Results 101 to 110 of about 20,646 (210)

Increased expression of aromatase after focal cerebral ischemia: Relevance to neuroprotection and functional recovery

Neuroprotection, Volume 4, Issue 2, Page 143-156, June 2026.
Abstract Aim Aromatase is the key enzyme in the biosynthesis of 17β‐estradiol, the most potent estrogen, which has pleiotropic neuroprotective properties. Aromatase levels increase in the brain after stroke, and its gene variants increase susceptibility to stroke. This study aims to determine whether aromatase overexpression improves stroke outcome and
Lindsay Gallagher, Anna F. Dominiczak, Luis M. Garcia‐Segura, Nobuhiro Harada, J. B. Hutchison, James M. Mullin, Delyth Graham, Peter O'Shaughnessy, Hilary Victoria O. Carswell   +8 more
wiley   +1 more source

Letrozole and clomiphene versus letrozole alone for ovulation induction in women with PCOS: a systematic review and meta-analysis [PDF]

Objective: We aimed to compare the efficacy and safety of letrozole and clomiphene versus letrozole alone for ovulation induction in patients with Polycystic Ovary Syndrome (PCOS).
Karine Eskandar, Juliana Almeida Oliveira, Andrea Mora de Marco Novellino, Sandro Augusto Ribeiro, Ana Isabela de Araujo Zotti, Yasmin Jardim Meirelles Dias, Matheus Pedrotti Chavez   +6 more
core   +1 more source

Fetal Growth in Pregnancies Conceived by Single Embryo Transfer: A Prospective Observational Cohort Study During Three Trimesters

Reproductive, Female and Child Health, Volume 5, Issue 2, June 2026.
ABSTRACT Introduction The main aim is to describe fetal growth trajectories in pregnancies conceived by assisted reproductive technology (ART) from gestational week 12 until birth. The secondary aims are to compare ultrasound dating and transfer date estimations of gestational age and to describe birthweight.
Eline Bragedatter Seljeflot, Hanne Mørch, Torbjørn Moe Eggebø, Signe Opdahl, Sotirios Saravelos, Kjersti Westvik‐Johari, Birgitte Heiberg Kahrs   +6 more
wiley   +1 more source

Letrozole sensitizes breast cancer cells to ionizing radiation.

, 2005
INTRODUCTION: Radiotherapy (RT) is considered a standard treatment option after surgery for breast cancer. Letrozole, an aromatase inhibitor, is being evaluated in the adjuvant setting.
Dean B Evans, Larbouret, C., Cunat, S., Pujol, P., Evans, Dean, B., Ozsahin, Mahmut, Gilles Romieu, Mahmut Ozsahin, Pèlegrin, A., David Azria, Gourgou, S., Pujol, Pascal, Pèlegrin, André, Larbouret, Christel, Evans, Dean,, Gourgou, Sophie, Christel Larbouret, Azria, D., Pascal Pujol, Martineau, Pierre, Romieu, Gilles, Azria, David, Severine Cunat, Evans, D.B., Sophie Gourgou, Ozsahin, M., Andre Pèlegrin, Martineau, P., Pierre Martineau, Romieu, G., Cunat, Severine   +30 more
core   +1 more source

Predicting live birth following single euploid frozen‐embryo transfer via β‐hCG dynamics: iHOPE prognostic model with external validation

Ultrasound in Obstetrics &Gynecology, Volume 67, Issue 6, Page 824-835, June 2026.
ABSTRACT Objectives To determine the prognostic value of serum β‐human chorionic gonadotropin (β‐hCG) for predicting live birth following single euploid frozen‐embryo transfer (FET), and to develop and validate a prognostic model (iHOPE) for this purpose. Methods This retrospective cohort study used data from two large fertility practices.
E. Kalafat, B. Ata, R. Del Gallego, A. Freedman, L. R. Hoyos, I. Elkhatib, K. A. Miller, H. Fatemi, B. Lawrenz   +8 more
wiley   +1 more source

Letrozole removal resulted in resumption of estrous cycling.

, 2019
Estrous cycling was evaluated in placebo and letrozole-treated female mice via vaginal cytology. Vaginal smears were collected during weeks 4–5 (Pre; n = 6 placebo, n = 10 letrozole) and during weeks 10–11 (Post; n = 6 placebo, n = 8 letrozole ...
Bryan S. Ho (7444598), Lillian Sau (6468299), Scott T. Kelley (7444601), Varykina G. Thackray (7444604), Pablo Arroyo (316123)   +4 more
core   +1 more source

Loss of Brain‐Derived Estrogen Is Associated With Sex‐ and Age‐Dependent Alterations in Memory, Affective Behavior, and Hippocampal Extracellular Matrix Gene Expression

Aging Cell, Volume 25, Issue 6, June 2026.
Age, sex, and estrogen loss are widely recognized risk factors for Alzheimer's disease. Here, we show that brain‐specific aromatase knockout (bArKO) and the resulting estrogen loss lead to memory impairment, reduced social interaction, and extracellular environment dysregulation selectively in aged female mice, but not in young female or male mice ...
Natalie C. Piehl, Ariel W. Halle, Guadalupe Rodriguez, Andrea Locci, Stacy Kujawa, Caroline Haywood, John Coon V, Ross P. McNally, Zaina A. Karim, Tianming You, Hongxin Dong, Serdar E. Bulun, Hong Zhao   +12 more
wiley   +1 more source

Efficacy of clomiphene citrate and letrozole in intrauterine insemination cycles

, 2022
Background: There are two commonly used drugs for ovulation induction, Letrozole and Clomiphene Citrate (CC). Aim of the present study was to evaluate the efficacy of Letrozole and CC in women undergoing Intrauterine insemination (IUI) and also to ...
Neha Tiwari, Prasanna Kumar Shetty K, Sanketh Sathya Dhumal, Sharon Deepthi Rasquinha   +3 more
core  

Preparation of UiO-66 loaded Letrozole nano-drug delivery system: enhanced anticancer and apoptosis activity

AMB Express
The use of drug delivery systems in targeting and achieving the targeting of drugs in treating diseases, especially cancer, has attracted the attention of researchers. Letrozole is one of the drugs for the treatment of breast cancer.
Maryam Ronaghi, Ramtin Hajibeygi, Reza Ghodsi, Akram Eidi, Ronak Bakhtiari   +4 more
doaj   +1 more source

Immune Cell Composition and Prognosis in Node‐Positive, Irradiated Breast Cancer Patients in the DBCG‐IMN2 Study

APMIS, Volume 134, Issue 6, June 2026.
ABSTRACT High levels of tumor‐infiltrating lymphocytes (TILs) are associated with improved survival after radiotherapy in breast cancer (BC) patients, particularly in estrogen receptor (ER)‐negative disease. This study investigated the prognostic relevance of immune cell subsets in irradiated patients.
Demet Özcan, Anders Winther Mølby Nielsen, Patricia Switten Nielsen, Jan Alsner, Lise Bech Jellesmark Thorsen, Jens Overgaard, Birgitte Vrou Offersen, Trine Tramm   +7 more
wiley   +1 more source