arantxa González, Stephane Heymans, Borja Ibáñez, Teresa López‐Fernández, Alexander R. Lyon, Piero Pollesello, Amina Rakisheva, Konstantinos Stellos, Katrin Streckfuss‐Bömeke, Carlo Gabriele Tocchetti, Thomas Thum, Peter van der Meer, Eva Van Rooij, Piotr Ponikowski, Marco Metra, Giuseppe Rosano, Sophie Van Linthout   +22 more
wiley   +1 more source

Photochemical Oxidative Cleavage and Dihydroxylation of Unsaturated Fatty Acids Using Triplet Nitroarenes

European Journal of Lipid Science and Technology, EarlyView.
Feedstock chemicals are commonly used as starting materials for specialty chemicals and their derivatization often involves oxidation reactions. Herein we report that nitroarenes can be used as photo‐responsive oxidants to achieve both the ozonolysis‐style oxidative cleavage and 1,2‐dihydroxylation of unsaturated fatty acids. The method requires simple
Piotr T. Błyszczyk, Daniele Leonori
wiley   +1 more source

Electrochemical Biosensors for Cancer Biomarker Detection: Basic Concept, Design Strategy and Cutting‐Edge Development

Electrochemical Science Advances, EarlyView.
ABSTRACT Cancer is a result of uncontrolled cell growth with the potential to damage or spread to another part of the body. It is the deadliest disease in the world; therefore, rapid and sensitive detection is essential to fight it. In the past few decades, many diagnosis tools have been developed to detect cancer and monitor therapy progress.
Md Mobarok Karim, Tahera Lasker
wiley   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Transcriptomic insights into the resistance mechanism of Penaeus vannamei against highly lethal Vibrio parahaemolyticus. [PDF]

Sci Rep
Huang Z, Liao Y, Du J, Yang Z, Li F, Ruan L, Shi H.   +6 more
europepmc   +1 more source

Identification of Potential Therapeutic Targets Against Anthrax-Toxin-Induced Liver and Heart Damage. [PDF]

Toxins (Basel)
Wu L, Chen Y, Yan Y, Wang H, Guy CD, Carney J, Moreno CL, Quintanilla-Arteaga A, Monsivais F, Zheng Z, Zeng M.   +10 more
europepmc   +1 more source

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Crystallographic studies of the anthrax lethal toxin

Journal of Applied Microbiology, 1999
Anthrax lethal toxin comprises two proteins: protective antigen (PA; MW 83 kDa) and lethal factor (LF; MW 87 kDa). We have recently determined the crystal structure of the 735-residue PA in its monomeric and heptameric forms (Petosa et al. 1997). It bears no resemblance to other bacterial toxins of known three-dimensional structure, and defines a new ...
Stephen H. Leppla, Robert J. Collier, A.D. Pannifer, Philip C. Hanna, Robert C. Liddington   +4 more
openaire   +3 more sources

Validation of the anthrax lethal toxin neutralization assay

Biologicals, 2004
A validation of the performance characteristics of a toxin neutralization assay is presented. This in vitro assay measures the functional ability of antisera, containing antibodies to anthrax lethal toxin, to specifically protect J774A.1 cells against Bacillus anthracis lethal toxin cytotoxicity.
John F. Hewetson, Donna Hering, Stephen F. Little, Judith G. Pace-Templeton, Sarah L. Norris, William Thompson   +5 more
openaire   +2 more sources

Disulfide Bonds of Purothionin, a Lethal Toxin for Yeasts

The Journal of Biochemistry, 1978
Purothionin isolated from commercial wheat flour contained several components and two of them (A-I and A-II) were isolated in pure form by CM-52 column chromatography. Each component contained 45 amino acid residues with a 4 disulfide bonds. Purothionin A-II was digested with trypsin and thermolysin to isolate cystine peptides. These were separated and
Hajime Yoshizumi, Toshiharu Hase, Hiroshi Matsubara   +2 more
openaire   +3 more sources