Results 181 to 190 of about 603,709 (398)

The Neglected Role of GSDMD C‐Terminal in Counteracting Type I Interferon Signaling

Advanced Science, EarlyView.
The C‐terminal domain of Gasdermin D (GSDMD‐CT) shows functions beyond pyroptosis. GSDMD‐CT negatively regulates IFN‐I signaling during viral infection by triggering autophagic degradation of RIG‐I and TBK1. GSDMD‐CT interacts with retinoic acid‐inducible gene‐I (RIG‐I) and tank‐binding kinase 1 (TBK1), leading to TRIM28‐mediated ubiquitination and ...
Weilv Xu, Suhui He, Wen Shi, Jinxia Xu, Shiyang Liu, Zexu Yu, Danyue Li, Qiao Jin, Yumeng Wang, Zian Zhang, Qian Lv, Yuanxiang Ge, Yunjie Li, Xinyue Li, Nan Chen, Xinyu Fu, Yang Yang, Fushan Shi   +17 more
wiley   +1 more source

Remote Control of Eukaryotic Gene Expression by a Modular Ultrasound‐Responsive RNA Toolkit

Angewandte Chemie, EarlyView.
A modular RNA‐based sonogenetic toolkit enables remote control of gene expression in eukaryotes by releasing small molecule modulators from ultrasound‐responsive carriers. These modulators activate engineered mRNA elements such as riboswitches, leading to tunable protein expression.
Fahimeh Charbgoo, Aman Ishaqat, Junlin Chen, Fabian Wiertz, Adrian Kuzmanović, Matthias Bartneck, Fabian Kiessling, Andreas Herrmann   +7 more
wiley   +2 more sources

THE SPECIFICITY OF LEUCINE AMINOPEPTIDASE

, 1949
Emil L. Smith, W. J. Polglase
openalex   +1 more source

Anthocyanins Prevent Mastitis Exacerbation by Inhibiting PANoptosis Activation

Advanced Science, EarlyView.
PANoptosis activation is an effective therapeutic target during mastitis progression, and Gasdermin D activation is key factor contributing to blood milk barrier damage during mastitis, while cyanidin 3‐O‐galactoside can inhibit these targets to exert a protective effect. Therefore, the extraction of key active ingredients from plants for the treatment
Rui Feng, Lin Guo, Fan Wang, Qian Zhang, Guoyan Wang, Hefei Huang, Wei Du, Hong An, Yue Yang, Henghui Miao, Peng Zheng, Tingting Chu, Dengke Zhang, Xiaoxue Yan, Xiaoyu Mi, Qian Ma, Weilin Gao, Yushan Li, Song Li, Yong Zhang, Zhenliang Zhu, Yu Wang, Jun Liu, Xu Liu   +23 more
wiley   +1 more source

The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4‐Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against Malaria

Angewandte Chemie, EarlyView.
AZD0156, an ATM kinase inhibitor in clinical development, shows promising multistage antiplasmodial activity by targeting Plasmodium falciparum phosphatidylinositol 4‐kinase (PfPI4Kβ). With an improved specificity profile relative to other PfPI4Kβ inhibitors and moderate efficacy in a P.
John G. Woodland, Dina Coertzen, Kathryn J. Wicht, Virginia Franco Hidalgo, Charisse Flerida A. Pasaje, Luiz C. Godoy, Tarrick Qahash, Mmakwena M. Mmonwa, Godwin A. Dziwornu, Lynn Wambua, Sarah Harries, Constance M. Korkor, Mathew Njoroge, Liezl Krugmann, Dale Taylor, Meta Leshabane, Henrico Langeveld, Tayla Rabie, Janette Reader, Mariëtte van der Watt, Nelius Venter, Erica Erlank, Ayesha S. Aswat, Lizette L. Koekemoer, Tomas Yeo, Jin H. Jeon, David A. Fidock, Francisco Javier Gamo, Sergio Wittlin, Jacquin C. Niles, Manuel Llinas, Lauren B. Coulson, Lyn‐Marié Birkholtz, Kelly Chibale   +33 more
wiley   +2 more sources

High gestational leucine level dampens WDPCP/MAPK signaling to impair the EMT and migration of cardiac microvascular endothelial cells in congenital heart defects

Pulmonary Circulation
Congenital heart defects (CHDs) represent one of the most prevalent categories of neonatal defects, and maternal dietary patterns have been linked to the risk of these conditions.
Wei Hong, Guozhou You, Zhongming Luo, Mingxiang Zhang, Jian Chen   +4 more
doaj   +1 more source

EVIDENCE THAT INSULIN RELEASE IS THE MECHANISM FOR EXPERIMENTALLY INDUCED LEUCINE HYPOGLYCEMIA IN MAN* [PDF]

, 1963
John C. Floyd, Stefan S. Fajans, Ralph F. Knope, Jerome W. Conn   +3 more
openalex   +1 more source

Leucine competes with kynurenine for blood-to-brain transport and prevents lipopolysaccharide-induced depression-like behavior in mice

Molecular Psychiatry, 2018
A. Walker, E. Wing, W. Banks, R. Dantzer
semanticscholar   +1 more source

Cooperative Photometallobiocatalysis: Nonheme Fe Enzyme‐Catalyzed Enantioconvergent Radical Decarboxylative Azidation, Thiocyanation, and Isocyanation of Redox‐Active Esters

Angewandte Chemie, EarlyView.
Through the directed evolution of an underexploited nonheme Fe extradiol dioxygenase, we developed a unified cooperative photobiocatalytic strategy to allow for three types of enantioconvergent radical transformations, including azidation, thiocyanation, and isocyanation.
Liu‐Peng Zhao, Ken Lin, Pei‐Pei Xie, Huichong Liu, Hengye Xiang, Xin Liu, Yunlong Zhao, Peng Liu, Yang Yang   +8 more
wiley   +2 more sources

The soluble leucine pool in maize root tips. [PDF]

, 1965
Ann Oaks
openalex   +1 more source