Results 111 to 120 of about 31,435 (210)

Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders

Andrology, Volume 14, Issue 4, Page 1002-1016, May 2026.
Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret, Aaran H. Patel, Elisabeth Daniels, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

SPE–UPLC–MS/MS assay for determination of letrozole in human plasma and its application to bioequivalence study in healthy postmenopausal Indian women

Journal of Pharmaceutical Analysis, 2016
A rapid and sensitive ultra performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method is described for determination of letrozole in human plasma. Following solid phase extraction (SPE) of letrozole and letrozole-d4 on Orochem DVB-LP
Pravin G. Vanol, Puran Singhal, Priyanka A. Shah, Jaivik V. Shah, Pranav S. Shrivastav, Mallika Sanyal   +5 more
doaj   +1 more source

Systemic Therapy in Endometrial Cancer: Recent Advances. [PDF]

, 2013
Endometrial cancer is a chemosensitive disease. Studies have established a clear benefit of chemotherapy in advanced stages and trials are ongoing to define its role in early stages as well.
Bhise, R, Guru Prasad B, B, Kundargi, R, Lakshmaia, KC, Purohit, S, Shetty, R   +5 more
core   +1 more source

Preparation of UiO-66 loaded Letrozole nano-drug delivery system: enhanced anticancer and apoptosis activity

AMB Express
The use of drug delivery systems in targeting and achieving the targeting of drugs in treating diseases, especially cancer, has attracted the attention of researchers. Letrozole is one of the drugs for the treatment of breast cancer.
Maryam Ronaghi, Ramtin Hajibeygi, Reza Ghodsi, Akram Eidi, Ronak Bakhtiari   +4 more
doaj   +1 more source

Letrozole induced Necrotizing Cutaneous Vasculitis: A Rare Entity

Clinical Dermatology Review
Cutaneous small vessel vasculitis (CSVV) could be due to varied etiologies of which drug induced CSVV is a prime cause. It commonly presents as purpura but necrotizing lesions can be an uncommon presentation of the disease.
Liza Mohapatra, Soumya Surath Panda, Manoj Kumar Nayak, Kallolinee Samal   +3 more
doaj   +1 more source

Individualisation of the Dose of Letrozole for Ovulation Induction in Infertile Women with Polycystic Ovary Syndrome Based on Clinical and Ultrasonography Criteria: A Cohort Study

Journal of Human Reproductive Sciences
Background: Conventionally, letrozole for ovulation induction (OI) in polycystic ovary syndrome (PCOS) is started at a dose of 2.5 mg, which is gradually escalated depending on the follicular response.
Pratyasha Peepal, Padmalaya Thakur, Anubhuti Patel, Jyotiranjan Sahoo, Sujata Pradhan, Manisha Sahu   +5 more
doaj   +1 more source

Effects of letrozole, non-steroidal aromatase inhibitor, on serum sex steroid levels, oocyte diameter and gonadosomatic index (GSI) in rainbow trout (Oncorhynchus mykiss) [PDF]

, 2015
The objective of this study was to contribute to investigate the efficacy of letrozole, a potent non-steroidal aromatase inhibitor, on serum sex steroid levels and oocyte growth in rainbow trout females.
Akbary, P., Akhlaghi, M., Majazi Amiri, B., Mirvaghefi, A.   +3 more
core  

Bone fractures among postmenopausal patients with endocrine-responsive early breast cancer treated with 5 years of letrozole or tamoxifen in the BIG 1-98 trial [PDF]

, 2017
Background: To compare the incidence and timing of bone fractures in postmenopausal women treated with 5 years of adjuvant tamoxifen or letrozole for endocrine-responsive early breast cancer in the Breast International Group (BIG) 1-98 trial. Methods: We
Campone, M., Castiglione-Gertsch, M., Coates, A. S., Colleoni, M., Forbes, J. F., Gelber, R. D., Goldhirsch, A., Hawle, H., Láng, I., Mouridsen, H., Nogaret, J.-M, Paridaens, R. J., Pienkowski, T., Price, K. N., Rabaglio, M., Smith, I., Sun, Z., Thürlimann, B.   +17 more
core  

Comparing Ovulation Outcomes of Letrozole-Tamoxifen-Estradiolwith and without Vitamin E in Infertile Women with PolycysticOvary Syndrome: A Double-Blind, Randomized Clinical Trial. [PDF]

Int J Fertil Steril
Rasekh Jahromi A, Sharifi N, Karimi Javad M, Rahmanian V.   +3 more
europepmc   +1 more source