Results 181 to 190 of about 370,636 (381)

An Intracellular Peptide Library Screening Platform Identifies Irreversible Covalent Transcription Factor Inhibitors

Advanced Science, EarlyView.
A peptide library screening platform has been developed to discover covalent transcription factor inhibitors. It identifies an antagonist cysteine residue, which forms an inhibitory disulphide with cJun C269. Conversion of this cysteine to an electrophile generates an irreversible and selective cJun inhibitor, validating this approach for covalent ...
Andrew Brennan, Scott Lovell, Keith W Vance, Jody M Mason   +3 more
wiley   +1 more source

THE METABOLIC ACTIVITY OF THE α-, β-, AND γ-HYDROGEN ATOMS OF l-LEUCINE AND THE α-HYDROGEN OF GLYCINE

, 1950
David B. Sprinson, D. Rittenberg
openalex   +1 more source

Reactions Sequence of Leucine Activation Catalysed by Leucyl-RNA Synthetase. 1. Kinetic Studies [PDF]

, 1968
Pierre Rouget, F. Chapeville
openalex   +1 more source

Leucine competes with kynurenine for blood-to-brain transport and prevents lipopolysaccharide-induced depression-like behavior in mice

Molecular Psychiatry, 2018
A. Walker, E. Wing, W. Banks, R. Dantzer
semanticscholar   +1 more source

Leucine‐Rich Repeat‐Containing G Protein‐Coupled Receptor 6 Ameliorates Pressure Overload‐Induced Cardiac Hypertrophy by Regulating Cardiomyocyte Metabolic Reprogramming

Advanced Science, EarlyView.
LGR6 overexpression ameliorates cardiac hypertrophy by regulating metabolic reprogramming through USP4‐PPARα pathway. Abstract Metabolic reprogramming is a pivotal mechanism in the pathogenesis of pathological cardiac hypertrophy. Leucine‐rich repeat‐containing G protein‐coupled receptor 6 (Lgr6) has emerged as a significant player in cardiovascular ...
Mengmeng Zhao, Jianfang Liu, Shanshan Peng, Zihui Zheng, Siqi Liu, Jun Wan, Yao Xu, Menglong Wang   +7 more
wiley   +1 more source

Machine learning discoveries of ASCL2-X synergy in ETC-1922159 treated colorectal cancer cells [PDF]

arXiv
Achaete-scute complex homolog 2 (ASCL2) codes a part of the basic helix-loop-helix (BHLH) transcription factor family. WNTs have been found to directly affect the stemness of the tumor cells via regulation of ASCL2. Switching off the ASCL2 literally blocks the stemness process of the tumor cells and vice versa.
arxiv  

DiffMC‐Gen: A Dual Denoising Diffusion Model for Multi‐Conditional Molecular Generation

Advanced Science, EarlyView.
DiffMC‐Gen, a dual‐diffusion model for 2D and 3D molecular generation, simultaneously optimizes multiple key objectives across the drug design process, enabling the generation of novel, target‐specific small‐molecule ligands with high therapeutic potential.
Yuwei Yang, Shukai Gu, Bo Liu, Xiaoqing Gong, Ruiqiang Lu, Jiayue Qiu, Xiaojun Yao, Huanxiang Liu   +7 more
wiley   +1 more source

Leucine Metabolism of Streptococcus Lactis VAR. Maltigenes. II. Transaminase and Decarboxylase Activity of Acetone Powders

, 1956
Patricia MacLeod, M.E. Morgan
openalex   +1 more source

A Putative Leucine-Rich Repeat Receptor Kinase Involved in Brassinosteroid Signal Transduction

Cell, 1997
Jianming Li, J. Chory
semanticscholar   +1 more source

Explainable Deep Multilevel Attention Learning for Predicting Protein Carbonylation Sites

Advanced Science, EarlyView.
Selective carbonylation sites (SCANS) are conceptualized, designed, evaluated, and released. SCANS captures segment‐level, protein‐level, and residue embeddings features. It utilizes elaborate loss function to penalize cross‐predictions at the residue level.
Jian Zhang, Jingjing Qian, Pei Wang, Xuan Liu, Fuhao Zhang, Haiting Chai, Quan Zou   +6 more
wiley   +1 more source