Results 181 to 190 of about 639,233 (341)

Multistep metabolic engineered <i>Klebsiella oxytoca</i> for efficient l-leucine production. [PDF]

Synth Syst Biotechnol
Sun W, Yang Q, Wang S, Gong L, Zhou Z, Liu M, Tan X, Kang Q, Meng W, Liu Y, Kang Z, Xu P, Ma C, Gao C, Lü C.   +14 more
europepmc   +1 more source

Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators

Advanced Science, EarlyView.
The mammalian TGFβ interacts with ubiquitously expressed TGFBR1 and TGFBR2, and current TGFβ‐targeting agents are non‐cell‐selective. The cooperative interaction of the modular parasite TGFβ antagonist with multiple host (co‐)receptors empowers the design of TGM chimeras and bispecific antibodies that activate or inhibit TGFβ signaling in a cell ...
Maarten van Dinther, Tristin Schwartze, Jiying Zhang, Kun Fan, Gerard van der Zon, Luke Power, Cynthia S. Hinck, Claire Ciancia, Ananya Mukundan, Roman Gonzalez‐Prieto, Peter van Veelen, Rick M. Maizels, Andrew P. Hinck, Peter ten Dijke   +13 more
wiley   +1 more source

SLC7A5 regulates B cell metabolism and plasma cell differentiation independent of leucine transport. [PDF]

J Immunol
Tao AY, Hu K, Noyer L, Zhong L, Li W, Wang L, Feske S.   +6 more
europepmc   +1 more source

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

Determination of the structure and dynamics of linear polypeptide gramicidin A at atomic-scale resolution. [PDF]

RSC Adv
Laxmi Pradhan B, Sen P, Kumar A, Bhunia A, Kishor Dey K, Ghosh M.   +5 more
europepmc   +1 more source

Protein leucine content is a determinant of shorter- and longer-term muscle protein synthetic responses at rest and following resistance exercise in healthy older women: a randomized, controlled trial.

American Journal of Clinical Nutrition, 2018
M. Devries, C. McGlory, D. Bolster, Alison G Kamil, Maike Rahn, L. Harkness, S. Baker, Stuart M Phillips   +7 more
semanticscholar   +1 more source

Prognostic Value of Psoas Major Muscle Volume in Assessing Sarcopenia in Elderly Patients With Rectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
This study investigates the prognostic utility of a novel volumetric indicator—psoas volume index (PVI)—for assessing sarcopenia in elderly rectal cancer patients. Sarcopenia classified by our proposed PVI cut‐off values was associated with poor nutritional and inflammatory status, and patients with low PVI showed significantly worse long‐term outcomes.
Gen Tsujio, Shoichi Manabe, Akio Shiomi, Yusuke Tanaka, Shunsuke Kasai, Tadahiro Kojima, Takahiro Igaki, Yukihiro Mori, Akifumi Notsu   +8 more
wiley   +1 more source

Oral amino acid tracer delivery detects feeding and exercise changes in myofibrillar protein synthesis rates in male adults. [PDF]

Physiol Rep
Mazzulla M, Hodson N, Scaife PJ, Smith K, Atherton PJ, Burd NA, Kumbhare DA, Moore DR.   +7 more
europepmc   +1 more source

Physico-Chemical Properties, Aerosolization and Dissolution of Co-Spray Dried Azithromycin Particles with L-Leucine for Inhalation

Pharmaceutical Research, 2018
S. Mangal, Haichen Nie, Rongkun Xu, Rui Guo, Alex A. Cavallaro, D. Zemlyanov, Q. Zhou   +6 more
semanticscholar   +1 more source

Sex‐Based Body Composition Changes in Patients With Rectal Cancer Undergoing Preoperative Chemoradiotherapy: A Prospective Observational Study

Annals of Gastroenterological Surgery, EarlyView.
This prospective study observed that preoperative chemoradiotherapy for rectal cancer was associated with reductions in body fat and grip strength, which appeared to be more pronounced in female patients. These findings suggest that sex‐sensitive nutritional and exercise support may be beneficial to help maintain muscle mass and physical function ...
Shinya Abe, Hiroaki Nozawa, Kentaro Abe, Yumi Yokota, Shunsuke Hori, Yusuke Taguchi, Mitsutaka Yakabe, Kazuhito Sasaki, Sumito Ogawa, Soichiro Ishihara   +9 more
wiley   +1 more source