Results 61 to 70 of about 184,092 (245)
BCR-ABL1 tyrosine kinase sustained MECOM expression in chronic myeloid leukaemia [PDF]
, 2012 MECOM oncogene expression correlates with chronic myeloid leukaemia (CML) progression. Here we show that the knockdown of MECOM (E) and MECOM (ME) isoforms reduces cell division at low cell density, inhibits colony-forming cells by 34% and moderately ...
Jørgensen, Heather G. +18 more
core +1 more source
P425: ROLE OF LYSOSOMAL-ASSOCIATED GENE LAPMT4B IN LEUKEMIA
HemaSphere, 2022 J. Delgado-Martínez +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar +11 more
wiley +1 more source
t(8;13)(p12;q12) in an atypical chronic myeloid leukaemia case [PDF]
, 2007 Case report of a translocation : t(8;13)(p12;q12) in an atypical chronic myeloid leukaemia ...
Reid, AG, De Melo, VAS
core +1 more source
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
, 2018 The thesis uploaded talks about the various treatment approach for leukaemia. The first chapter focuses on the general overview of leukaemia. In subsequent chapters, a detailed approach is taken to emphasis various treatment protocols.
Longjohn, Samuel Tamunotonye
core
, 2020 The association of small lymphocytic lymphoma/chronic lymphocytic leukaemia (CLL) with different malignancies has been reported in the literature. Also the occurrence of a second haematological disease has been described, more frequently as a secondary ...
Stefano Licci
core +1 more source
A Dysregulated DNA Methylation Landscape Linked to Gene Expression in MLL-Rearranged AML
Epigenetics, 2020 Translocations of the KMT2A (MLL) gene define a biologically distinct and clinically aggressive subtype of acute myeloid leukaemia (AML), marked by a characteristic gene expression profile and few cooperating mutations.
Michael A. Koldobskiy +11 more
doaj +1 more source