Results 61 to 70 of about 603,709 (398)

Impact of downstream processing on crystal quality during the precipitation of a pharmaceutical product [PDF]

, 2011
In pharmaceutical industries, active pharmaceutical ingredients (API) are made of crystals whose properties must be controlled because they influence the end-use properties of the drug.
Autret, Jean Marie, Biscans, Béatrice, Estime, Nicolas, Teychené, Sébastien   +3 more
core   +1 more source

Structural evolution drives diversification of the large LRR-RLK gene family [PDF]

, 2020
Cells are continuously exposed to chemical signals that they must discriminate between and respond to appropriately. In embryophytes, the leucine‐rich repeat receptor‐like kinases (LRR‐RLKs) are signal receptors critical in development and defense.
Arendsee Z, Dufayard J‐F, Krishnakumar V, Lanfear R, Liang Z, Monnahan PJ, R Core Team, Song W, Wilke CO   +8 more
core   +3 more sources

Protein leucine content is a determinant of shorter- and longer-term muscle protein synthetic responses at rest and following resistance exercise in healthy older women: a randomized, controlled trial.

American Journal of Clinical Nutrition, 2018
Background Older women may not be consuming enough protein to maintain muscle mass. Augmentation of protein intake with leucine may enhance the muscle protein synthetic response in older women to aid in maintaining muscle mass.
M. Devries, C. McGlory, D. Bolster, Alison G Kamil, Maike Rahn, L. Harkness, S. Baker, Stuart M Phillips   +7 more
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Genes of different catabolic pathways are coordinately regulated by Dal81 in Saccharomyces cerevisiae [PDF]

, 2015
Yeast can use a wide variety of nitrogen compounds. However, the ability to synthesize enzymes and permeases for catabolism of poor nitrogen sources is limited in the presence of a rich one.
Bermudez Moretti, Mariana, Correa Garcia, Susana Raquel, Palavecino Ruiz, Marcos Daniel   +2 more
core   +3 more sources

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Influence of Leucine on Protein Metabolism of Chicken Embryo Myoblasts is Modulated by Varying Serum Concentrations in the Medium

The Journal of Poultry Science, 2007
The influence of varying leucine and fetal calf serum (FCS) concentrations in the culture medium on protein synthesis and degradation of chicken embryo myoblasts was examined.
Mai Oki, Hiroyuki Sato, Kazuki Nakagawa, Kazumi Kita   +3 more
doaj   +1 more source

The Physiological Mechanisms of Effect of Vitamins and Amino Acids on Tendon and Muscle Healing: A Systematic Review [PDF]

, 2018
© 2018 Human Kinetics, Inc.To evaluate the current literature via systematic review to ascertain whether amino acids/vitamins provide any influence on musculotendinous healing and if so, by which physiological mechanisms.
Abuja, Abuja, Akdemir, Akdemir, Anthony, Anthony, Anthony, Anthony, Anthony, Anthony, Anthony, Anthony, Arai, Arai, Barbul, Barbul, Blass, Blass, Bonci, Bonci, Bryant, Bryant, Buettner, Buettner, Cohen, Cohen, Collins, Collins, DerSimonian, DerSimonian, DiGuiseppi, DiGuiseppi, Dinçer, Dinçer, Ehrlich, Ehrlich, Ehrlich, Ehrlich, Eijnde, Eijnde, Ejaz, Ejaz, Galeano, Galeano, Gordon, Gordon, Gottrup, Gottrup, Greenwald, Greenwald, Gumina, Gumina, Hackam, Hackam, Hahn, Hahn, Henderson, Henderson, Hespel, Hespel, Hess, Hess, Higgins, Higgins, Hobson, Hobson, Holm, Holm, Hooijmans, Hooijmans, Hung, Hung, Hunt, Hunt, Judkins, Judkins, Kannus, Kannus, Kaplan, Kaplan, Kato, Kato, Kilkenny, Kilkenny, Kimball, Kimball, Kirk, Kirk, Knapik, Knapik, Knobloch, Knobloch, Li, Li, Li, Li, Lima, Lima, Malinauskas, Malinauskas, McDaniel, McDaniel, McGonigle, McGonigle, McHugh, McHugh, Moher, Moher, Moher, Moher, Molinero, Molinero, Mouw, Mouw, Negro, Negro, Norton, Norton, Notarnicola, Notarnicola, Otranto, Otranto, Pereira, Pereira, Pereira, Pereira, Petróczi, Petróczi, Petróczi, Petróczi, Petróczi, Petróczi, Popay, Popay, Raynaud-Simon, Raynaud-Simon, Reagan-Shaw, Reagan-Shaw, Rodgers, Rodgers, Rosa, Rosa, Sallis, Sallis, Sax, Sax, Schultz, Schultz, Sena, Sena, Sharp, Sharp, Shaw, Shaw, Shukla, Shukla, Stechmiller, Stechmiller, Stromberg, Stromberg, Sugaya, Sugaya, Svanberg, Svanberg, Tack, Tack, Tarnuzzer, Tarnuzzer, Tipton, Tipton, Torres-McGehee, Torres-McGehee, Tsilidis, Tsilidis, Uzgare, Uzgare, Vieira, Vieira, Vieira, Vieira, Viera, Viera, Virmani, Virmani, Wasserstein, Wasserstein, Watson, Watson, Wicke, Wicke, Williams, Williams, Woo, Woo, Yoshizawa, Yoshizawa, Ömeroğlu, Ömeroğlu   +197 more
core   +1 more source

Leucine partially protects muscle mass and function during bed rest in middle-aged adults.

American Journal of Clinical Nutrition, 2016
BACKGROUND Physical inactivity triggers a rapid loss of muscle mass and function in older adults. Middle-aged adults show few phenotypic signs of aging yet may be more susceptible to inactivity than younger adults.
K. English, Joni A. Mettler, J. Ellison, M. M. Mamerow, Emily J. Arentson-Lantz, James M. Pattarini, R. Ploutz-Snyder, M. Sheffield-Moore, D. Paddon-Jones   +8 more
semanticscholar   +1 more source

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source