Results 91 to 100 of about 6,250 (152)

Letrozole co-treatment in an antagonist protocol for overweight women undergoing IVF treatment: a retrospective study

BMC Pregnancy and Childbirth
Background Overweight women undergoing IVF treatment have lower success rates. Letrozole, an aromatase inhibitor, has been used as an adjunct for IVF treatment, but its specific effects in overweight women have not been investigated.
Jing Lin, Fenglu Wu, Yanwen Zhu, Bian Wang, Zhengjun Cao, Jiaying Lin   +5 more
doaj   +1 more source

Volumetric Microsampling for Patient‐Centric Therapeutic Drug Monitoring in Clinical Pharmacology: A Scoping Review

The Journal of Clinical Pharmacology, Volume 66, Issue 9, September 2026.
Abstract Accurate drug concentration measurement is essential for precision pharmacotherapy, but conventional therapeutic drug monitoring (TDM) requires venous sampling, increasing patient burden, and potentially limiting participation in TDM and model‐informed precision dosing (MIPD).
Hari Prabhath Tummala, Abbie D. Leino, Nathaniel J. Rhodes, Kevin J. Downes, Marc H. Scheetz, Manjunath P. Pai   +5 more
wiley   +1 more source

Therapeutic Potential of Chickpea‐Derived Bioactives: A Review With Perspective of Different In Vitro, Animal, and Human Studies

Legume Science, Volume 8, Issue 3, September 2026.
ABSTRACT Chickpea (Cicer arietinum L.) is an important dietary legume worldwide and provides micronutrients and phytochemicals, including phenolics, flavonoids, carotenoids, bioactive peptides, dietary fiber, and resistant starch. This narrative review summarizes evidence from in vitro, animal, and human studies on the potential health relevance of ...
Rohama Shahid, Maria Maqsood, Nimrah Ashraf, Farzeen Asghar, Nauman Khalid   +4 more
wiley   +1 more source

Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer.

, 2009
International audiencePURPOSE: Cross-talk between human epidermal growth factor receptors and hormone receptor pathways may cause endocrine resistance in breast cancer. This trial evaluated the effect of adding lapatinib, a dual tyrosine kinase inhibitor
Mark Pegram, Steven Stein, Pippen, John, Cristina Oliva, Press, Michael, F., Gilles Romieu, Alexey Manikhas, Lisa O'Rourke, Pivot, Xavier, B., Veronique Dieras, Stein, Steven, Pegram, Mark, Dieras, Veronique, O'Rourke, Lisa, Maltzman, Julie, John Pippen, Xavier Pivot, Allison Florance, Romieu, Gilles, Oliva, Cristina, M. John Kennedy, Kennedy, M John, Sadeghi, Saeed, Florance, Allison, Manikhas, Alexey, Henry Leonidas Gomez, Saeed Sadeghi, Stephen Johnston, Johnston, Stephen, Lichinitser, Mikhail, Gomez, Henry Leonidas, Mikhail Lichinitser, Julie Maltzman, Michael F. Press   +33 more
core   +1 more source

Metabolism in Tumor: Mechanisms and Therapeutic Perspectives

MedComm, Volume 7, Issue 9, September 2026.
Tumor metabolic reprogramming converges on three hubs—the SREBP1/2–FASN–SCD1 lipogenic axis, the HIF‐1α–GLUT1–LDHA glycolytic axis, and the LDLR–SCARB1–LXR cholesterol system—which integrate transcriptional, epigenetic (histone lactylation, m6A), and microenvironmental inputs to generate metabolic plasticity, immune evasion, and therapy resistance ...
Jia‐Chen Cheng, Yi‐Xuan Hu, Xiang‐Chun Huang, Shan Jiang, Jie‐Lin Wang, Yang Zhao, Shuo Chen   +6 more
wiley   +1 more source

The Efficacy of Letrozole Co-Treatment in an Antagonist Protocol for Women with Polycystic Ovary Syndrome Undergoing IVF: A Retrospective Study [PDF]

Jing Lin,1 Fenglu Wu,2 Yanwen Zhu,2 Qianqian Zhu,2 Tong Du,2 Jiaying Lin2 1Center for Reproductive Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Department of Assisted Reproduction ...
Zhu Y, Du T, Lin J, Wu F, Zhu Q
core  

Design, Synthesis, and Investigation of the Biological Activities of New Thiadiazole Derivatives With Anticancer Effects

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
In silico studies reveal that compound 3c interacts strongly with the active site of the aromatase enzyme. In addition, compound 3c yielded promising results in in vitro enzyme inhibition and cytotoxicity studies. ABSTRACT Breast cancer is one of the most significant diseases in today's world.
Yusuf Özkay, Enes Bal, Berkant Kurban, Derya Osmaniye, Begüm Nurpelin Sağlık Özkan, Zafer Asım Kaplancıklı   +5 more
wiley   +1 more source

Investigation of Teratogenic Effects of Letrozole on Fetal Bone Development

, 2022
Letrozole is mainly used for the treatment of unexplained infertility, breast cancer and polycystic ovarian syndrome, with secondary use in ovarian stimulation.
Ertekin, Ayse, Bozkurt, Erhan, Firat, Fatma, Bilir, Abdulkadir, Atay, Emre   +4 more
core  

Synthesis, Structural Characterization, and Investigation of Biological Effects of Novel Benzothiazole‐Triazole Derivatives Designed as AKT Kinase Inhibitors

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
Novel benzothiazole‐triazole derivatives were designed and synthesized as potential anticancer agents targeting the PI3K/Akt pathway. Compound 5h exhibited potent Akt1 inhibition, induced apoptosis and mitochondrial dysfunction in MCF‐7 cells, and demonstrated stable binding in molecular docking and dynamics studies, highlighting its promise for breast
Bilge Çiftçi, Zeynep Gülenç, Büşra Korkut Çelikateş, Derya Osmaniye   +3 more
wiley   +1 more source

Letrozole: A Steroid-Free Estrous Synchronization Method [PDF]

, 2018
Most bovine estrous synchronization protocols utilize progesterone plus estrogen to control ovulation timing. A drug that inhibits estrogen production (Letrozole) may be an alternative, steroid-free synchronization method (not yet commercially available).
Kurz, Scott G., Davis, John S., Wood, Jennifer R., Cupp, Andrea S., Romereim, Sarah M., Abedal-Majed, Mohamed A., Majed, Bergman, Jeffrey W., Tenley, Sarah C.   +7 more
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