Results 1 to 10 of about 11,312 (148)

Prognostic significance of Fc receptor-like 1 in patients with chronic lymphocytic leukemia, hairy cell leukemia, and various B-cell non-Hodgkin's lymphoma [PDF]

Leukemia Research Reports, 2019
Fc receptor-like 1 (FCRL1) positively regulates B-cell responses and may involve in the pathogenesis of B-cell malignancies. This study examined the expression pattern of FCRL1 in B-cell non-Hodgkin's lymphoma patients using real-time PCR and flow ...
Zahra Yousefi, Nahid Eskandari
doaj   +2 more sources

Obinutuzumab combined with bendamustine for the treatment of hairy cell leukemia variant: a case report and literature review [PDF]

Frontiers in Oncology
Hairy cell leukemia variant (HCL-v) is a rare and more aggressive subtype of B-cell leukemia. While it shares certain clinical features with classical hairy cell leukemia (HCL-c), HCL-v typically follows a more malignant course and responds poorly to ...
Junjun Bai, Yi Zhang, Yi Zhang, Kangqi Lv, Bei Zhang, Hongxia Wang, Zhixin Pei, Yingxin Zhao, Jingjing Gu, Huimin Wu, Qinglin Song   +10 more
doaj   +2 more sources

Pulmonary damage in a patient with hairy cell leukemia - infectious involvement or hematological disease activity? Case report

Biomedical Papers, 2023
Background. Hairy cell leukemia (HCL) is a rare indolent lymphoproliferative disease with an accumulation of mature B lymphocytes with fine reticular chromatin and cytoplasm with typical hairy-like cytoplasmic projections.
Dominika Ecsiova, Katerina Kamaradova, Marketa Nova, Petr Hoffmann, Petra Rozsivalova, Martin Simkovic, Pavel Zak   +6 more
doaj   +1 more source

Case report: A case of classic hairy cell leukemia with CNS involvement treated with vemurafenib

Frontiers in Oncology, 2023
Hairy cell leukemia (HCL) is a rare mature B-cell lymphoproliferative disorder and most often presents as classic hairy cell leukemia. This entity is characterized by an indolent course and the presence of the BRAF V600E mutation.
Anna E. Johnson, Athul Raj Raju, Aasems Jacob, Gerhard C. Hildebrandt   +3 more
doaj   +1 more source

Cell-binding microarray application in diagnosis of hairy cell leukemia

Онкогематология, 2015
We describe an application of a cell-binding microarray – to parallel study of morphology, tartrate-resistant acid phosphatase activity and detection of surface markers on peripheral blood lymphocytes of 90  atients with suspected hairy cell leukemia ...
A. N. Khvastunova, L. S. Al-Radi, N. M. Kapranov, O. S. Fedyanina, L. A. Gorgidze, S. A. Lugovskaya, E. V. Naumova, U. L. Dzhulakyan, A. V. Filatov, F. I. Ataullakhanov, S. A. Kuznetsova   +10 more
doaj   +3 more sources

HAIRY CELL LEUKEMIA

Medicine, 1978
Hairy cell leukemia is a chronic but steadily progressive malignancy usually of older males. Clinically, patients present with splenomegaly and/or cytopenia. The diagnosis is made by demonstration of the hairy cell in Wright's-stained peripheral blood and in bone marrow and by the characteristic histologic findings in the bone marrow biopsy and spleen ...
A, Turner, C R, Kjeldsberg
  +6 more sources

Constant activation of the RAF-MEK-ERK pathway as a diagnostic and therapeutic target in hairy cell leukemia

Haematologica, 2013
The BRAF-V600E mutation defines genetically hairy cell leukemia among B-cell leukemias and lymphomas. In solid tumors, BRAF-V600E is known to aberrantly activate the oncogenic MEK-ERK pathway, and targeted BRAF and/or MEK inhibitors have shown remarkable
Enrico Tiacci, Gianluca Schiavoni, Maria Paola Martelli, Emanuela Boveri, Roberta Pacini, Alessia Tabarrini, Silvia Zibellini, Alessia Santi, Valentina Pettirossi, Elisabetta Fortini, Stefano Ascani, Luca Arcaini, Giorgio Inghirami, Marco Paulli, Brunangelo Falini   +14 more
doaj   +1 more source

Selective influences in the expressed immunoglobulin heavy and light chain gene repertoire in hairy cell leukemia

Haematologica, 2008
Background We previously reported ongoing mutational and isotype switch events in the immunoglobulin (Ig) heavy chain (H) locus in hairy cell leukemia.
Francesco Forconi, Elisa Sozzi, Davide Rossi, Surinder S. Sahota, Teresa Amato, Donatella Raspadori, Livio Trentin, Lorenzo Leoncini, Gianluca Gaidano, Francesco Lauria   +9 more
doaj   +1 more source

Recent advances in understanding and managing hairy cell leukemia [version 1; referees: 4 approved]

F1000Research, 2018
Hairy cell leukemia is a rare B-cell malignancy that is characterized by an indolent course. It was initially described as a distinct entity in 1958. Before the establishment of modern treatment, median survival was only 4 years.
Tobias Roider, Brunangelo Falini, Sascha Dietrich   +2 more
doaj   +1 more source

Hairy cell leukemia with an aggressive outcome: A case report with a review of the literature

MGM Journal of Medical Sciences, 2023
Hairy cell leukemia (HCL), an uncommon cancer affecting B-lymphocytes primarily in the bone marrow and spleen, is identified by abnormal projections on malignant B cells, which give the illness its name.
Adwaita Mashelkarm, Shirish Khatu, Prakash Dive, S Sudhamani   +3 more
doaj   +1 more source