Results 171 to 180 of about 285,613 (247)

Crown Ether–Peptide Rotaxanes

Angewandte Chemie, EarlyView.
The synthesis of crown ether‐peptide rotaxanes is reported, incorporating a broad range of canonical and unnatural peptides into a threaded peptide backbone without the need for additional nonamide template sites in the axle. The 24C8 macrocycle is locked on the glycine residue used to assemble the rotaxane, allowing the formation of different ...
Peng‐Lai Wang, Peng Chen, Raorao Yang, Daniel J. Tetlow, Zhi‐Hui Zhang, Jing Han, Stephen D. P. Fielden, Prodip Howlader, Liang Zhang, David A. Leigh   +9 more
wiley   +2 more sources

Disturbances in amino acid metabolism in obstructive sleep apnea-hypopnea syndrome: insights from a cross-sectional study. [PDF]

Eur J Med Res
Huang J, Chen L, Zhong Y, Xie H, Chen M, Chen G, Lin Q.   +6 more
europepmc   +1 more source

Systematic review of the subcutaneous air pouch model using monosodium urate and calcium pyrophosphate and recommendations for studying crystal‐related arthropathies

Animal Models and Experimental Medicine, EarlyView.
Simplified schematic for generation of the subcutaneous air pouch model in the rodent. On day 0 and 4, air is injected into the subcutaneous space on the dorsal surface of the rodent to generate a cavity analogous to a synovial joint. On day 6, monosodium urate (MSU) or calcium pyrophosphate (CPP) crystals are injected into the pouch to stimulate ...
Wenu Hewage, Josif Vidimce, Ryan G. Shiels, Michael Morgan, Andrew C. Bulmer   +4 more
wiley   +1 more source

Loss-of-function coding variants in the Ras of complex proteins/GTPase domain of leucine rich repeat kinase 2. [PDF]

Protein Sci
Butterfield S, Herbst S, Lewis PA.
europepmc   +1 more source

Cerebrospinal Fluid Metabolome in Central Nervous System Infections: A Study of Diagnostic Accuracy

Annals of Neurology, EarlyView.
Objective To assess the diagnostic accuracy of metabolites in cerebrospinal fluid (CSF) for central nervous system (CNS) infections. Methods Patients were derived from three prospective cohort studies in the Netherlands. All studies included adults suspected of a CNS infection who underwent a diagnostic lumbar puncture.
Steven L. Staal, Sabine E. Olie, Michel van Weeghel, Bauke V. Schomakers, Frédéric M. Vaz, I‐PACE Study Group, Diederik van de Beek, Matthijs C. Brouwer   +7 more
wiley   +1 more source

Metabolomics reveals key biomarkers for ischemic stroke: a systematic review of emerging evidence. [PDF]

Front Neurol
Ding L, Zhang M, Fan B, Deng F, Li Z, Han Y, Wu Y, Zeng J, Lu L.   +8 more
europepmc   +1 more source

Biallelic Variants in the DARS2 Gene as a Novel Cause of Axonal Charcot–Marie–Tooth Disease

Annals of Neurology, EarlyView.
Objective Charcot–Marie–Tooth (CMT) disease is a heterogeneous group of genetic neuropathies, with >90 genes identified. Several aminoacyl‐tRNA synthetases have been linked to CMT. DARS2, encoding the mitochondrial aspartyl‐tRNA synthetase, has been typically associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate ...
Berta Estévez‐Arias, Siiri Sarv, Nathalie Bonello‐Palot, Laura Carrera‐García, Carlos Ortez, Jesica Expósito‐Escudero, Delia Yubero, Jordi Muchart, Emilien Delmont, Eve Õiglane‐Shlik, Teele Meren, Sanna Puusepp, Ülle Murumets, Gajja S. Salomons, Bjarne Udd, Liis Väli, Lara Cantarero, Carsten G. Bönnemann, Andrés Nascimento, Santiago Ramón‐Maiques, Katrin Õunap, Janet Hoenicka, Daniel Natera‐de Benito, Francesc Palau   +23 more
wiley   +1 more source

Leucine Supplementation Counteracts the Atrophic Effects of HDAC4 in Rat Skeletal Muscle Submitted to Hindlimb Immobilization. [PDF]

Muscle Nerve
Alves PKN, Cruz A, Silva WJ, Melazzo AM, Labeit S, Adams V, Moriscot AS.   +6 more
europepmc   +1 more source