Results 91 to 100 of about 20,646 (210)

Letrozole co-treatment in an antagonist protocol for overweight women undergoing IVF treatment: a retrospective study

BMC Pregnancy and Childbirth
Background Overweight women undergoing IVF treatment have lower success rates. Letrozole, an aromatase inhibitor, has been used as an adjunct for IVF treatment, but its specific effects in overweight women have not been investigated.
Jing Lin, Fenglu Wu, Yanwen Zhu, Bian Wang, Zhengjun Cao, Jiaying Lin   +5 more
doaj   +1 more source

Pembrolizumab‐Induced Myositis: Diagnostic and Therapeutic Challenges From Two Case Reports and a Narrative Review

Cancer Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background Pembrolizumab, an anti‐PD‐1 immune checkpoint inhibitor, has transformed the treatment of multiple solid tumors. However, it can rarely cause immune‐related myositis, which may involve limb, bulbar, and respiratory muscles, posing a risk of severe morbidity and mortality. Early recognition and management are essential. We report two
Francesca Rifaldi, Niccolò Leandro Alessio, Francesca Caspani, Elena Bolzacchini, Monica Giordano, Paolo Pedrazzoli   +5 more
wiley   +1 more source

Pharmacokinetic Drug–Drug Interaction Potential of Oral Anticancer Drugs

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1614-1627, June 2026.
Drug–drug interaction (DDI) management is critical for safe and effective use of oral anticancer drugs (OADs). Our study objectives were to (i) compile clinically relevant pharmacokinetic (PK) DDI mechanisms for OADs and (ii) assess the prevalence of PK potential DDIs (PDDIs) in patients with advanced solid cancers.
Fatimah Alhurayri, Islam R. Younis, Shadia I. Jalal, Theodore F. Logan, Rohan Maniar, Steven M. Bray, Sara K. Quinney, Zeruesenay Desta, Todd C. Skaar, James E. Tisdale, Tyler Shugg   +10 more
wiley   +1 more source

Effects of Total Flavonoids From Rubus chingii Hu on the Hypothalamic–Pituitary–Ovarian Axis and Inflammatory Response in Polycystic Ovary Syndrome Rats

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
RHF improves sex hormone secretion imbalance, restores the estrous cycle, inhibits ovarian hyperplasia and pathology, and reduces systemic and local ovarian inflammation in PCOS rats via enhancing HPO axis function and suppressing NLRP3 inflammasome signaling pathway activation.
Mengfan Peng, Baosong Liu, Lanyue Cao, Chuan Rao, Yingying Sun, Caixia Li, Hao Chen, Lei Yang   +7 more
wiley   +1 more source

Ribociclib with letrozole vs letrozole alone in elderly patients with hormone receptor-positive, HER2-negative breast cancer in the randomized MONALEESA-2 trial

, 2017
Determine the efficacy and safety of first-line ribociclib plus letrozole in elderly patients with HR+, HER2- advanced breast cancer. 668 postmenopausal women with HR+, HER2- advanced breast cancer and no prior systemic therapy for advanced disease were ...
Bachelot, Thomas, Hart, Lowell L, Alba, Emilio, Favret, Anne M, Erdkamp, Frans, Germa, Caroline, Anne M. Favret, Souami, Farida, Michelle Miller, Santosh Sutradhar, Erik Wist, Wist, Erik, Miller, Michelle, Emilio Alba, Sonke, Gabe S, Gabe S. Sonke, Sutradhar, Santosh, Mario Campone, Frans Erdkamp, Lowell L. Hart, Caroline Germa, Hegg, Roberto, Jakobsen, Erik, Burris, Howard A, Paul Wheatley-Price, Verma, Sunil, Roberto Hegg, Sunil Verma, Erik Jakobsen, Wheatley-Price, Paul, Wolfgang Janni, Thomas Bachelot, Janni, Wolfgang, Farida Souami, Howard A. Burris, Campone, Mario, Cristian Villanueva, Villanueva, Cristian   +37 more
core   +1 more source

Acupuncture Versus Clomiphene for Ovulation Induction in Women With Polycystic Ovary Syndrome (PCOS): A Randomized Clinical Trial

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims There is evidence of the beneficial effects of acupuncture in the treatment of polycystic ovary syndrome (PCOS). This study aimed to compare acupuncture with clomiphene in ovulation induction among infertile women with PCOS.
Leili Hafizi, Hamideh Azizi, Malihe Mahmoudinia, Mona Jafari, Hamidreza Bahrami Taghanaki, Habibollah Esmaili, Shiva Golmohammadzadeh, Hoda Azizi   +7 more
wiley   +1 more source

Letrozole plus metformin versus letrozole alone in the treatment of symptomatic endometrioma

Background: Endometriosis is a chronic, estrogen-dependent inflammatory disorder affecting up to 10% of reproductive-age women, with endometrioma present in 17-44% of cases and linked to pain and subfertility.
Salam, Sharmin, Anwary, Shaheen Ara, Rolly, Suraiya Jahan, Tarique, Mostafa M. Al, Banu, Jesmine, Mahmud, Shihan, Rani, Reeta, Saha, Chandana, Sultana, Rebeka   +8 more
core   +1 more source

SPE–UPLC–MS/MS assay for determination of letrozole in human plasma and its application to bioequivalence study in healthy postmenopausal Indian women

Journal of Pharmaceutical Analysis, 2016
A rapid and sensitive ultra performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method is described for determination of letrozole in human plasma. Following solid phase extraction (SPE) of letrozole and letrozole-d4 on Orochem DVB-LP
Pravin G. Vanol, Puran Singhal, Priyanka A. Shah, Jaivik V. Shah, Pranav S. Shrivastav, Mallika Sanyal   +5 more
doaj   +1 more source

Multidisciplinary Strategies for Targeting Tumor Dormancy in Breast Cancer Therapeutics: Hallmarks, Mechanism, and Approaches

iMetaMed, Volume 2, Issue 2, June 2026.
Clinical phases and classification of breast tumor dormancy. Tumor dormancy is described as the period after treatment until residual tumor cells become detectable as relapsing disease in clinic. During the period of clinical tumor dormancy, tumor mass dormancy and cellular dormancy may coexist.
Shu Chen, Hui Chen, Vijaya Raghavan, Jing Huang, Jin Wang   +4 more
wiley   +1 more source

The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao, Yuheng Qin, Haoyu Wan, Guang Lu, Han‐Ming Shen   +4 more
wiley   +1 more source