Results 181 to 190 of about 526,044 (282)

Leucine Zipper [PDF]

, 2020
openaire   +1 more source

Aufklärung des Wirkmechanismus der Synthetase: Das Dimer der Pyrrolysyl‐tRNA‐Synthetase nutzt sekundäre Bindungsstellen in der Zelle

Angewandte Chemie, EarlyView.
Das Dimer der Pyrrolysyl‐tRNA‐Synthetase zeigt im katalytischen Zyklus einen alternierenden Wirkmodus seiner Monomere, der durch die Belegung sekundärer Bindungsstellen an den Intermonomer‐Grenzflächen außerhalb der katalytischen Bindungsstelle realisiert wird.
Jessica Dröden, Christoph Globisch, Eliane Landwehr, Theresa S. Braun, Daniel Summerer, Christine Peter, Malte Drescher   +6 more
wiley   +1 more source

Scalable Access to N‑Acylindole Linkages: Enabling the Synthesis of Antitrypanosomal Noncanonical Cyclic Peptides for Chagas Disease

Angewandte Chemie, EarlyView.
A gram‐scale supply of bulbiferamide A, which features a rare N‐acylindole linkage and possesses potent inhibitory activity against Trypanosoma cruzi epimastigotes (IC50 = 4.1 µM)—the causative parasite of Chagas disease—was successfully achieved. Moreover, the cyclization strategy developed in this study facilitated the synthesis of noncanonical ...
Jie Zhang, Hugh Nakamura
wiley   +2 more sources

The Leucine-mTOR-Autophagy Axis in Granulosa Cells Mediates Circadian Disruption-Induced Anovulation. [PDF]

Int J Biol Sci
He R, Mo J, Lin Z, Zhu K, Wang Y, Yu J, Wu H, Jiang Z, Luo Q, Liu X, Yin L, Yu C, Sheng J, Ding G, Huang H.   +14 more
europepmc   +1 more source

Urinary Amino Acid Profiling as a Non-invasive Diagnostic and Risk Stratification Tool in Prostate Cancer. [PDF]

In Vivo
Zdobinska T, Luksanova H, Duskova K, Priman O, Slavenko M, Babjuk M, Vesely S.   +6 more
europepmc   +1 more source

Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel [PDF]

, 2017
Chen, Xingyu, Cooper, Paige E., McClenaghan, Conor, Nichols, Colin G., Stary-Weinzinger, Anna   +4 more
core   +2 more sources

Shifts in nutrient allocation in a gift-giving butterfly: a hidden consequence of water balance? [PDF]

J Exp Biol
Chabaud C, Tigreros N.
europepmc   +1 more source

Effect of Disease Extent on Leucine-Rich α2-Glycoprotein as a Marker for Endoscopic Mucosal Healing in Patients With Ulcerative Colitis. [PDF]

JGH Open
Kitahata S, Saito M, Kimura Y, Nakamura A, Usui T, Kato K, Onishi K, Kanemitsu-Okada K, Kawamura T, Ohama H, Kuroda T, Matsuoka J, Tada F, Miyata H, Hiraoka A, Tsubouchi E, Ninomiya T, Hiasa Y.   +17 more
europepmc   +1 more source

Unraveling Synthetase's Mode of Action: The Pyrrolysyl‐tRNA Synthetase Dimer Uses Secondary Binding Sites in the Cell

Angewandte Chemie International Edition, EarlyView.
The pyrrolysyl‐tRNA synthetase dimer exhibits an alternating mode of action of its monomers within its catalytic cycle, which is realized upon occupation of secondary binding sites located at the intermonomer interfaces outside the catalytic binding site.
Jessica Dröden, Christoph Globisch, Eliane Landwehr, Theresa S. Braun, Daniel Summerer, Christine Peter, Malte Drescher   +6 more
wiley   +1 more source

Engineering Inhalable Carboxymethyl Chitosan-Swellable Microgels for Pulmonary Delivery of Charged Hydrophilic Molecules. [PDF]

Gels
Encinas-Basurto D, McCombs K, Vallorz EL, Acosta MF, Schnellmann RG, Mansour HM.   +5 more
europepmc   +1 more source