Results 61 to 70 of about 22,913 (185)

Randomized phase II trial of letrozole and letrozole plus low-dose metronomic oral cyclophosphamide as primary systemic treatment in elderly breast cancer patients [PDF]

, 2006
PURPOSE: To investigate the activity of letrozole plus/minus oral metronomic cyclophosphamide as primary systemic treatment (PST) in elderly breast cancer patients.
Claudio Bernardi, Dionisio, Rossana, Alberto Bottini, Alfredo Berruti, Bersiga, Alessandra, Berruti, Alfredo, Allevi, Giovanni, GENERALI, DANIELE, Sergio Aguggini, Bonardi, Simone, Bernardi, Claudio, Stephen B. Fox, Alessandra Bersiga, Aguggini, Sergio, Dogliotti, Luigi, Giuliana Bodini, Bodini, Giuliana, Arianna Montruccoli, Fox, Stephen B., Brizzi, Maria Pia, Bruzzi, Paolo, Manuela Milani, Rossana Dionisio, Paolo Bruzzi, Simone Bonardi, Bottini, Alberto, Maria Pia Brizzi, Giovanni Allevi, Adrian L. Harris, Daniele Generali, Luigi Dogliotti, Harris, Adrian L., Milani, Manuela, Montruccoli, Arianna   +33 more
core   +2 more sources

Pregnancy And Neonatal Outcomes Of hMG Stimulation With Or Without Letrozole In Endometrial Preparation For Frozen–Thawed Embryo Transfer In Ovulatory Women: A Large Retrospective Cohort Study

Drug Design, Development and Therapy, 2019
Jiaying Lin,* Ningling Wang,* Jialv Huang, Renfei Cai, Yong Fan, Yanping Kuang, Yun Wang Department of Assisted Reproduction, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ...
Lin J, Wang N, Huang J, Cai R, Fan Y, Kuang Y, Wang Y   +6 more
doaj  

Off-label letrozole for tubal pregnancy monotherapy is not an alternative to methotrexate: a prospective cohort study

Ginekologia Polska
OBJECTIVES: Inhibition of estradiol production by letrozole may interfere with physiological effects of progesterone necessary to maintain the pregnancy.
Iwona M. Gawron, Dorota Babczyk, Robert Jach   +2 more
doaj   +1 more source

Endocrine therapy‐induced cancer‐related fatigue in hormone‐dependent malignancies: Mechanisms, impact, and management strategies

Precision Medical Sciences, EarlyView.
Multipathway schematic of endocrine therapy–induced cancer‐related fatigue. Endocrine interventions trigger four interacting mechanisms—neuroendocrine dysregulation, systemic inflammation, energy‐metabolic failure, and psycho‐behavioral amplification—that culminate in the multidimensional CRF phenotype.
Jiajing Jiang, Jun Lu, Sen Qin, Ruzhou Chen, Qiuchen Zhang, Lvqi He, Yubei Li, Jingyao Yan   +7 more
wiley   +1 more source

Letrozole removal resulted in resumption of estrous cycling.

, 2019
Estrous cycling was evaluated in placebo and letrozole-treated female mice via vaginal cytology. Vaginal smears were collected during weeks 4–5 (Pre; n = 6 placebo, n = 10 letrozole) and during weeks 10–11 (Post; n = 6 placebo, n = 8 letrozole ...
Bryan S. Ho (7444598), Lillian Sau (6468299), Scott T. Kelley (7444601), Varykina G. Thackray (7444604), Pablo Arroyo (316123)   +4 more
core   +1 more source

Palbociclib in the Treatment of HR+/ HER2‐ Advanced or Metastatic Breast Cancer in Australia: A Real‐World Retrospective Analysis

Asia-Pacific Journal of Clinical Oncology, EarlyView.
This study investigated the real‐world use of CDK4/6 inhibitors in Australian patients with HR+/HER2‐ advanced or metastatic breast cancer, providing data on patient demographics, treatment patterns, and outcomes with palbociclib. ABSTRACT Background There is limited real‐world data on the use of CDK4/6 inhibitors in Australian patients with HR+/HER2 ...
Louise Nott, Eugene Moylan, Maree Colosimo, Giles Stratton, Thomas Chiu, Mahsa H. Kouhkamari, Maureen Hitschfeld, Jessica Michie, Richard De Boer   +8 more
wiley   +1 more source

Systemic Therapy Management Strategies for Early‐Stage Breast Cancer in Australia

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Advances in systemic therapy for early‐stage breast cancer in Australia highlight genomic‐guided decisions, subtype‐specific strategies, and emerging targeted and immunotherapies, shaping personalized and de‐escalated treatment approaches. ABSTRACT Breast cancer is the most common cancer among Australian women, with early‐stage disease (Stages I, II ...
Nicholas Zdenkowski, Rachel Dear, Sanjeev Kumar, Hilary Martin, Dhanusha Sabanathan, Stephen J. Luen, Belinda Yeo   +6 more
wiley   +1 more source

CDK4/6 Inhibitors in the Management of Hormone Receptor‐Positive (HR+)/Human Epidermal Growth Factor Receptor 2‐Negative (HER2−) Advanced Breast Cancer in Indonesia: Challenges, Opportunities, and Recommendations

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Evidence‐informed recommendations emphasize the integration of CDK4/6 inhibitors with endocrine therapy as a central component in the management of HR+/HER2− advanced breast cancer in Indonesia. Expanding access and facilitating integration within national treatment frameworks are crucial to improve outcomes and reduce disparities in care.
Sonar Soni Panigoro, Samuel J. Haryono, Prihantono Prihantono, Dedy Hermansyah, Sumadi Lukman Anwar, Yohana Azhar, Febriyanto Kurniawan, Putu Anda Tusta Adiputra, Kristanto Yuli Yarso, Asdi Wihandono   +9 more
wiley   +1 more source

Pregnancy Outcomes of Intrauterine Insemination Using Microfluidics ZyMot Device for Patients With High Sperm DNA Fragmentation: An Exploratory Retrospective Study

Andrology, EarlyView.
ABSTRACT Background High sperm DNA fragmentation affects male fertility and negatively correlates with sperm survival and pregnancy rates. The use of microfluidic devices allows more rigorous sperm selection, avoiding the centrifugation which is detrimental to DNA integrity.
O. Kesidou, H. Hamze, R. Hemmings, S. Phillips   +3 more
wiley   +1 more source

CDK4/6 Inhibitors and Curcumin Synergistically Suppress HER2− Breast Cancer via Lethal ROS and Inhibition of Metastasis

Cancer Science, EarlyView.
Schematic illustrating that CDK4/6 inhibitors combined with curcumin induce lethal ROS accumulation by disrupting redox balance, downregulating GPX4, and depleting glutathione, leading to DNA damage and lipid peroxidation. This oxidative stress triggers tumor cell death and suppresses EMT‐driven migration.
Chenyu Wang, Yiqin Zou, Chunyu Chang, Siyue Liu, Xiankun Ke, Liang Hu, Di Wang, Yukang Lu, Shiwen Luo, Sijian Huang, Yilan Hu, Wenqi Yu, Aiping Deng, Ming Yue, Jue Jiang   +14 more
wiley   +1 more source