Results 71 to 80 of about 6,250 (152)

A comparison of letrozole and anastrozole followed by letrozole in breast cancer patients

, 2015
Potchavit Aphinives, Damnern Vachirodom, Chaiyut Thanapaisal, Dhanes Rangsrikajee, Ongart SomintaraDepartment of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandBackground: We previously studied the noninferiority of anastrozole ...
Thanapaisal C, Rangsrikajee D, Somintara O, Vachirodom D, Aphinives P   +4 more
core  

Critical Windows of Air Pollution Exposure During Spermatogenesis and Intrauterine Insemination Outcomes

Paediatric and Perinatal Epidemiology, EarlyView.
ABSTRACT Background Male preconception health remains a critically under‐addressed area of family planning. While research suggests air pollution may harm semen quality, downstream impacts on pregnancy, particularly for more vulnerable infertility treatment populations, are understudied.
Lindsey M. Russo, J. Richard Pilsner, Timothy P. Canty, Neil J. Perkins, Pauline Mendola, Karen C. Schliep, May Shaaban, Rachael B. Hemmert, Akanksha Singh, Allison M. Ring, James A. Vanderslice, C. Matthew Peterson, Erica B. Johnstone, Kaniz Rabeya, Carrie Nobles   +14 more
wiley   +1 more source

Ovulation rates in a stair-step protocol with Letrozole vs clomiphene citrate in patients with polycystic ovarian syndrome

Contraception and Reproductive Medicine, 2019
Purpose To compare ovulation rates between Letrozole and Clomiphene Citrate (CC) using a stair-step protocol to achieve ovulation induction in women with Polycystic Ovarian Syndrome (PCOS). Methods This is a retrospective cohort of predominantly Hispanic
S. Thomas, I. Woo, J. Ho, T. Jones, R. Paulson, K. Chung, K. Bendikson   +6 more
doaj   +1 more source

GP88 (PC-Cell Derived Growth Factor, progranulin) stimulates proliferation and confers letrozole resistance to aromatase overexpressing breast cancer cells

BMC Cancer, 2011
Background Aromatase inhibitors (AI) that inhibit breast cancer cell growth by blocking estrogen synthesis have become the treatment of choice for post-menopausal women with estrogen receptor positive (ER+) breast cancer.
Sabnis Gauri, Brodie Angela, Abrhale Tesfom, Macedo Luciana, Tian Changsheng, Yue Binbin, Serrero Ginette   +6 more
doaj   +1 more source

Efficacy and Safety of Controlled Ovarian Stimulation With or Without Letrozole Co-administration for Fertility Preservation: A Systematic Review and Meta-Analysis

Frontiers in Oncology, 2020
Background: The co-administration of letrozole during controlled ovarian stimulation (COS) with gonadotropins is used to limit the potentially harmful effects of a supra-physiological rise in estrogen levels on hormone-sensitive cancers.
Benedetta Bonardi, Benedetta Bonardi, Claudia Massarotti, Marco Bruzzone, Oranite Goldrat, Giorgia Mangili, Paola Anserini, Stefano Spinaci, Luca Arecco, Luca Arecco, Lucia Del Mastro, Lucia Del Mastro, Marcello Ceppi, Isabelle Demeestere, Isabelle Demeestere, Matteo Lambertini, Matteo Lambertini   +16 more
doaj   +1 more source

Exploring lifestyle management in polycystic ovary syndrome through implementation frameworks

Experimental Physiology, EarlyView.
Abstract Polyendocrine metabolic ovarian syndrome [PMOS; previously known as polycystic ovary syndrome (PCOS)] is an endocrine condition affecting 10%–13% of women of reproductive age, with cardiometabolic, reproductive and psychological features. The PMOS guidelines have established recommendations for its management, which can include pharmacological,
Margaret McGowan, Stephanie Cowan, Chau Thien Tay, Lisa J. Moran, Ashley H. Ng   +4 more
wiley   +1 more source

Antitumor activity of Z-endoxifen in aromatase inhibitor-sensitive and aromatase inhibitor-resistant estrogen receptor-positive breast cancer

Breast Cancer Research, 2020
Background The tamoxifen metabolite, Z-endoxifen, demonstrated promising antitumor activity in endocrine-resistant estrogen receptor-positive (ER+) breast cancer.
Swaathi Jayaraman, Xiaonan Hou, Mary J. Kuffel, Vera J. Suman, Tanya L. Hoskin, Kathryn E. Reinicke, David G. Monroe, Krishna R. Kalari, Xiaojia Tang, Megan A. Zeldenrust, Jingfei Cheng, Elizabeth S. Bruinsma, Sarah A. Buhrow, Renee M. McGovern, Stephanie L. Safgren, Chad A. Walden, Jodi M. Carter, Joel M. Reid, James N. Ingle, Matthew M. Ames, John R. Hawse, Matthew P. Goetz   +21 more
doaj   +1 more source

De‐Escalation of Neoadjuvant Treatment for HER2‐Positive Breast Cancer

International Journal of Cancer, Volume 159, Issue 10, Page 2393-2402, 15 November 2026.
ABSTRACT With improved prognosis in early HER2‐positive breast cancer, safely de‐escalating treatment is increasingly investigated to minimize overtreatment. This article focuses on neoadjuvant de‐escalation strategies for HER2‐positive breast cancer.
Yiyin Ma, Dedian Chen, Sheng Huang
wiley   +1 more source

Letrozole Potentiates Mitochondrial and Dendritic Spine Impairments Induced by β Amyloid

Journal of Aging Research, 2013
Reduced estrogens, either through aging or postsurgery breast cancer treatment with the oral nonsteroidal aromatase inhibitor letrozole, are linked with declined cognitive abilities.
P. K.-Y. Chang, S. Boridy, R. A. McKinney, D. Maysinger   +3 more
doaj   +1 more source

Letrozole plus metformin versus letrozole alone in the treatment of symptomatic endometrioma [PDF]

Background: Endometriosis is a chronic, estrogen-dependent inflammatory disorder affecting up to 10% of reproductive-age women, with endometrioma present in 17-44% of cases and linked to pain and subfertility.
Salam, Sharmin, Anwary, Shaheen Ara, Rolly, Suraiya Jahan, Tarique, Mostafa M. Al, Banu, Jesmine, Mahmud, Shihan, Rani, Reeta, Saha, Chandana, Sultana, Rebeka   +8 more
core   +1 more source